COVID-19

This study tests a new type of COVID-19 booster vaccine given as a nasal spray. The vaccine uses a weakened live virus to train the immune system, potentially offering stronger protection in the nose and throat where the virus enters. Researchers are enrolling 80 healthy adults a…

This phase 3 trial is testing whether the oral drug secutrelvir can help people with COVID-19 recover faster. The study involves about 1,200 nonhospitalized participants aged 12 to 75 who start treatment within 48 hours of symptom onset. Half will receive secutrelvir and half a p…

This Phase 3 trial tests whether dapagliflozin, a drug used for diabetes, can improve quality of life in people with long COVID. 192 adults with persistent symptoms for at least 12 weeks after a COVID infection will receive either the drug or a placebo daily for 12 months. The ma…

This early-stage trial tests a new drug called B10-FC, which is a lab-made antibody designed to fight the SARS-CoV-2 virus. The study will first give the drug to 25 healthy volunteers in increasing doses to check safety, then to 10 COVID-19 patients. The main goal is to see if th…

This study tests whether analyzing chemicals in a person's breath can quickly identify serious respiratory infections like COVID-19, flu, and Legionella in hospitalized patients. Researchers will collect breath samples from 777 adults using a simple bag, then analyze them in a la…

This study will test a new at-home diagnostic test that aims to detect five respiratory viruses—COVID-19, influenza A and B, RSV, and rhinovirus—from a single nose swab. About 2,000 people with cold or flu symptoms will provide samples in simulated home environments. The test's a…

This study tests two nasal protective devices (Noseguard and Noseguard Night) in 2000 adults to see if they can reduce the risk of catching respiratory infections like COVID-19 and influenza. Participants will use the devices as directed for 8 weeks, and researchers will track in…

This early-stage trial tests a single IV dose of placental stem cell vesicles (XoGlo Pro) against placebo in 64 adults with mild to moderate COVID-19. The main goal is safety, with a secondary focus on how quickly symptoms resolve. Researchers aim to see if these tiny cell partic…

This study follows people who had COVID-19 to see how long-term symptoms, known as long COVID, change over five years. Researchers will interview participants and assess their physical, mental, and cognitive health to understand the lasting impact of the infection. The goal is to…

This study uses a special PET scan to look for signs of inflammation in the brains of people with Post-COVID syndrome. Researchers want to learn more about why some people have long-lasting symptoms after a COVID-19 infection. Ten Mayo Clinic patients who had COVID-19 and are exp…

This study looks at 120 preterm infants born before 34 weeks to see if those born during the COVID-19 pandemic (2020-2021) develop differently than those born after (2023-2024). Researchers will test thinking, movement, and language skills using play-based assessments. The goal i…

This study looks back at the medical records of 50 adult ICU patients with COVID-19 who needed a life-support machine called ECMO. The goal is to understand how often bleeding and dangerous blood clots happen, and how blood transfusions and blood thinners affect their care. The f…

This study examines whether having COVID-19 increases the chance of lung inflammation (radiation pneumonitis) in breast cancer patients receiving radiation therapy. Researchers will review medical records of 200 patients to compare outcomes between those who had COVID-19 and thos…