COVID-19

This early-stage trial is testing a new COVID-19 booster vaccine called OCU500, which is given as a nasal spray or inhaled mist instead of a shot. The study involves 80 healthy adults aged 18-64 who have already been vaccinated against COVID-19. Researchers are checking if the va…

This study tests a new COVID-19 vaccine called VYD2311, given alone or together with an existing mRNA COVID-19 vaccine, in healthy adults aged 18 to 49. The goal is to check safety and measure the body's virus-fighting antibody levels. Participants receive one injection and are m…

This study tests an updated COVID-19 vaccine (mRNA-1283) designed to protect against current virus variants. About 832 people aged 12 and older, especially those at higher risk, will receive the vaccine. Researchers will measure immune response and monitor for side effects to ens…

This early-stage trial is testing a new nasal spray vaccine called COV2 against COVID-19. Twenty healthy adults who have already had at least two COVID-19 shots will receive two doses of one of two formulations. The study aims to check if the vaccine is safe and whether it boosts…

This study tests two ways to encourage COVID-19 vaccination among Latino adults and their friends in Maryland. One group learns motivational interviewing skills to talk about vaccines, while the other just gets vaccine information. Researchers will compare how many friends get va…

This Phase 2a trial tests a new nasal COVID-19 vaccine (NDV-HXP-S-KP.2) against an approved mRNA shot in 200 adults who have already been vaccinated. The goal is to see if the nasal vaccine is safe and tolerable. Participants are either 65 or older, or 18-64 with a condition that…

This study is testing two experimental COVID-19 booster vaccines in 80 healthy volunteers aged 40-64. One vaccine includes an extra component called 's3' designed to improve the body's immune response. Participants will receive a single dose of either vaccine or a placebo and be …

This study tests an experimental drug called DAS181 in people with weakened immune systems who have a serious lung infection caused by parainfluenza virus. The goal is to see if the drug helps them breathe without extra oxygen and reduces the risk of death. About 274 participants…

This study tests whether baricitinib, a drug used for arthritis, can improve thinking, physical function, and quality of life in people with Long COVID. About 550 adults who had COVID-19 at least 6 months ago will receive either baricitinib or a placebo for 6 months. The main goa…

This study tests whether giving arginine (a natural protein) by IV can improve how cells produce energy in children hospitalized with COVID-19. About 21 kids aged 3 to 21 will receive one of three doses three times a day for up to five days. Researchers will measure changes in mi…

This study looks at whether giving a longer course (10 days instead of 5) or adding another antiviral (remdesivir) to the standard Paxlovid treatment helps immunocompromised people clear COVID-19 faster. About 256 adults with mild or no symptoms will be randomly assigned to diffe…

This phase 2 trial is testing several antiviral drugs—including Paxlovid, molnupiravir, and older drugs like hydroxychloroquine—in 3,800 adults with mild COVID-19. Participants are randomly assigned to receive one of the treatments or no antiviral drug, and researchers measure ho…

This study is testing whether giving a longer course of the antiviral Paxlovid (10 days instead of 5) or combining it with another antiviral (remdesivir) helps immunocompromised people clear COVID-19 faster. About 256 participants with mild to moderate COVID-19 and weakened immun…

This study tests whether giving the antiviral drug remdesivir for 10 days can prevent severe COVID-19 in kidney transplant recipients who have mild or no symptoms. About 15 adults will receive the drug starting just before their transplant. The goal is to see if this approach all…

This study is testing a new, portable breath test called eBAM-CoV to see if it can detect COVID-19 as accurately as the standard nasal swab test (RT-PCR). The breath test is less invasive and gives immediate results. Researchers will compare the two tests in 250 adults who have s…

This early-stage study is testing a new radioactive tracer called 64Cu-FBP8 that lights up blood clots on a special PET-MR scan. Researchers want to see if it can safely and accurately detect clots in people with atrial fibrillation, COVID-19, or cancer. The study involves 165 pa…

This study is testing a breathalyzer kiosk that can detect COVID-19, flu, and RSV by analyzing a person's breath. About 100 adults, both with and without symptoms, will breathe into the device, and the results will be compared to standard nasal swab tests. The goal is to see if t…

This study checks if a new COVID-19 test (Metrix COVID Test) works well when used at home or in clinics. About 1,000 people with COVID symptoms will take the test, and results will be compared to a standard FDA-cleared test. The goal is to see if the new test accurately detects t…

This early-stage study is testing an experimental antibody called MDX2301 to see if it can help prevent severe COVID-19 in healthy adults and those at higher risk. About 80 participants will receive either the antibody or a placebo, given as an injection or infusion. The main goa…

This massive study is tracking over 140,000 people who already take antihistamines (allergy meds) or amantadine (a Parkinson's drug) to see if these drugs protect against COVID-19. Researchers will measure how many get infected, need hospital care, or develop long COVID. The goal…

This study tests whether a pill called mitoquinone can prevent COVID-19 in healthy adults who have had close contact with someone who has COVID-19. About 112 participants will receive either the pill or a placebo. The goal is to see if it stops infection and reduces symptoms.

This study aims to reduce COVID-19 illness and death among people who live or work in prisons. Researchers will test different ways to encourage COVID-19 vaccination in Pennsylvania prisons, involving over 37,000 participants. The goal is to find what works best to increase vacci…

This study tests a home-based exercise program for people who were hospitalized with severe COVID-19. Participants use a smartphone app to guide them through high-intensity interval training and other exercises. The goal is to see if this approach improves walking ability, fitnes…

This study tests whether an 8-week program of supervised physical and cognitive exercises can improve walking, thinking, strength, and quality of life in 374 adults with Long COVID and conditions like high blood pressure or diabetes. Participants are randomly assigned to either t…

This study tests a small device that sends gentle electrical pulses to nerves in the ear to help children ages 11-18 with post-concussion syndrome or long COVID symptoms like pain, nausea, and balance problems. Participants must have had symptoms for at least 3 months. The goal i…

This study is testing whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can improve symptoms like fatigue and brain fog in people with post-COVID syndrome. About 40 adults with long COVID will receive the treatment. The main goal is to see if a la…

This study compares music-backed mindfulness meditation to meditation alone for reducing stress and anxiety in people of African descent. 70 participants with anxiety or depression will join virtual sessions. The goal is to see if adding music makes stress management more effecti…

This study tests a new drug, ratutrelvir, in adults with mild to moderate COVID-19 who are not in the hospital. About 90 participants will take the drug plus standard care to see if it is safe and helps symptoms go away faster. The goal is to find the right dose for future studie…

This study looks at how well seawater nasal sprays work in everyday life for people with nasal and sinus issues like colds, allergies, or after surgery. About 1065 people of all ages, including pregnant women, will use the sprays and report their symptoms. The goal is to see if t…

This study tests whether Astepro, an over-the-counter allergy nasal spray, can help manage early COVID-19 symptoms and reduce viral load. 280 adults with a positive COVID test will use the spray or a placebo for 10 days. Researchers will track symptoms, viral levels, and whether …

This study tests whether a 60-second ultrasound pulse to the brain can improve thinking and memory in people with long COVID brain fog. Forty participants will receive either real or fake (sham) stimulation, and their cognitive performance will be measured before and after. The g…

This study is testing different methods to detect COVID-19 infections and measure immunity. Researchers will use PCR tests to find active infections and antibody tests to see who has been infected before. Up to 2500 volunteers, including staff and their families, will participate…

This study aims to find out how common anti-annexin A2 antibodies are in people hospitalized with COVID-19 and whether these antibodies are linked to lung damage or blood clots. Researchers will test blood samples from 300 adult patients at one hospital. The goal is to see if the…

This study looks at why some people had severe COVID-19 while others had mild symptoms. Researchers will compare the immune system's early response (called interferon) in 134 adults who were sick during the first wave. They also want to see if gut bacteria play a role. The goal i…

This study aims to collect samples and medical information from people of all ages who have or have been exposed to viral infections, including COVID-19 and herpes. Researchers want to understand how viruses affect healthy individuals versus those with weakened immune systems. Pa…

This study is a registry that collects medical information from 1,000 COVID-19 patients treated at San Matteo Hospital in Italy. Researchers will analyze the data to find patterns linked to death during hospitalization. No new drug or treatment is being tested; the goal is to lea…

This study collects blood and nasal secretions from up to 2,000 people with COVID-19 to learn why some get very sick while others recover easily. Researchers will also track long-term symptoms like fatigue and brain fog. No treatments are tested—the goal is to gather data to guid…

This study examines the clinical and socioeconomic factors linked to suicidal behavior in children and adolescents during the COVID-19 pandemic in the Auvergne-Rhône-Alpes region of France. Researchers will collect data from 6,500 participants aged 8 to 17, including medical reco…

This study at Johns Hopkins Hospital is looking at how COVID-19 infection and mRNA vaccines (Pfizer or Moderna) affect pregnant women and their newborns. Researchers will collect blood, placenta, and breast milk samples from 300 participants to study immune responses and pregnanc…

This study is collecting medical information and biological samples from up to 6,000 people with COVID-19. Researchers want to find out which factors predict severe illness, death, or response to treatment. The goal is to better understand the disease and help guide future care.

This study looks at how serious respiratory infections (like flu, COVID-19, and RSV) affect the ability of adults aged 60 and older to live independently. Researchers will follow 1,600 hospitalized seniors across multiple countries to track changes in daily activities such as bat…

This study aims to understand why the protection from vaccines like those for COVID-19 fades over time. Researchers will follow 1,200 healthy adults for one year, collecting blood samples and health updates after they receive a vaccine or booster in their community. The goal is t…

This study aims to understand why some people continue to have symptoms like shortness of breath and fatigue long after a severe COVID-19 infection. Researchers will follow 67 adults for up to 12 months, using scans, blood tests, and other measures to look for clues in the lungs …

This study is a large international registry that will collect health information from 10,000 adults hospitalized with COVID-19. Researchers will track serious outcomes like death, heart failure, and kidney problems. The goal is to learn more about the course of the disease and i…

This study uses surveys and phone interviews to learn how COVID-19 impacts people with cancer. Researchers want to understand the challenges these patients face during the pandemic. About 50 adults with cancer will take part. No treatments or medications are involved.

This study follows 150 NIH staff members for about a year to see how their immune systems respond to flu and COVID-19 vaccines. Participants give monthly blood and nasal samples to measure antibodies in both the body and the nose. The goal is to understand how long immunity lasts…

This study looks at how common COVID-19 is among healthcare workers by testing for antibodies in their blood. It also checks their mental and emotional health during the pandemic. About 1,000 workers from NewYork-Presbyterian will take part. The goal is to learn how to better pro…

This study aims to collect blood, nose, and saliva samples from up to 20,000 people aged 3 and older who have or may have a respiratory virus infection like flu or COVID-19. The samples will be stored and used in future research to better understand these viruses and how the immu…

This study follows 1,350 people in Hong Kong households to see how their protection against COVID-19 changes over time. Researchers will measure antibodies from both vaccination and past infection. The goal is to understand how household immunity evolves and how it affects the ri…

This study looks at how well the flu vaccine works in people who have had COVID-19, including those with long-term symptoms like fatigue or diabetes. Researchers will compare immune responses between 230 adults and children (ages 9-64) who had COVID-19 and those who did not. The …

This study is testing whether giving the COVID-19 booster and flu vaccine at the same time is as good as giving them a month apart for people with weakened immune systems. It also compares getting a COVID-19 booster every 3 months versus every 6 months. The trial involves 660 adu…

This study aims to understand how changes in gut bacteria (dysbiosis) affect the immune system and gut health in people with long COVID. Researchers will collect stool and blood samples from 400 adults—half with long COVID symptoms and half without. The goal is to find links betw…

This study trains community health workers to create and share personal stories and infographics on social media to promote flu, COVID-19, and other respiratory virus vaccines. Researchers will survey the health workers' social media followers to see if the messages change their …

This study looks at 320 adults who are about to start strong immune-suppressing therapy and have already had at least two COVID-19 shots. Researchers want to find out if giving a COVID-19 booster right before starting therapy or waiting six months provides better protection. Part…

This study tests whether a virtual, community-based program combining music and mindfulness can help People of African Descent manage stress, anxiety, and depression during COVID-19. Researchers will measure brain activity and feelings of social connection in 48 participants as t…

This study uses an online survey to understand how medication use, self-medication, and other factors affect healthy aging in adults 18 and older. Researchers will look at drug interactions, polypharmacy (taking five or more medications), and genetic factors in a subgroup. The go…

This study uses cardiac MRI and other tests to examine heart and lung function in 510 COVID-19 survivors who had symptoms like shortness of breath or cough. The goal is to find out why some people have lasting cardiopulmonary problems after COVID-19. Participants will undergo ima…

This study trains medical students at the University of Sherbrooke to collect health data from 6,000 people in Quebec. Participants answer questions about lifestyle, access to health services, and other public health topics. The goal is to better understand health trends and help…

This study will follow 30 adults who have received vaccines or antibody treatments for COVID-19 or monkeypox. Researchers will take blood and optional nasal swabs over time to measure how well the body's antibodies neutralize these viruses. The goal is to better understand how lo…

This study follows 10,000 pregnant women in Nagpur, India, from early pregnancy through 42 days after birth. Researchers want to learn if catching flu or COVID-19 raises the risk of problems like preterm labor or severe pre-eclampsia. The goal is to provide clear evidence to help…

This study follows 345 adults to learn how COVID-19 may cause lasting damage to the lungs, heart, and kidneys. Researchers will compare people who had COVID-19 with those who did not, using blood tests, breathing tests, and heart scans. The goal is to find early warning signs and…

This study follows about 800 people who have recovered from COVID-19 to learn how long the virus can stay in different parts of the body, such as the nose, stool, semen, and breast milk. Researchers will also track how the immune system responds and look for any long-term health …

This study aims to understand how common respiratory viruses like COVID-19, flu, and RSV spread in communities. Researchers will track up to 25,000 people of all ages using at-home test kits and symptom surveys. The goal is to better predict outbreaks and improve public health re…

This study from Indiana University looks at how the COVID-19 pandemic may have changed people's physical activity, sleep, diet, blood pressure, and mental stress. Researchers will track 100 adults aged 18-75 using wearable devices, fitness tests, blood samples, and blood pressure…

This study looks at how pregnant and non-pregnant people recover after being in the intensive care unit (ICU) for severe COVID-19. Researchers will check for problems with movement, thinking, and mental health 3 to 6 months after leaving the ICU. The goal is to understand the lon…

This study follows 2,300 adults who had COVID-19 to learn why some develop long-term symptoms like fatigue, brain fog, or organ damage. Researchers will review medical records and track participants over time. The goal is to find patterns and predictors of post-COVID condition, w…

This study follows 1800 healthcare workers from eight countries for up to 24 months to see how their immune systems respond to COVID-19 vaccines and infections. Researchers will collect blood samples and health data to understand how different viral variants affect immunity. The …

This study tests whether a clear plastic box placed over a patient's head during CPR can reduce the spread of viruses like COVID-19 to healthcare workers. Researchers will simulate cardiac arrest scenarios with 240 participants, measuring how well the box works during chest compr…