Could a pill replace the COVID-19 booster shot?

NCT ID NCT06672055

Ongoing ⭐️ VACCINE ⭐️ Sponsor: Vaxart Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an experimental oral COVID-19 vaccine tablet (VXA-CoV2-3.3) against approved mRNA booster shots in about 5,500 adults who have already been vaccinated. The goal is to see if the tablet can prevent symptomatic COVID-19 as well as or better than the injectable vaccine. Participants will be randomly assigned to receive either the oral tablet or an mRNA booster, and researchers will track infections and side effects for up to a year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: oral SARS-CoV-2 vaccine tablet (VXA-CoV2-3.3, KP.2 strain)
What this could lead to: If successful, this could offer a needle-free, easier-to-store COVID-19 booster option that may be more acceptable to people who avoid injections.
What could go wrong: This is a mid-stage trial, so the oral vaccine may not prove as effective as mRNA shots. Side effects or immune response differences could limit its use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

COVID-19 prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID-19 SARS-COV2

Contacts and locations

Locations

AMR - El Dorado - Heartland Research Associates

El Dorado, Kansas, 67042, United States
AMR - Fort Myers - Clinical Physiology Associates

Fort Myers, Florida, 33912, United States
AMR - Lexington (Central Kentucky Research Associates)

Lexington, Kentucky, 40509, United States
AMR - Miami (Clinical Research of South Florida)

Coral Gables, Florida, 33134, United States
AMR - New Orleans - Center for Clinical Research

New Orleans, Louisiana, 70119, United States
AMR - Newton (Heartland Research Associates)

Newton, Kansas, 67114, United States
AMR - Norfolk (Clinical Research Associates of Tidewater)

Norfolk, Virginia, 23502, United States
AMR - Wichita East - Heartland Research Associates

Wichita, Kansas, 67207, United States
AMR - Wichita West - Heartland Research Associates

Wichita, Kansas, 67205, United States
AXCES Research & Health - Santa Fe

Santa Fe, New Mexico, 87505, United States
Accel Research Sites (ARS) - St. Petersburg - Largo

Largo, Florida, 33777, United States
Accel Research Sites - Lakeland

Lakeland, Florida, 33803, United States
Accel Research Sites - Maitland

Maitland, Florida, 32751, United States
Accellacare - Charleston

Mt. Pleasant, South Carolina, 29464, United States
Accellacare - Duly Health and Care

Lombard, Illinois, 60148, United States
Accellacare - Hickory

Hickory, North Carolina, 28601, United States
Accellacare - McFarland Clinic

Ames, Iowa, 50010, United States
Accellacare - PMG Research of Bristol

Bristol, Tennessee, 37620, United States
Accellacare - Piedmont Healthcare

Statesville, North Carolina, 28625, United States
Accellacare - Raleigh

Raleigh, North Carolina, 27609, United States
Accellacare - Rocky Mount

Rocky Mount, North Carolina, 27804, United States
Accellacare - Salisbury

Salisbury, North Carolina, 28144, United States
Accellacare - Tradd Court

Wilmington, North Carolina, 28401, United States
Accellacare - Winston-Salem

Winston-Salem, North Carolina, 27103, United States
Accellacare of Knoxville

Knoxville, Tennessee, 37912, United States
Alliance for Multispecialty Research (AMR) - Corporate

Knoxville, Tennessee, 37909, United States
Altasciences Los Angeles (Formerly WCCT Global)

Cypress, California, 90630, United States
Ark Clinical Research - Fountain Valley, CA

Fountain Valley, California, 92708, United States
Ark Clinical Research - Long Beach, CA

Long Beach, California, 90815, United States
Atlas Clinical Research - Rochester Clinical Research

Rochester, New York, 14609, United States
Atlas Clinical Research - Suburban Research Associates - Media Office

Media, Pennsylvania, 19063, United States
Atlas Clinical Research - Suncoast Clinical Research - Pasco County

New Port Richey, Florida, 34652, United States
Atrium Health Wake Forest Baptist - Comprehensive Cancer Center

Winston-Salem, North Carolina, 27157, United States
Avacare (CCT) - Advanced Primary and Geriatric Care

Rockville, Maryland, 20850, United States
Avacare (CCT) - Clay Platte Family Medicine Clinic

Kansas City, Missouri, 64151, United States
Avacare (CCT) - Fiel Family & Sports Medicine

Tempe, Arizona, 85283, United States
Avacare (CCT) - Hatboro Medical Associates

Hatboro, Pennsylvania, 19040, United States
Avacare (CCT) - Lifeline Primary Care

Lilburn, Georgia, 30047, United States
Avacare (CCT) - Ogden Clinic - Grand View

Roy, Utah, 84067, United States
Avacare (CCT) - Olympus Family Medicine

Salt Lake City, Utah, 84117, United States
Avacare (CCT) - Skyline Medical Center

Elkhorn, Nebraska, 68022, United States
Avacare - Benchmark Research - Metairie

Metairie, Louisiana, 70006, United States
Avacare - Benchmark Research - New Orleans-North Shore

Covington, Louisiana, 70433, United States
Avacare - Benchmark Research - SOCAL-Colton

Colton, California, 92324, United States
Avacare - Benchmark Research - Sacramento

Sacramento, California, 95864, United States
Avacare - Benchmark Research Fort Worth

Fort Worth, Texas, 76135, United States
Avacare - Critical Care, Pulmonary and Sleep Associates

Lakewood, Colorado, 80228, United States
Avacare - Lenzmeier Family Medicine

Glendale, Arizona, 85308, United States
Baptist Health Center for Clinical Research - Little Rock

Little Rock, Arkansas, 72205, United States
Be Well Clinical Studies - Nebraska

Lincoln, Nebraska, 68516, United States
Biscayne Clinical Research

North Miami Beach, Florida, 33169, United States
Boca Raton Clinical Research (BRCR) Global - Weston

Plantation, Florida, 33322, United States
Boca Raton Clinical Research (BRCR) Global USA - New Orleans

Gretna, Louisiana, 70053, United States
CTI Clinical Research Center

Cincinnati, Ohio, 45212, United States
Cary Medical Group

Cary, North Carolina, 27518, United States
Cedar Health Research - Arlington/Euless

Euless, Texas, 76040, United States
Centricity Research (IACT Health) - Suffolk Primary Care

Suffolk, Virginia, 23435, United States
Chase Medical Research

Waterbury, Connecticut, 06708, United States
Coastal Clinical Research

Mobile, Alabama, 36608, United States
Core Clinical Trials - Central Alabama Research LLC

Birmingham, Alabama, 35209-8401, United States
DM Clinical Research - CyFair Clinical Research Center

Houston, Texas, 77065, United States
DM Clinical Research - Jersey City

Jersey City, New Jersey, 07306, United States
DM Clinical Research - Tomball - Multiple Specialties

Tomball, Texas, 77375, United States
Desert Clinical Research

Mesa, Arizona, 85213, United States
ENCORE - Nature Coast Clinical Research Inverness

Inverness, Florida, 34452, United States
ENCORE - St. Johns Center for Clinical Research

Saint Augustine, Florida, 32086, United States
ENCORE - Westside Center for Clinical Research

Jacksonville, Florida, 32205, United States
Elite Research Network (ERN) - Legacy Clinical Trials

Colorado Springs, Colorado, 80909, United States
Elligo Health Research (BTC/ClinEdge) - Core Healthcare Group

Cerritos, California, 90703, United States
EmVenio Research - Fort Worth, TX

Fort Worth, Texas, 76134, United States
Fleming Island Center For Clinical Research

Fleming Island, Florida, 32003, United States
Foothills Research Center

Phoenix, Arizona, 85044, United States
Headlands Research - JEM Research - Lake Worth

Lake Worth, Florida, 33462, United States
Health Research of Hampton Roads

Newport News, Virginia, 23606, United States
IMA Clinical Research - Albany, Suite 202

Albany, New York, 12205, United States
IMA Clinical Research - Austin

Austin, Texas, 78745, United States
IMA Clinical Research - Chicago

Chicago, Illinois, 60602, United States
IMA Clinical Research - Manhattan

New York, New York, 10036, United States
IMA Clinical Research - St. Petersburg

St. Petersburg, Florida, 33704, United States
Jacksonville Center for Clinical Research

Jacksonville, Florida, 32216, United States
Javara Research - Mankato Clinic

Mankato, Minnesota, 56001, United States
Javara Research - Privia Medical Group Georgia

Fayetteville, Georgia, 30214, United States
Javara Research - Privia Medical Group Mid-Atlantic - Annapolis

Annapolis, Maryland, 21401, United States
Johnson County Clin-Trials

Lenexa, Kansas, 66219, United States
K2 Medical Research - Maitland

Maitland, Florida, 32751, United States
K2 Medical Research - South Orlando

Orlando, Florida, 32806, United States
Northern California Research

Sacramento, California, 95821, United States
Orion Clinical Research

Austin, Texas, 78759, United States
PanAmerican Clinical Research - Brownsville, Levee Street

Brownsville, Texas, 78520, United States
Paradigm Clinical Research - Wheat Ridge

Wheat Ridge, Colorado, 80033, United States
Pharmaron

Baltimore, Maryland, 21201, United States
Pinnacle Research Group

Anniston, Alabama, 36207, United States
Privia Health - SouthCoast Health

Fayetteville, Georgia, 30214, United States
SRA Trials LLC - Miami Clinical Trials at Suncoast Research Associates

Miami, Florida, 33173, United States
South Ogden Family Medicine

South Ogden, Utah, 84405, United States
Stamford Therapeutics Consortium

Stamford, Connecticut, 06905, United States
Tekton Research - Austin

Austin, Texas, 78745, United States
Tekton Research - Beaumont

Beaumont, Texas, 77706, United States
Tekton Research - Colorado - Longmont

Longmont, Colorado, 80501, United States
Tekton Research - Delaware Pointe

Tulsa, Oklahoma, 74137, United States
Tekton Research - Fort Collins

Fort Collins, Colorado, 80528, United States
Tekton Research - Fredericksburg Road

San Antonio, Texas, 78229, United States
Tekton Research - Oklahoma - Magnolia Court

Moore, Oklahoma, 73160, United States
Tekton Research - Oklahoma - Primary Health Partners

Yukon, Oklahoma, 73099, United States
Trial Management Associates - Myrtle Beach

Myrtle Beach, South Carolina, 29572, United States
Universal Axon Clinical Research

Doral, Florida, 33166, United States
Velocity (Meridian) Clinical Research - Baton Rouge

Baton Rouge, Louisiana, 70809, United States
Velocity (Meridian) Clinical Research - Grand Island

Grand Island, Nebraska, 68803, United States
Velocity (Meridian) Clinical Research - Omaha

Omaha, Nebraska, 68134, United States
Velocity (Meridian) Clinical Research - Rockville

Rockville, Maryland, 20854, United States
Velocity (Meridian) Clinical Research - Sioux City

Sioux City, Iowa, 51106, United States
Velocity Clinical Research (National Research Institute) - Panorama City

Los Angeles, California, 90057, United States
Velocity Clinical Research - Abilene

Abilene, Texas, 79606, United States
Velocity Clinical Research - Alburquerque

Albuquerque, New Mexico, 87107, United States
Velocity Clinical Research - Anderson

Anderson, South Carolina, 29621, United States
Velocity Clinical Research - Austin

Austin, Texas, 78759, United States
Velocity Clinical Research - Boise (Meridian)

Meridian, Idaho, 83642, United States
Velocity Clinical Research - Charleston

Charleston, South Carolina, 29414, United States
Velocity Clinical Research - Chula Vista (eStudySite - Chula Vista)

Chula Vista, California, 91911, United States
Velocity Clinical Research - Cincinnati (New Horizons Clinical Research - Blue Ash)

Cincinnati, Ohio, 45242, United States
Velocity Clinical Research - Cleveland (Rapid Medical Research)

Beachwood, Ohio, 44122, United States
Velocity Clinical Research - Columbia (VitaLink)

Columbia, South Carolina, 29204, United States
Velocity Clinical Research - Durham

Durham, North Carolina, 27701, United States
Velocity Clinical Research - Gardena

Santa Ana, California, 92704, United States
Velocity Clinical Research - Grants Pass

Grants Pass, Oregon, 97527, United States
Velocity Clinical Research - Hallandale Beach (MD Clinical)

Hallandale, Florida, 33009, United States
Velocity Clinical Research - MedPharmics - Covington

Covington, Louisiana, 70433, United States
Velocity Clinical Research - MedPharmics - Gulfport

Gulfport, Mississippi, 39503, United States
Velocity Clinical Research - MedPharmics - Lafayette

Lafayette, Louisiana, 70508, United States
Velocity Clinical Research - MedPharmics - Phoenix

Phoenix, Arizona, 85020, United States
Velocity Clinical Research - Medford

Spokane, Washington, 99204, United States
Velocity Clinical Research - New Smyrna Beach

Edgewater, Florida, 32132, United States
Velocity Clinical Research - Providence (East Greenwich)

East Greenwich, Rhode Island, 02818, United States
Velocity Clinical Research - San Diego (eStudySite - La Mesa)

La Mesa, California, 91942, United States
Velocity Clinical Research - Savannah

Savannah, Georgia, 31406, United States
Velocity Clinical Research - Spokane

Spokane, Washington, 99204, United States
Velocity Clinical Research - Syracuse

East Syracuse, New York, 13057, United States
Velocity Clinical Research - Union (Vitalink)

Union, South Carolina, 29379, United States
Velocity Clinical Research - Valparaiso (Buynak Clinical Research)

Valparaiso, Indiana, 46383, United States
Velocity Clinical Research - Waco (formerly: Impact Research Institute)

Waco, Texas, 76710, United States
Velocity Clinical Research - Washington DC

Washington D.C., District of Columbia, 20016, United States
hyperCORE - ActivMed Practices and Research - Portsmouth

Portsmouth, New Hampshire, 03801, United States
hyperCORE - Centricity Research (IACT Health) - Rincon

Rincon, Georgia, 31326, United States
hyperCORE - Centricity Research Columbus

Columbus, Georgia, 31904, United States
hyperCORE International - Coastal Carolina Research Center

North Charleston, South Carolina, 29405, United States

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