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New COVID booster vaccine shows promise in early trial

NCT ID NCT05541861

Completed ⭐️ VACCINE ⭐️ Sponsor: BioNTech SE Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study tested an experimental RNA-based COVID-19 booster vaccine in 383 healthy adults who had already received a COVID-19 vaccine. The goal was to find a safe dose and see how well the body's immune system responded. Researchers looked at side effects and immune markers after one or two doses.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

COVID-19 prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID-19 SARS-COV-2 INFECTION

Contacts and locations

Locations

  • Alliance for Multispecialty Research, LLC

    Tempe, Arizona, 85281, United States

  • Alliance for Multispecialty Research, LLC

    Knoxville, Tennessee, 37909, United States

  • Alliance for Multispecialty Research, LLC (Kansas)

    Kansas City, Missouri, 64114, United States

  • CTI Clinical Research Center

    Cincinnati, Ohio, 45212, United States

  • California Research Foundation

    San Diego, California, 92123, United States

  • Cenexel RCA (Research Centers of America)

    Hollywood, Florida, 33024, United States

  • Clinical Research Consulting, LLC

    Milford, Connecticut, 06460, United States

  • Clinical Trials of Texas, LLC / Flourish Research

    San Antonio, Texas, 78229, United States

  • DM Clinical Research

    Tomball, Texas, 77375, United States

  • Diablo Clinical Research, Inc.

    Walnut Creek, California, 94598, United States

  • Endeavor Clinical Trials, LLC

    San Antonio, Texas, 78229, United States

  • Finger Lakes Clinical Research

    Rochester, New York, 14618, United States

  • Great Lakes Clinical Trials LLC - Andersonville

    Chicago, Illinois, 60640, United States

  • Hoag Hospital

    Newport Beach, California, 92663, United States

  • Johnson County Clin-Trials, Inc. (JCCT)

    Lenexa, Kansas, 66219, United States

  • Research Institute of South Florida, Inc.

    Miami, Florida, 33173, United States

  • University of Kentucky Center for Clinical and Translational Science (outpatient clinic)

    Lexington, Kentucky, 40536, United States

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