New COVID-19 vaccine boosters target latest variants in large trial
NCT ID NCT05997290
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested updated versions of the Pfizer-BioNTech COVID-19 vaccine designed to target newer Omicron variants (XBB.1.5, JN.1, and KP.2). Over 1,000 healthy people aged 12 and older received a single dose. The main goals were to check safety and measure the immune response. The trial is now complete.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
BNT162b2 mRNA vaccine (updated for Omicron XBB.1.5, JN.1, and KP.2 variants)
What this could lead to
If successful, these updated vaccines could provide better protection against newer COVID-19 variants.
What could go wrong
This is a completed Phase 2/3 trial, but results may not apply to future variants. Side effects like injection site pain and fatigue are common.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Acevedo Clinical Research Associates
Miami, Florida, 33142, United States
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Alliance for Multispecialty Research, LLC
Mobile, Alabama, 36608, United States
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Alliance for Multispecialty Research, LLC
Tempe, Arizona, 85281, United States
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Alliance for Multispecialty Research, LLC
Knoxville, Tennessee, 37909, United States
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Alliance for Multispecialty Research, LLC
Knoxville, Tennessee, 37920, United States
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Alliance for Multispecialty Research, LLC
Layton, Utah, 84041, United States
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Alliance for Multispecialty Research, LLC
Norfolk, Virginia, 23502, United States
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Bayview Research Group, LLC
Valley Village, California, 91607, United States
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Bio-Kinetic Clinical Applications LLC DBA QPS_MO (Patient Screening Only)
Springfield, Missouri, 65807, United States
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Bio-Kinetic Clinical Applications, LLC dba QPS-MO
Springfield, Missouri, 65802, United States
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California Research Foundation
San Diego, California, 92123, United States
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Care Research - West Flagler Street
Miami, Florida, 33130, United States
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Centricity Research Columbus Ohio Multispecialty
Columbus, Ohio, 43213, United States
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Clinical Neuroscience Solutions Inc.
Memphis, Tennessee, 38119, United States
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Clinical Neuroscience Solutions, Inc.
Orlando, Florida, 32801, United States
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Clinical Neuroscience Solutions, Inc. dba CNS Healthcare
Jacksonville, Florida, 32256, United States
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Clinical Research Atlanta
Stockbridge, Georgia, 30281, United States
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Clinical Research Consulting
Milford, Connecticut, 06460, United States
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DM Clinical Research
Tomball, Texas, 77375, United States
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DM Clinical Research - Bellaire
Houston, Texas, 77081, United States
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Dayton Clinical Research
Dayton, Ohio, 45409, United States
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Diablo Clinical Research, Inc.
Walnut Creek, California, 94598, United States
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East-West Medical Research Institute
Honolulu, Hawaii, 96814, United States
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Epic Medical Research - DeSoto
DeSoto, Texas, 75115, United States
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Epic Medical Research - Surprise
Surprise, Arizona, 85378, United States
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IMA Clinical Research San Antonio
San Antonio, Texas, 78229, United States
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Indago Research & Health Center, Inc
Hialeah, Florida, 33012, United States
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J. Lewis Research, Inc. / Foothill Family Clinic
Salt Lake City, Utah, 84109, United States
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J. Lewis Research, Inc. / Foothill Family Clinic South
Salt Lake City, Utah, 84121, United States
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Kentucky Pediatric/ Adult Research
Bardstown, Kentucky, 40004, United States
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M3 Wake Research, Inc.
Raleigh, North Carolina, 27612, United States
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Medical Affiliated Research Center
Huntsville, Alabama, 35801, United States
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North Alabama Research Center
Athens, Alabama, 35611, United States
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SMS Clinical Research
Mesquite, Texas, 75149, United States
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Senders Pediatrics
South Euclid, Ohio, 44121, United States
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West Coast Research
Dublin, California, 94568, United States
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Zenos Clinical Research
Dallas, Texas, 75230, United States