One jab for two bugs: pfizer tests combo COVID-Flu vaccine

NCT ID NCT06237049

Completed ⭐️ VACCINE ⭐️ Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Pfizer trial tested whether a single injection combining an updated COVID-19 vaccine and a flu vaccine is safe and triggers a strong immune response. The study involved 644 healthy adults aged 50 and older. Researchers measured side effects and antibody levels to see if the combo shot works as well as getting the vaccines separately.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Combination of a modified RNA COVID-19 vaccine and a recombinant influenza vaccine
What this could lead to: If successful, this could lead to a single annual shot that protects against both COVID-19 and flu, simplifying vaccination for older adults.
What could go wrong: This is an early-phase trial focused on safety and immune response, not yet on preventing illness. The combination may not work as well as separate shots, and side effects could be more common.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

COVID-19 prevention target influenza prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID-19 INFLUENZA, HUMAN SARS-COV-2 INFECTION

Contacts and locations

Locations

ActivMed Practices & Research, LLC.

Portsmouth, New Hampshire, 03801, United States
Bio-Kinetic Clinical Applications LLC DBA QPS-MO(Patient Screening Center)

Springfield, Missouri, 65807, United States
Bio-Kinetic Clinical Applications, LLC dba QPS-MO

Springfield, Missouri, 65802, United States
Bio-Kinetic Clinical Applications, LLD dba QPS-MO

Springfield, Missouri, 65802, United States
Centricity Research Columbus Ohio Multispecialty

Columbus, Ohio, 43213, United States
Charlottesville Medical Research

Charlottesville, Virginia, 22911, United States
Clinical Research Associates Inc

Nashville, Tennessee, 37203, United States
Clinical Research Atlanta

Stockbridge, Georgia, 30281, United States
Clinical Research Consulting

Milford, Connecticut, 06460, United States
Clinical Site Partners, LLC dba Flourish Research

Winter Park, Florida, 32789, United States
Clinical Trials of Texas, LLC

San Antonio, Texas, 78229, United States
DM Clinical Research - Bellaire

Houston, Texas, 77081, United States
DM Clinical Research - MDC

Tomball, Texas, 77375, United States
DM Clinical Research- Cyfair

Houston, Texas, 77065, United States
Diablo Clinical Research, Inc.

Walnut Creek, California, 94598, United States
East-West Medical Research Institute

Honolulu, Hawaii, 96814, United States
GW Medical Faculty Associates

Washington D.C., District of Columbia, 20037, United States
GW Vaccine Research Unit

Washington D.C., District of Columbia, 20037, United States
Headlands Research Orlando

Orlando, Florida, 32819, United States
IMA Clinical Research San Antonio

San Antonio, Texas, 78229, United States
Indago Research & Health Center, Inc

Hialeah, Florida, 33012, United States
JEM Research Institute

Atlantis, Florida, 33462, United States
Las Vegas Clinical Trials

Las Vegas, Nevada, 89030, United States
Las Vegas Clinical Trials

North Las Vegas, Nevada, 89030, United States
Optimal Research

Melbourne, Florida, 32934, United States
Optimal Research

Peoria, Illinois, 61614, United States
Orange County Research Center

Lake Forest, California, 92630, United States
Orange County Research Center

Tustin, California, 92780, United States
Rochester Clinical Research, LLC

Rochester, New York, 14609, United States
SMS Clinical Research

Mesquite, Texas, 75149, United States

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