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COVID-19 in pregnancy: new study probes placenta for clues

NCT ID NCT04585945

Knowledge-focused Sponsor: Prisma Health-Upstate Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at placentas from 68 women who had COVID-19 during pregnancy to see if the virus changes the placenta's structure or gene activity. Researchers also checked umbilical cord blood for signs of inflammation. The goal is to better understand how the infection might affect the baby's health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors understand how COVID-19 affects pregnancy and guide care for infected mothers.
What could go wrong
This is a small, completed observational study. It only looks at placentas after birth, so it cannot prove cause and effect or directly improve treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

68 people

The number who actually took part.

Started

Aug 2020

Finished

Feb 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The target population for the present study includes all women delivering at Greenville Memorial Hospital. The opportunity for enrollment may be extended to women that deliver at Greenville Memorial even if they conducted prenatal care outside of the Prisma OB/GYN Center if they meet the eligibility. A total of 40 patients will be recruited for analysis. Additionally, 60 samples will be recruited from women delivering at NorthShore Health System who test positive for COVID-19 during pregnancy.

Ages

18 years and older

Sex

Female participants only

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. COVID-19 infection during pregnancy, including at time of delivery 2. Age \>=18 years 3. ≥13 6/7 weeks' GA Exclusion Criteria: 1. Known major fetal chromosomal abnormality 2. Other major infection during pregnancy (specifically influenza A or B, cytomegalovirus, toxoplasma, rubella, syphilis, HIV)

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Conditions

The condition(s) this trial relates to.

COVID-19

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID -19 SARS-CoV-2 infection

Contacts and locations

Locations

  • Prisma Health Upstate

    Greenville, South Carolina, 29605, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.