COVID - 19

This study tests whether a COVID-19 vaccine (mRNA-1273) can prevent severe illness in healthy adults aged 50-64 who have no known risk factors. About 285,000 participants will be randomly assigned to receive the vaccine or no vaccine. The main goal is to see if the vaccine reduce…

This study tests whether an updated COVID-19 vaccine can safely protect healthy adults aged 50 to 64 from the virus. About 5,240 participants will receive either the variant-adapted vaccine or a placebo. Researchers will monitor side effects and track how many people get COVID-19…

This study tests an updated COVID-19 vaccine designed for the 2025-2026 season. It includes 760 people aged 12 and older who are at higher risk of severe COVID-19, such as those with underlying health conditions or aged 65+. Participants receive one shot, and researchers monitor …

This study tests a new COVID vaccine given as a single nasal spray. It aims to see if the spray is safe and boosts the body's immune defenses against the virus. About 227 healthy adults aged 18 to 80 are taking part. The vaccine is designed to work where the virus enters the body…

This study tests a new vaccine designed to protect against the Omicron JN.1 variant of COVID-19. About 120 adults aged 65 and older, or those aged 12-64 with health conditions that raise their risk, will receive one shot. Researchers will check how well the vaccine boosts immunit…

This study tests a new combination vaccine that aims to protect against both COVID-19 and the flu with a single shot. It involves about 9,300 adults aged 65 and older, who will receive either the combo vaccine or a standard high-dose flu vaccine. Researchers will compare immune r…

This study tests an experimental oral COVID-19 vaccine tablet against a standard mRNA booster shot. About 10,400 adults who have already had at least two mRNA vaccine doses will take part. The goal is to see if the tablet can prevent symptomatic COVID-19 as well as or better than…

This study looked at whether temporarily reducing immunosuppressive medication in kidney transplant recipients could improve their immune response to a third dose of the COVID-19 mRNA vaccine. Fourteen participants with low or no prior antibody levels were enrolled. The main goal…

This study tests two different COVID-19 booster vaccines—Moderna's bivalent mRNA and Novavax's protein-based—in 496 healthy adults who have already had three doses. The goal is to see which booster produces a stronger immune response and causes fewer side effects. Participants wi…

This early-stage trial tests a new booster vaccine, STX-S, for COVID-19. About 60 healthy adults who have already received a primary vaccine series and at least one booster will get a single shot of STX-S at one of three dose levels. The main goal is to check safety and how well …

This early-stage study tests a new COVID-19 booster vaccine called PepGNP-COVID19 in 60 healthy adults aged 18-64. Unlike current vaccines, it uses tiny gold particles to train the body's T-cells to recognize and attack the virus, potentially providing broader and longer-lasting …

This study tests an updated COVID-19 vaccine in healthy children aged 6 months to 12 years. The goal is to see if the vaccine is safe and triggers a strong immune response. Children who have or haven't had a COVID-19 vaccine before can join. The study will track side effects and …

This study compares a single-dose nasal spray COVID-19 vaccine (CVXGA) to a standard mRNA shot (Comirnaty) in about 432 healthy adults who have already had a primary COVID-19 vaccine series. The goal is to see if the nasal vaccine is safer and better at preventing symptomatic COV…

This study tests an updated COVID-19 vaccine (2025/2026 formula) in 343 children aged 5 to 11 who have health conditions that make them more likely to get very sick from COVID-19. Each child gets one shot in the arm and is followed for about 6 months. The goal is to see if the va…

This was an early safety study for a personalized COVID-19 vaccine. The vaccine would have been made using each participant's own immune cells, trained in a lab to recognize the coronavirus. The study was withdrawn before any participants were enrolled, so no results are availabl…

This study tests whether a single low-dose radiation treatment to the lungs can reduce inflammation in adults hospitalized with COVID-19 pneumonia. The goal is to see if this approach lowers the need for a breathing tube or shortens hospital stays. About 37 participants will rece…

This study tests several experimental drugs at once in critically ill COVID-19 patients who need high-flow oxygen or a ventilator. The goal is to quickly find which treatments can reduce deaths and shorten the time on a breathing machine. About 1,500 adults in the hospital are pa…

This study aimed to test whether an experimental drug called TADIOS could help people hospitalized with mild to moderate COVID-19 recover faster. It was designed for adults aged 18 to 65 who had a confirmed first-time COVID-19 infection. However, the trial was withdrawn before en…

This study tests whether a probiotic called Lp299v can improve blood vessel function in people with long COVID (PASC). The trial involves 80 adults who had COVID-19 in the past 30-180 days and now have long COVID symptoms. Researchers will measure blood vessel health using ultras…

This study uses health records from nearly 99,000 adults in Ontario to see if the antiviral drug Paxlovid reduces the risk of severe COVID-19 outcomes like hospitalization or death. Researchers compared people who took Paxlovid with those who did not, tracking their health for up…

This study tested a device called Seraph 100, a blood filter designed to remove the COVID-19 virus from the bloodstream. It involved 42 adults with severe COVID-19 and organ failure. The goal was to see if the filter could reduce organ damage and improve survival.

This study tests whether N-acetylcysteine, a drug already used for liver protection and mucus thinning, can help people with severe COVID-19. The idea is that it may boost the immune system to fight the virus better. About 48 adults with severe or critical COVID-19 will receive t…

This study aimed to see if the drug sarilumab could help hospitalized COVID-19 patients with severe breathing problems. It planned to compare a single or double dose of sarilumab against a placebo. However, the study was withdrawn before enrolling any participants, so no results …

This study tests whether inhaling a protein called interferon beta 1b can help hospitalized COVID-19 patients who need oxygen. The goal is to see if it reduces how much oxygen they require over 15 days. The trial involves 74 adults with confirmed COVID-19 who are on oxygen therap…

This study aimed to test the safety and effects of an experimental stem cell treatment (BX-U001) for adults hospitalized with severe COVID-19 pneumonia and serious breathing problems (ARDS). The trial was designed in two parts: first to find a safe dose, and then to compare that …

This study tests two new devices that use sound waves to detect COVID-19, flu, and RSV without needles or swabs. About 300 adults will have a quick, painless scan and answer a symptom questionnaire. The goal is to see if these tools can accurately identify infections, even in peo…

This study aimed to see if the BCG vaccine, originally for tuberculosis, could help healthcare workers fight off severe COVID-19. Researchers planned to vaccinate doctors and nurses in Medellín, Colombia, and track how many got sick. However, the study was withdrawn before any pa…

This study looks at whether special health messages or adding local support can increase COVID-19 vaccination rates in 15 Kentucky counties. About 2,250 adults from underserved areas will take part. The goal is to find the best ways to help communities protect themselves from COV…

This study tests whether taking Paxlovid early during a COVID-19 infection can prevent long-COVID symptoms like fatigue, shortness of breath, and brain fog. About 2,000 adults aged 18-64 with a recent positive test and symptoms will receive either Paxlovid or a placebo. Researche…

This study aimed to see if hydroxychloroquine (HCQ) could safely prevent COVID-19 in older adults living in long-term care homes who were at high risk. It planned to give the drug to people after they were exposed to the virus. However, the study was withdrawn before any particip…

This study tests a health pathway designed to help people with persistent COVID-19 symptoms (long COVID) improve their quality of life. Researchers will follow 400 participants for 6 months, measuring physical, mental, and social well-being. The goal is to see if structured suppo…

This study looks at whether a 10-week exercise program can help adults who still have symptoms after a COVID-19 infection. Participants will do cardio exercise three times a week and attend weekly education classes. The goal is to see if exercise improves physical function and re…

This study looks at whether joining a drum circle can help reduce anxiety and depression in people of African descent who are dealing with stress from COVID-19. About 90 people aged 16 and older will take part. Researchers will measure how absorbed they feel in the music and any …

This study looks at whether a virtual program combining music and mindfulness can reduce stress, anxiety, and depression in people of African descent. About 300 participants aged 16 and older will take part. The goal is to see if culturally relevant, community-based activities im…

This study looks at how the COVID-19 pandemic changed the number and severity of syphilis cases in 240 patients treated at an Italian hospital between 2017 and 2025. Researchers will compare syphilis trends before and after the pandemic and explore its connection with HIV. The go…

This study collected information on 7,500 adults with COVID-19 who were treated in Swedish intensive care units (ICUs) during the first two months of the 2020 pandemic. Researchers looked at patient backgrounds, treatments, and survival rates to understand what factors increased …

This study examines whether people with certain blood cancers (MPN) have autoantibodies that block a key immune protein called interferon. Researchers want to see how common these autoantibodies are and if they make COVID-19 more severe. About 219 participants will give a blood s…

This study follows about 1,000 adults with confirmed COVID-19 or flu to see how their symptoms and quality of life change over six months. Participants fill out surveys about their health, daily activities, and vaccine history. No treatment is given; the goal is to better underst…

This study follows 1,520 mostly Black and Latinx adults in New York City who had COVID-19 to understand long-term health problems. Participants complete surveys about symptoms and allow researchers to review their medical records. A smaller group also provides blood and nasal swa…

This study looks at insurance and vaccine records to see how well the yearly updated COVID-19 vaccines protect adults and children. Researchers will compare people who got the vaccine to those who did not, tracking doctor visits, emergency care, and hospital stays. No one receive…

This study looks at how having intestinal worms (helminths) and COVID-19 antibodies changes the immune system and gut bacteria. Researchers will collect blood and stool samples from 1500 people in India. The goal is to better understand these interactions, not to test a treatment…

This study surveys radiation oncology doctors and staff at Duke Cancer Center to understand their experience using telehealth instead of in-person visits during the COVID-19 outbreak. Researchers will track how many virtual visits were missed and whether patients ended up in the …

This study follows 500 adults who were in the ICU with breathing failure—some had COVID-19, some did not. Researchers want to see if COVID-19 leads to different long-term mental and physical problems. The goal is to better understand and treat these lasting effects.

This study gives a carefully controlled dose of the Delta COVID-19 virus to 20 healthy adults aged 21-30 who are already vaccinated. The goal is to safely create a mild infection in most participants so researchers can study how the virus spreads and how the body fights it. This …

This study looks at how COVID-19 changes the bacteria in the gut of hospitalized patients. Researchers want to see if the amount of virus in stool is linked to symptoms and how the disease progresses. The goal is to better understand the role of gut health in COVID-19, not to tes…

This study aims to find out if lung blood vessel damage is causing ongoing shortness of breath in people who had COVID-19. Researchers will study 200 adults who had COVID-19 3 to 18 months ago, using breathing tests, heart ultrasounds, and other exams. The goal is to better under…

This study tests whether computer-assisted X-rays and other simple tests can help find more cases of tuberculosis (TB) and COVID-19 in African communities. About 26,200 adults will be screened using these tools to see if they can detect cases that are usually missed. The goal is …

This study is building a registry of people living in the United States who are interested in participating in future research, especially about COVID-19. By signing up and completing surveys, you provide health information that researchers can use for upcoming studies. The goal …

This study asks young African American women (ages 23-35) who are already part of a long-term health study about their COVID-19 experiences. Participants fill out one online or paper survey (15-20 minutes) covering infection, vaccination, access to care, and how the pandemic affe…

This study talks to 40 people in Baltimore who recently used opioids to learn why they might be hesitant to get a COVID-19 vaccine. Researchers will use a simple survey to measure vaccine concerns. The goal is to find better ways to encourage vaccination in this community.

This study looks at how the immune system, specifically CD8 T-cells, responds to Pfizer or Moderna COVID-19 vaccines in healthy adults aged 18 and older. Researchers want to see if age affects this response. Participants do not receive the vaccine through the study but provide bl…

This study looks at whether people can collect their own blood and saliva samples at home to measure how well COVID-19 vaccines protect them. About 4,000 adults who recently got a COVID-19 vaccine will take part. Most will do everything remotely, while a small group will visit a …

This study looks at nearly 400 adults who had COVID-19 to understand their fatigue levels. Researchers use questionnaires and muscle tests to measure how tired people feel and how fatigue affects their daily life. The goal is to create a clear picture of who experiences long-term…

This study looks at anonymous health records from California and Louisiana to see if the Pfizer-BioNTech COVID-19 vaccine helps prevent post-COVID conditions (long COVID). Researchers will also track who gets vaccinated. The study includes adults with a COVID-19 diagnosis and use…

This study aims to create a test that can predict how hospitalized COVID-19 patients will fare in the short and long term (up to one year). Researchers will enroll 600 adults from hospitals and Veterans' populations, using both clinical data and molecular markers. The goal is to …

This study follows about 583 adults who have recovered from COVID-19 or were in close contact with someone infected. Researchers want to learn about any long-term medical problems that may appear after recovery and whether the body's immune response can prevent reinfection. Parti…

This study compares how people feel after getting either the Novavax or mRNA COVID-19 booster vaccine. About 1000 adults will report any symptoms like fever or fatigue for a week after vaccination. The goal is to help people choose the vaccine that works best for them.

This study aims to understand how the immune system fights COVID-19, especially in older adults. Researchers will analyze blood, urine, and saliva samples from 83 adults aged 18 and older who have recovered from COVID-19. The goal is to identify specific immune cells that target …

This study tests whether a virtual music and mindfulness program can help Black adults in the U.S. manage stress and feel more connected. Researchers will have 30 participants listen to drum circle recordings and rate their sense of connection and synchrony. The goal is to learn …

This study is tracking the safety of the BNT162b2 COVID-19 vaccine (including the bivalent version) in 12,000 people in Korea who received the vaccine as part of routine care. Researchers are collecting information on side effects that happen within a week and up to 28 days after…