COVID-19

This study is testing updated versions of Moderna's COVID-19 vaccine designed to match current virus variants. It will enroll about 832 people aged 65 and older, or those 12-64 with health conditions that put them at high risk for severe COVID-19. The main goals are to see how we…

This early-stage study is testing the safety and immune response of a new COVID-19 booster vaccine called Boost-2867. It will be given to 140 healthy adults who have already been vaccinated, either as a shot in the arm or as a nasal spray. Researchers want to find the safest and …

This study is testing updated versions of the Pfizer-BioNTech COVID-19 vaccine in healthy children from 6 months to 12 years old. It aims to check the safety, side effects, and how well the body's immune system responds to these new shots. The trial includes children who have nev…

This is an early-stage study testing a new COVID-19 vaccine given as a nasal spray. Researchers want to see if two slightly different versions of the vaccine are safe and can trigger a good immune response in healthy adults. Participants will get two doses, one month apart, and t…

This study is testing two new COVID-19 booster vaccines in healthy adults aged 40-64. Researchers want to see if the vaccines are safe and if a special component called 's3' helps create stronger, broader, and longer-lasting immune protection against COVID-19 variants. Participan…

This study is testing a new COVID-19 booster vaccine given as a nasal spray. It will compare the spray's safety and the immune response it creates to a standard mRNA vaccine shot. The trial will enroll about 200 adults who have already been vaccinated against COVID-19 at least 6 …

This study aims to see how safe and effective an updated COVID-19 vaccine is for healthy adults between 50 and 64 years old. About 25,500 participants will be randomly assigned to receive either the new vaccine or a placebo (a shot with no active ingredient). Researchers will com…

This study is testing whether a new drug called ratutrelvir, when given alongside standard COVID-19 treatment, is safe and helps people recover faster from mild to moderate COVID-19. The trial will enroll 90 adults who have had COVID-19 symptoms for less than 5 days and don't req…

This study is testing if a medication called baricitinib can help people suffering from Long COVID. It will involve 550 adults who have had symptoms like brain fog, fatigue, and shortness of breath for at least six months after a COVID-19 infection. Participants will be randomly …

This study is testing whether a 10-day course of the antiviral drug remdesivir can safely prevent kidney transplant patients with mild or no COVID-19 symptoms from developing severe illness. The goal is to allow transplants to proceed without delay for these patients, who are at …

This study is testing a new inhaled nasal medication called Optate for people with early COVID-19 symptoms. Researchers want to see if this treatment can reduce the amount of virus in the nose and lungs and help people feel better faster. The study involves 40 participants who ha…

This study aims to find the best way to give COVID-19 booster shots and seasonal flu vaccines to adults with weakened immune systems. Researchers want to know if getting both shots on the same day works as well as getting them a month apart, and if getting COVID boosters every 3 …

This study aims to find better COVID-19 treatments for people with weakened immune systems. Researchers are testing whether combining two antiviral drugs works better than using one alone, and whether extending treatment from 5 to 10 days helps clear the virus faster. The trial w…

This study aims to see if people who already take antihistamines (common allergy drugs) or amantadine (a Parkinson's drug) have milder COVID-19. Researchers will track over 140,000 people to compare rates of hospitalization, survival, and long-term symptoms between those on these…

This study is testing whether Astepro, a common allergy nasal spray, can help control early COVID-19 infection. Researchers will give the spray or a placebo to 280 vaccinated adults who just tested positive but have only mild or no symptoms. They will measure if the spray reduces…

This study is testing if using two antiviral drugs together works better than one alone, and if taking the main drug for 10 days is better than 5 days, for people with weakened immune systems who get COVID-19. It aims to help these high-risk patients clear the virus faster and mo…

This trial is testing several different antiviral drugs to see which ones work best at clearing the COVID-19 virus from people's bodies. It will enroll 3,800 healthy adults who have just developed mild COVID-19 symptoms. The study compares how quickly different treatments reduce …

This study aims to find the best timing for a COVID-19 booster shot for people who need to start treatments that weaken their immune system, such as for cancer or autoimmune diseases. Researchers will compare giving the booster right before treatment starts versus waiting six mon…

This study is testing a new at-home COVID-19 test kit called the Metrix COVID Test to see how accurately it detects the virus compared to standard lab tests. Researchers will enroll 1,000 people aged 2 and older who currently have symptoms like fever or cough. Participants will u…

This study is testing a new type of breathalyzer kiosk designed to detect viruses like COVID-19, flu, and RSV quickly and without a nasal swab. Researchers will enroll 100 adults, with and without symptoms, to see how well the device's breath analysis matches standard lab tests. …

This early-stage study is testing a new imaging tracer called 64Cu-FBP8 to see if it can safely and accurately detect blood clots throughout the body using a PET-MR scan. Researchers are enrolling 165 healthy volunteers and patients with conditions like atrial fibrillation, COVID…

This study aims to find the best ways to increase COVID-19 and flu vaccination rates in prisons. Researchers are working directly with prison communities to test different strategies across Pennsylvania's prison system. The goal is to reduce illness and death from COVID-19 among …

This study is testing whether screening people for social needs—like food or housing insecurity—and connecting them to community services can help prevent COVID-19 transmission and improve overall health. It will enroll 1,500 adults from emergency departments and testing sites wh…

This is an early-stage study testing a new drug called MDX2301 to see if it can help prevent severe COVID-19. Researchers will give single and repeat injections to 80 healthy adults and adults with conditions that put them at higher risk for severe COVID-19. The main goal is to c…

This large study aims to see how well an updated COVID-19 vaccine prevents severe illness in healthy adults aged 50-64. About 285,000 participants without known risk factors will be randomly assigned to receive either the vaccine or no vaccine. Researchers will track hospital vis…

This study aims to find the best way to encourage more Latino adults in Maryland to get vaccinated against COVID-19. Researchers will compare two methods: training vaccinated people to have supportive conversations with their friends and family versus simply providing vaccine inf…

This small pilot study is exploring whether hyperbaric oxygen therapy (HBOT) can help people suffering from Long COVID. Participants with persistent symptoms like fatigue and 'brain fog' will spend time in a pressurized chamber breathing pure oxygen to see if it improves their co…

This Yale University study is testing whether virtual, community-based programs that combine music and mindfulness can help people of African descent better manage stress, anxiety, and depression. The research focuses on creating culturally relevant support, as these groups are o…

This study is testing whether a gentle, non-invasive ultrasound treatment aimed at a specific brain area can improve thinking and memory problems in people with long COVID 'brain fog'. Researchers in Beijing will give 40 participants either the real ultrasound treatment or a sham…

This study is testing whether eating more fermented foods like yogurt, kimchi, and sauerkraut can help people recover mentally and emotionally after a life-threatening illness like severe COVID-19. Researchers want to see if this diet improves gut health, reduces inflammation, an…

This study is checking how well four different seawater-based nasal sprays work in everyday life to relieve stuffy, runny, and blocked noses. It will involve over 1,000 people, including babies, children, adults, and pregnant women, who suffer from colds, allergies, or chronic si…

This study is testing whether a small device placed on the outer ear can help reduce symptoms in children with post-concussion syndrome or long-lasting symptoms after COVID-19. The device uses gentle electrical stimulation and is worn for five days at a time. Researchers will mea…

This study is testing whether a virtual, community-based program combining music with mindfulness exercises can help reduce stress, anxiety, and depression. It focuses on People of African Descent in America, a group disproportionately affected by stress. Researchers will compare…

This study aims to understand why many COVID-19 survivors experience lasting symptoms like fatigue and shortness of breath. Researchers will use detailed heart and lung scans (MRI) on over 500 survivors to look for hidden damage. The goal is to see if these scans can help predict…

This study aims to understand how common long-term symptoms (often called Long COVID) are after a person recovers from COVID-19. Researchers will observe 2,300 adults who had COVID-19 to track their health over time. The goal is to identify who is most at risk for these lasting s…

This study aims to understand how infections with COVID-19, influenza, and other respiratory viruses during pregnancy affect the health of mothers and their babies. Researchers will follow 10,000 pregnant women in India from early pregnancy through the weeks after birth, tracking…

This study aims to understand how long immunity against COVID-19 lasts in healthcare workers who have been vaccinated or previously infected. Researchers will follow 1,800 participants across eight countries, collecting blood samples every few months to measure immune responses. …

This study aims to understand how COVID-19 affects long-term health by measuring fitness, blood pressure, sleep, and stress. Researchers will enroll 100 adults for two lab visits involving questionnaires, fitness tests, and health monitoring. The goal is to learn how past COVID-1…

This study aims to collect samples from people with respiratory virus infections like the flu or COVID-19. Researchers will store these samples in a repository to be used in future research. The goal is to learn more about how these viruses work and how our bodies fight them, whi…

This study aims to understand why the immune protection from vaccines, like those for COVID-19, decreases over time. Researchers will follow healthy adults who are scheduled to get a new vaccine or a booster shot. Participants will provide blood samples over one year so scientist…

This study aims to understand how COVID-19 increases the risk of long-term lung, heart, and kidney problems, often called Long COVID. Researchers will observe 345 adults, comparing those who had COVID-19 with those who did not, to track organ health over time. The goal is to gath…

This study aims to understand how long protective antibodies last in people's blood and noses after they receive vaccines or antibody treatments for COVID-19 or Monkeypox. Researchers will follow 30 adults for up to 5 years, collecting samples to measure antibody levels over time…

This study aims to understand how protection against COVID-19 changes within families over time. Researchers will follow 900 households in Hong Kong for 12-18 months, checking blood for antibodies from vaccines and past infections. The goal is to learn how immunity levels in a ho…

This study aims to directly compare how well two different FDA-approved COVID-19 vaccines (Novavax and Pfizer) trigger immune responses and what side effects they cause. It will enroll 54 adults aged 18-79 who have certain health conditions that put them at higher risk for severe…

This study follows 800 people who recovered from COVID-19 for two years to understand how long the virus can stay in different parts of the body and what long-term health problems might develop. Researchers collect blood, saliva, stool, and other samples up to 12 times to track v…

This study aims to understand how COVID-19 changes gut bacteria in people with long COVID symptoms. Researchers will collect stool and blood samples from 400 people with and without long COVID to identify bacterial differences. The goal is to learn how these changes might contrib…

This study aims to understand how the body's immune system responds and changes over time after receiving the seasonal flu vaccine and/or a COVID-19 vaccine. Researchers will follow about 150 adult NIH staff members for roughly a year, collecting monthly blood and nasal samples. …

This study aims to understand how viruses like COVID-19 and herpes change and spread by collecting samples from people. Researchers are enrolling 1,000 participants, including both healthy individuals and those with weakened immune systems, to provide samples like blood and swabs…

This large study aims to understand how often and how respiratory viruses like COVID-19, flu, and RSV spread in communities and households. It will enroll up to 25,000 people, including families, to track infections through regular symptom checks and at-home test kits. The goal i…

This is an online survey aiming to understand how multiple medications, self-treatment, and lifestyle factors affect health risks, especially for people wanting to live longer, healthier lives. Researchers will invite at least 2,000 adults to complete a confidential online questi…

This study examines whether clear plastic 'aerosol boxes' protect healthcare workers from virus particles during CPR on COVID-19 patients. Researchers will simulate emergency scenarios with 240 healthcare professionals across North America to measure particle spread and CPR quali…

This study aims to understand the long-term recovery challenges faced by patients who survived severe COVID-19 requiring intensive care. Researchers are comparing about 13 pregnant patients with about 27 non-pregnant patients to see if pregnancy affects recovery in areas like phy…

This study is testing a new way to share trustworthy health information online. Researchers are training community health workers in seven high-risk neighborhoods to post personal stories about flu and COVID-19 protection on their social media. The goal is to see if these persona…