COVID-19

This early-stage trial tests a new booster vaccine called Boost-2867 in 140 healthy adults who have already been vaccinated against COVID-19. The vaccine is given either as a shot with or without adjuvants (ingredients that boost immune response) or as a nasal spray without adjuv…

This study tests an experimental oral COVID-19 vaccine tablet (VXA-CoV2-3.3) against approved mRNA booster shots in about 5,500 adults who have already been vaccinated. The goal is to see if the tablet can prevent symptomatic COVID-19 as well as or better than the injectable vacc…

This early-stage trial tests a new COVID-19 booster vaccine called Prime-2-CoV_Beta, made from a modified orf virus. It involves 96 healthy adults aged 18-55 who have already been vaccinated or infected. The main goal is to check safety and how well the vaccine boosts the immune …

This study tests whether training popular community leaders to share vaccine information can increase COVID-19 booster shots among Black individuals with rheumatic conditions like lupus. About 60 people will take part, including leaders and their social network members. The goal …

This early-stage trial tests a new type of COVID-19 booster vaccine called PepGNP-COVID19. It uses tiny gold nanoparticles to train the immune system's T cells to recognize and fight the virus. The study involves 60 healthy adults aged 18-64 who will receive one of three doses to…

This study tests a single dose of an updated Novavax COVID-19 vaccine designed to target the JN.1 variant. About 6,500 healthy adults aged 50 to under 65 who are not at high risk for severe COVID will receive either the vaccine or a placebo. Researchers will track how well the va…

This large study is testing updated mRNA vaccines designed to protect against newer Omicron variants of COVID-19 in healthy children aged 6 months to 12 years. Over 4,000 participants will receive one or more doses depending on their age and vaccination history. Researchers are m…

This study tests a variant-adapted COVID-19 vaccine in about 5,240 healthy adults aged 50 to 64. Half receive the vaccine, half a placebo, to see if it safely prevents COVID-19 caused by new virus variants. The goal is to find out how well the updated shot works in this age group…

This large study tests whether an updated Moderna COVID-19 vaccine can prevent severe COVID-19 in adults aged 50 to 64 who have no health conditions that raise their risk. About 285,000 participants will be randomly assigned to get the vaccine or not. The main goal is to see if t…

This Phase 3 trial tests an updated COVID-19 vaccine (BNT162b2, 2025/2026 formulation) in 343 children aged 5 to 11 who have medical conditions that put them at high risk for severe COVID-19. All participants receive one dose and are monitored for about 6 months to check safety a…

This study tests two different COVID-19 vaccines—Moderna's bivalent mRNA and Novavax's protein-based—as a fourth booster dose in healthy adults who have already had three doses. Researchers will check how well each vaccine boosts the immune system and track any side effects. The …

This study tests a single-dose nasal spray COVID-19 vaccine (CVXGA) against a standard mRNA shot in about 432 healthy adults who have already had a primary COVID-19 vaccine series. The goal is to see if the nasal vaccine is safer and better at preventing symptomatic COVID-19 over…

This study tests a new COVID-19 vaccine given as a nasal spray. It aims to see if the spray is safe and helps the body fight the virus. About 227 healthy adults aged 18 to 80 will take part. The vaccine is designed to boost immunity in the nose, where the virus often enters.

This was an early safety study for a personalized COVID-19 vaccine. The vaccine would have been made using each participant's own immune cells, trained in a lab to recognize the coronavirus. The study was withdrawn before any participants were enrolled, so no results are availabl…

This study tests a non-invasive pneumatic vest designed to apply pressure to the chest wall in patients with acute respiratory distress syndrome (ARDS) caused by COVID-19 who are on mechanical ventilators. The goal is to see if the vest can improve oxygen levels in the blood. Up …

This study was designed to see if corticosteroids (prednisone or hydrocortisone) could help COVID-19 patients who need extra oxygen. It planned to enroll adults with confirmed COVID-19 and pneumonia, using CT scans to identify those likely to benefit. However, the trial was withd…

This early-stage trial tests a biologic treatment for 20 people with moderate COVID-19 who also have controlled cancer. The treatment aims to help the immune system recognize and kill the virus. Researchers will check if the virus clears and if the immune response improves.

This phase 2 trial tests a nasal spray called Optate in 24 adults with mild COVID-19. The spray aims to lower virus levels in the nose and improve symptoms like congestion. Participants receive either Optate or a placebo, and researchers measure changes in virus levels and sympto…

This phase 2 trial tests whether N-acetylcysteine, a drug already used for acetaminophen overdose and lung mucus, can help severe COVID-19 patients by boosting their immune system. About 48 critically ill adults will receive the drug alongside standard care. The goal is to see if…

This study tests whether a probiotic called Lactobacillus plantarum 299v (Lp299v) can improve blood vessel function in people with Long COVID (PASC). The trial includes 80 adults who had COVID-19 30-180 days ago and have ongoing symptoms. Participants take either the probiotic or…

This trial tests a device called Seraph 100, a blood filter used to treat severe COVID-19. The goal is to see if filtering the blood can reduce organ failure in patients with COVID-19 who are in the intensive care unit. The study enrolled 42 adults with confirmed COVID-19 and org…

This phase 2 trial tests whether a single, low dose of radiation to the chest can reduce lung inflammation in hospitalized COVID-19 pneumonia patients. Researchers compare two radiation doses (35 cGy and 100 cGy) to standard care. The goal is to see if this treatment lowers the n…

This study tests several experimental treatments at once in critically ill COVID-19 patients who need high-flow oxygen or a ventilator. The goal is to quickly find which treatments can reduce deaths and shorten the time patients need breathing support. About 1,500 adults in the h…

This study planned to test a new stem cell product (BX-U001) in people with severe COVID-19 pneumonia and moderate to severe lung failure (ARDS). The goal was to check safety and find the best dose. However, the study was withdrawn before enrolling any participants, so no results…

This study tests if inhaling a protein called interferon beta 1b can help hospitalized COVID-19 patients who need oxygen. The goal is to see if the treatment reduces the amount of oxygen they need over 15 days. The study includes 74 adults with confirmed COVID-19 who are on oxyge…

This study aimed to see if the drug sarilumab could help hospitalized COVID-19 patients with severe breathing distress. It planned to compare one or two doses of sarilumab against a placebo. However, the study was withdrawn before enrolling any participants, so no results are ava…

This study tests two new devices (imPulse Una and TOR) that use sound waves to detect COVID-19, flu, and RSV without needles or swabs. About 300 adults with or without symptoms will have a quick, painless scan. The goal is to see if these e-stethoscopes can accurately identify th…

This study tests a new drug called VYD2311, a monoclonal antibody that blocks the COVID-19 virus from entering cells. About 1,770 adults and teens aged 12 and older receive either VYD2311 or a placebo as a monthly shot for 3 months. The goal is to see if it safely prevents COVID-…

This study aimed to see if hydroxychloroquine could prevent COVID-19 hospitalizations in adults on dialysis for kidney failure. It was designed as a randomized trial but was withdrawn before enrolling any participants. No results are available.

This study aimed to see if the BCG vaccine, originally for tuberculosis, could reduce the severity of COVID-19 in healthcare workers in Medellín, Colombia. It planned to give a single dose of BCG or a placebo to 0 participants (doctors, nurses, and nursing assistants) who were di…

This study aims to see if health communication campaigns and added community support can increase COVID-19 vaccination rates in 15 rural Kentucky counties. About 2,250 adults will take part, with some counties getting only messages and others getting extra help like transportatio…

This phase 3 trial tests whether taking Paxlovid (nirmatrelvir/ritonavir) during acute COVID-19 can prevent long COVID. About 2,000 adults aged 18-64 with a recent positive test and symptoms will receive either Paxlovid or a placebo for 5 days. Researchers will track long COVID s…

This study aimed to see if hydroxychloroquine could prevent COVID-19 in older adults living in long-term care homes. It planned to give either the drug or a placebo to high-risk residents after they were exposed to the virus. However, the trial was withdrawn before enrolling anyo…

This study tests whether a diet rich in fermented foods (like yogurt and kimchi) is tolerable and can improve quality of life for survivors of critical illness, including severe COVID-19. The goal is to help restore gut health and reduce inflammation. The study involves 40 partic…

This study tests whether a 10-week aerobic exercise program can improve physical function and reduce symptoms in adults still struggling after a COVID-19 infection. Participants will exercise three times a week and attend weekly education classes. The goal is to see if exercise h…

This study tests a personalized health pathway for 400 people with persistent COVID-19 symptoms lasting more than 12 weeks. Participants receive nurse follow-up and can choose workshops on disease management, anxiety, and fatigue. The goal is to see if this approach improves qual…

This study looks at whether joining community drum circles and mindfulness programs can help reduce anxiety and depression in Black and other marginalized groups who faced extra stress during COVID-19. About 90 people aged 16 and older will take part. Researchers will measure how…

This study tests whether a virtual, community-based program combining music and mindfulness can help reduce stress, anxiety, and depression in people of African descent. About 300 participants aged 16 and older will take part. The goal is to see if these culturally relevant activ…

This study planned to test TADIOS, a blend of three herbs used in traditional Asian medicine, as an add-on treatment for adults hospitalized with mild to moderate COVID-19. Participants would have received TADIOS or a placebo for up to 10 days. The goal was to see if TADIOS could…

This study asks over 1,600 African American women aged 23-35 about their experiences during the COVID-19 pandemic. Participants fill out a short online or paper survey covering infection, vaccination, childcare, job loss, and emotional stress. The goal is to understand how the pa…

This early-stage study is testing a new tablet version of the COVID-19 drug ibuzatrelvir in 18 healthy adults. Researchers want to see how much of the drug gets into the blood when taken as a whole tablet, dispersed in water, or with food. The goal is to compare the new tablet to…

This study tracks 80 adults with different smell disorders (like total loss, partial loss, or distorted smell) plus healthy volunteers over one year. Researchers use brain scans, smell tests, and questionnaires to see how the brain changes and how smell loss impacts mood and dail…

This study tests a new AI-powered toolkit designed to help public health officials at local CDC offices respond more quickly to emerging infectious diseases such as COVID-19, mpox, influenza, and dengue. The toolkit combines data analysis, risk assessment, decision support, and e…

This study tests whether training primary care providers on how to talk to patients about vaccines can increase flu and COVID-19 vaccination rates. Over 24,500 patients and their doctors at multiple clinics will take part. Doctors in some clinics will receive special communicatio…

This pilot study tracks 24 adults who were hospitalized for COVID-19. Researchers use diaphragm ultrasound to see how well the main breathing muscle works 3 and 6 months after leaving the hospital. The goal is to describe long-term breathing changes, not to test a treatment.

This study aimed to see if the antibiotic doxycycline could protect people from severe COVID-19. Researchers planned to analyze health records of patients who took doxycycline for acne during the pandemic. However, the study was withdrawn before enrolling any participants, so no …

This study follows 583 adults who recovered from COVID-19 or were close contacts. Researchers will track their health, mental well-being, and immune responses over 3 years to understand long-term effects and whether prior infection prevents reinfection. Participants undergo regul…

This study looks at how COVID-19 impacts people with hepatocellular carcinoma, a type of liver cancer. Researchers will track infection rates and see how the virus affects liver function, cancer treatment, and overall health. About 23 participants from a French national liver can…

This study tracked 81 critically ill COVID-19 patients admitted to a French intensive care unit. Researchers compared factors like age, medical history, and treatments to understand who becomes severely ill. The goal is to improve care for future patients.

This study examines whether the COVID-19 pandemic increased frailty and muscle loss (sarcopenia) in people waiting for a liver transplant. Researchers will compare data from 208 patients assessed before and during the pandemic. The goal is to understand how the pandemic affected …

This study planned to test telemonitoring for older adults (75+) in nursing homes with confirmed or probable COVID-19. The goal was to see if remote monitoring could improve healthcare management and reduce deaths within 30 days. However, the study was withdrawn before enrolling …

This study is testing whether a computer can automatically measure how much lung tissue is damaged in patients with severe breathing problems from COVID-19 or after surgery. Researchers will compare the computer's lung measurements to standard severity scores in 500 patients. The…

This study follows 1,520 mostly Black and Latino individuals and their households who had COVID-19 in New York City. Researchers will use surveys and medical records to track long-term health problems, and for 500 hospitalized patients, they will collect nasal swabs and blood sam…

This study examines tissue from people who died after a COVID-19 infection to understand why some develop Long COVID. Researchers will look for signs of inflammation, scarring, blood clots, and tissue death in the body. The goal is to learn more about the long-term effects of the…

This study collects blood samples and medical information from 201 adults diagnosed with COVID-19. The goal is to create a resource that researchers can use to study the virus and improve understanding of the disease. Participants provide samples and allow their health data to be…

This study is a medical registry that follows over 21,000 adults hospitalized in 2021 at a Russian hospital. Researchers will analyze their health records, including chronic conditions, COVID-19 history, and outcomes like heart attacks or strokes, over five years. The goal is to …

This study looks at heart problems in adults hospitalized with COVID-19. Researchers will review medical records to see how often heart issues like heart failure, inflammation, or arrhythmias occur. No new treatments are tested; the goal is to learn more about the virus's effects…

This study aims to understand why people who use drugs in Baltimore may be hesitant to get a COVID-19 vaccine. Researchers will interview 40 participants about their views and barriers to vaccination. The goal is to improve vaccine access and acceptance in this community.

This study tests whether AI-powered X-ray analysis and portable molecular tests can help find tuberculosis (TB) and COVID-19 cases in African communities where many cases go undetected. Over 26,000 adults will be screened using these tools, and researchers will measure how quickl…

This study compares how well two FDA-approved COVID-19 vaccines—Novavax (a protein-based vaccine) and Pfizer (an mRNA vaccine)—trigger the immune system. Researchers will measure antibody levels against several virus variants in 54 healthy adults aged 18-79 who have risk factors …

This study looks at why more than half of people who recover from COVID-19 still feel very tired. Researchers are measuring fatigue in 398 adults using questionnaires and muscle tests. The goal is to better understand who is most affected and how severe the fatigue can be.

This study aims to create a test that predicts how hospitalized COVID-19 patients will fare in the short and long term (up to one year). Researchers will enroll 600 adults from hospitals and Veterans' facilities, using medical records and lab data to forecast risks like frailty, …

This study is monitoring the safety of the Pfizer-BioNTech COVID-19 vaccine (BNT162b2) in 12,000 people in South Korea who received the vaccine as part of routine care. Researchers are tracking side effects like sore arms or fever within a week of each dose, as well as any other …

This study looks at whether temporarily reducing immunosuppressive medication can help kidney transplant recipients mount a stronger immune response to a third dose of the COVID-19 mRNA vaccine. Fourteen participants with low or no antibodies will have their antimetabolite dose l…

This study follows about 1,000 adults in the U.S. who test positive for COVID-19 or influenza. Participants fill out surveys about their symptoms and quality of life over six months. The goal is to understand how these illnesses affect daily activities and whether COVID-19 vaccin…

This study collected data from 7,500 adults admitted to Swedish ICUs with COVID-19 during the first two years of the pandemic. Researchers looked at patient characteristics, treatments, and survival rates at 30 days and one year. The goal is to understand the disease's impact and…

This study looks at how adults feel after getting either the Novavax or the mRNA COVID-19 booster vaccine. Researchers will track symptoms like fever, fatigue, and headache for a week after vaccination. The goal is to help people understand which vaccine might cause fewer reactio…

This study explores whether listening to recordings of communal drumming, combined with mindfulness, can reduce stress and improve mental health in People of African Descent. Researchers will measure feelings of connection and synchrony in 30 adults. The goal is to see if cultura…

This study looks at how doctors and nurses in radiation oncology used telehealth instead of in-person visits during the COVID-19 pandemic. Researchers will survey 1,000 healthcare providers at Duke Cancer Center to understand their experiences and challenges. They will also track…

This study looks at blood samples from 83 adults in Maryland who have recovered from COVID-19. Researchers want to understand how specific immune cells called CD8 T cells respond to the virus and how this changes with age. The goal is to gather knowledge that could help create be…

This study will safely give a small dose of the Delta COVID-19 virus to 20 healthy adults aged 21-30 in Singapore. The goal is to see if the virus causes infection and to check for side effects. This 'human challenge' model could help test future vaccines and treatments faster.

This registry enrolls people who have recovered from COVID-19 to create a pool of volunteers for future studies on immunity, vaccines, and plasma donation. Over 5,000 participants are included. No treatment is given; it is purely for research.

This study follows 500 ICU patients to compare long-term mental and physical health between those with and without COVID-19. Researchers use surveys and tests to measure quality of life, thinking skills, and emotional well-being. The goal is to identify specific problems caused b…

This study looks at how the immune systems of younger and older adults respond to Pfizer or Moderna COVID-19 vaccines. Researchers will collect blood samples from 78 healthy volunteers over two years to measure specific T-cell responses. The goal is to understand if age changes h…

This study looks at how having intestinal worms (helminths) and COVID-19 antibodies changes the immune system and gut bacteria. Researchers will collect blood and stool samples from 1500 people in India to measure infections and immune markers. The goal is to understand these int…

This study is building a large group of people living in the US who are willing to be contacted about future research, especially on COVID-19. Participants sign up online and share health information through surveys. The goal is to create a ready pool of volunteers for upcoming s…

This study looks at how well the yearly updated Pfizer COVID-19 vaccine works in adults and children. Instead of giving anyone the vaccine, researchers will analyze existing insurance claims and state vaccine records. They will compare people who got the vaccine to those who did …

This study looks at how COVID-19 changes the bacteria in the gut of hospitalized patients. Researchers will collect stool samples from 15 patients to measure the virus in feces and see if these changes relate to how sick patients become. The goal is to better understand the link …

This study examines whether people with certain blood cancers (myeloproliferative neoplasms) have autoantibodies that block a key immune protein called type I interferon. These autoantibodies may increase the risk of severe COVID-19. Researchers will test blood samples from 219 p…

This study looks at how having a penicillin allergy record affects treatment and antibiotic resistance in patients hospitalized with COVID-19. Many people labeled as allergic to penicillin are not truly allergic, leading to use of less effective antibiotics that can drive resista…

This study planned to track patients who had been in the intensive care unit for severe COVID-19, checking for long-term health problems like breathing, heart, kidney, and nerve issues. Researchers would have used questionnaires and doctor visits over 12 months. However, the stud…

This study looks at whether people can reliably collect their own blood and saliva samples at home to measure how well COVID-19 vaccines work. About 4,000 adults who recently got a COVID-19 vaccine will either do everything remotely or visit a clinic. Researchers will compare the…

This study looks at whether problems with blood vessels in the lungs cause ongoing shortness of breath in people who had COVID-19. Researchers will use heart and lung tests, including exercise and imaging, in 200 adults. The goal is to better understand why some people feel breat…

This study examines how the COVID-19 pandemic affected syphilis cases and their interaction with HIV. Researchers will review medical records of 240 adults diagnosed with syphilis in Italy between 2017 and 2025. The goal is to see if pandemic restrictions led to delayed diagnoses…