Booster battle: moderna vs. novavax for fourth COVID shot
NCT ID NCT05658523
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests two different COVID-19 vaccines—Moderna's bivalent mRNA and Novavax's protein-based—as a fourth booster dose in healthy adults who have already had three doses. Researchers will check how well each vaccine boosts the immune system and track any side effects. The goal is to find out which booster is safer and more effective.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
COVID-19 vaccines (Moderna bivalent mRNA and Novavax protein-based)
What this could lead to
If successful, this could show which booster vaccine works best for a fourth dose, helping guide future vaccination strategies.
What could go wrong
This is a relatively small trial (496 people) and only measures short-term immune response and side effects, not long-term protection against infection or severe disease.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Royal Children's Hospital, Murdoch Children's Research Institute
Melbourne, Victoria, 3052, Australia