COVID-19

This early-stage study is testing the safety and immune response of a new COVID-19 booster vaccine called PepGNP-COVID19. The vaccine uses tiny gold particles to deliver parts of the virus, aiming to train the body's T-cells for a strong and lasting defense, especially in the lun…

This study is monitoring the safety of the already-approved Pfizer COVID-19 vaccine in real-world use in Korea. It will follow 12,000 people who receive the vaccine as part of their normal healthcare, tracking any side effects they report for 28 days after each dose. The goal is …

This was an early safety study for a personalized COVID-19 vaccine. The vaccine would have been made using each participant's own immune cells, trained in a lab to recognize the coronavirus. The study was withdrawn before any participants were enrolled, so no results are availabl…

This study compares side effects between two different types of COVID-19 booster vaccines: the protein-based Novavax vaccine and newer mRNA vaccines. Researchers want to see if one type causes fewer symptoms like fever, fatigue, or headache in the week after vaccination. The goal…

This study is testing a new COVID-19 vaccine given as a single spray into the nose. Researchers want to see if it is safe and if it triggers a good immune response against the virus. The trial will include up to 400 healthy adults aged 18 to 80, some of whom have had prior COVID …

This study is comparing two different types of COVID-19 vaccines given as a fourth dose (booster shot) in healthy adults in Australia. About 500 participants who have already had three vaccine doses will receive either the Moderna mRNA vaccine or the Novavax protein-based vaccine…

This study aims to see how well the yearly updated versions of the Pfizer-BioNTech COVID-19 vaccine work in real-world conditions. Researchers will use existing, anonymous health insurance and state vaccination records to compare COVID-19 outcomes in vaccinated and unvaccinated a…

This study is testing a new oral COVID-19 vaccine in the form of a tablet. It aims to see if this pill is as effective and safe as the currently approved mRNA booster shots. The trial involves over 10,000 adults who have already been vaccinated against COVID-19.

This study is testing a new COVID-19 vaccine given as a single spray in the nose. It will compare this nasal spray to the currently approved mRNA shot to see if it is as safe and effective at preventing symptomatic COVID-19. The trial will enroll about 434 healthy adults and foll…

This study is testing the safety and immune response of a new COVID-19 vaccine designed to target the Omicron JN.1 variant. It will give a single booster dose to about 120 older adults and people with health conditions that put them at high risk for severe COVID-19. All participa…

This study is testing an updated COVID-19 vaccine designed for the 2025-2026 season in children aged 5 to 11 who have a medical condition that puts them at high risk for severe COVID-19. Researchers want to see how safe the vaccine is and how well it triggers an immune response. …

This early-stage study is testing the safety and immune response of a new COVID-19 booster vaccine called STX-S. Researchers will give 60 healthy adults who are already fully vaccinated one of three different low doses to see how their bodies react. The main goal is to find a saf…

This study is testing an updated COVID-19 vaccine designed for the 2025-2026 virus season. It aims to check the safety and how well it triggers an immune response. The trial is enrolling 760 people aged 12 and older who are at higher risk for severe COVID-19, including all adults…

This study aimed to test whether sarilumab, a medication used for rheumatoid arthritis, could help hospitalized COVID-19 patients with severe breathing difficulties. Researchers wanted to see if injections of this drug could reduce patients' need for oxygen support and improve ot…

This study aimed to test if a dietary supplement called TADIOS could help people with mild to moderate COVID-19 recover faster. It planned to give the supplement or a placebo (dummy pill) to 100 hospitalized patients for up to 10 days. The main goals were to see if it reduced sym…

This study is testing whether N-acetylcysteine, a medication already used for other conditions, can help the immune system fight severe COVID-19. Researchers are giving it to 48 hospitalized patients who are either in intensive care on a ventilator or need significant oxygen supp…

This trial aims to quickly identify treatments that can reduce deaths and the need for ventilators in critically ill COVID-19 patients. Using an adaptive platform design, it tests multiple investigational drugs simultaneously against current standard care. The study focuses on ho…

This study is testing whether inhaling a medication called interferon beta can help hospitalized COVID-19 patients who need oxygen. The goal is to see if this inhaled treatment can reduce how much oxygen support patients require over 15 days. The trial involves 74 adults with con…

This study uses real-world health records from Ontario to see if the COVID-19 treatment Paxlovid helps prevent severe outcomes like hospitalization or death. It compares the experiences of adults who received the drug at a pharmacy to those who did not, tracking their health for …

This study aimed to test the safety and effects of an experimental stem cell treatment (BX-U001) for adults hospitalized with severe COVID-19 pneumonia and serious breathing problems (ARDS). The trial was designed in two parts: first to find a safe dose, and then to compare that …

This study is testing whether a computer program that reads chest X-rays can help find cases of tuberculosis (TB) and COVID-19 more efficiently in communities in Africa. It will involve over 26,000 adults to see if using this artificial intelligence (AI) tool can speed up diagnos…

This study is testing new, non-invasive devices that listen to body sounds to detect COVID-19, flu, and RSV. It involves 300 adults, both with and without symptoms, who are already getting standard screening tests at a military medical center. The goal is to see if these AI-power…

This study aims to find the best community-based strategies to increase COVID-19 vaccination rates in Kentucky. Researchers will test whether health communication campaigns alone, or combined with local support programs, work better than standard care. The study involves about 15…

This large study is testing if taking the antiviral drug Paxlovid for a short time right after getting COVID-19 can prevent people from developing long-lasting symptoms, known as long COVID. About 2,000 adults in Norway with recent, confirmed COVID-19 will take either Paxlovid or…

This study is testing whether a new drug called VYD2311 can prevent people from getting COVID-19. About 1,770 adults and teens aged 12+ will receive three monthly shots of either VYD2311 or a placebo. Researchers will track who gets sick over 90 days to see if the drug lowers inf…

This study aimed to see if the drug hydroxychloroquine could prevent COVID-19 in older, high-risk adults living in care facilities after they were exposed to the virus. It was designed as a Phase 3 trial but was withdrawn before any participants were enrolled. The goal was to giv…

This study is testing whether a virtual, community-based program combining music, mindfulness, and drum circles can help Black adults manage stress, anxiety, and depression. Researchers want to see if feeling 'in sync' with others during drumming improves feelings of connection a…

This Yale University study is testing whether virtual, community-based programs that combine music and mindfulness can help Black adults manage stress, anxiety, and depression. The research focuses on creating culturally relevant support, an area often overlooked in past studies.…

This study is testing if participating in weekly community drum circles for 8 weeks can help reduce anxiety and increase feelings of connection. It focuses on including Persons of African Descent and other marginalized groups who are often left out of mental health research. Rese…

This study aims to understand how well COVID-19 vaccines work by measuring immune responses in blood samples. Researchers want to see if people can collect their own samples at home instead of visiting clinics, making research participation easier. The study follows 4,000 vaccina…

This study aims to understand how COVID-19 and influenza symptoms affect people's daily lives and health over time. It will follow 999 adults in the US who test positive for either virus and report having symptoms. Participants will fill out surveys about their symptoms, work, an…

This study aims to understand how the immune system, specifically certain white blood cells called CD8 T cells, responds to the COVID-19 virus in people who have recovered. Researchers are observing 83 adults in Maryland who previously tested positive for COVID-19 and are now sym…

This study aims to understand the long-term physical and mental health challenges faced by people who survive severe COVID-19 with respiratory failure. Researchers will follow 500 patients for up to a year after leaving the hospital, comparing them to other ICU patients without C…

This study aims to understand the long-term health problems people might have after recovering from COVID-19 and whether they develop lasting protection against getting it again. Researchers will follow 583 adults who either recovered from COVID-19 or were close contacts but didn…

This study aims to document the specific impact of the COVID-19 pandemic on young African American women and their families. Researchers are inviting about 1,668 women already enrolled in a long-term health study to complete a one-time, 20-minute survey. The survey asks about the…

This study aims to understand the long-term health of people who were critically ill with COVID-19 and needed intensive care in Sweden. Researchers are tracking the survival and new heart or lung problems in over 7,500 patients for up to a year after their ICU stay. They are also…

This study aims to understand why some patients with a group of blood cancers called MPNs experience severe COVID-19. Researchers are checking the blood of 219 MPN patients for specific proteins called autoantibodies that might weaken the body's early virus defense. The goal is t…

This study aims to understand why some people continue to experience shortness of breath and exercise limitation months after having COVID-19. Researchers will examine 200 adults who had COVID-19 3-18 months ago, comparing those with ongoing symptoms to those who have recovered. …

This study aims to understand how the immune system responds to COVID-19 vaccines in people of different ages. Researchers are observing 78 healthy adults who have received or plan to receive the Pfizer or Moderna vaccine. They will track specific immune cells in the blood over f…

This study looks at how cancer doctors use telehealth (video or phone visits) instead of in-person appointments during COVID-19. Researchers want to understand doctors' experiences with telehealth and whether it affects how often patients need emergency care. They'll compare resu…

This study is creating a large registry of people living in the United States who are interested in participating in future health research. It aims to build a community of 20,000 participants by collecting basic information and survey responses. The data will help researchers co…

This study aims to understand how common parasitic worm infections might affect people's immune response to COVID-19. Researchers will collect one-time blood and stool samples from 1,500 people in India to measure COVID-19 antibodies and check for worm infections. The goal is to …

This study uses existing health insurance and state vaccination records to answer two questions. First, it checks if the Pfizer-BioNTech COVID-19 vaccine helps prevent Long COVID symptoms that can last for months after infection. Second, it looks at the characteristics of people …

This study looks back at patient records to understand how the COVID-19 pandemic changed the spread of syphilis and its connection to HIV. Researchers are analyzing data from 240 patients treated at a hospital in Italy between 2017 and 2025. The goal is to see if lockdowns and re…

This study aims to safely infect a small group of healthy, vaccinated volunteers with the Delta variant of COVID-19. By carefully controlling the infection in a quarantine setting, researchers can closely study how the virus behaves and how the body responds. The goal is to creat…

This study aims to understand how COVID-19 infection changes the community of bacteria in the gut (the microbiome). Researchers will observe 15 hospitalized COVID-19 patients to see if the amount of virus in their stool is linked to changes in their gut bacteria and their overall…