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The household maze: how does COVID-19 move between family members?

NCT ID NCT05467917

Knowledge-focused Sponsor: Columbia University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 11, 2026 · Last updated Sep 11, 2026

Summary

Researchers at Columbia University are studying how SARS-CoV-2, the virus that causes COVID-19, spreads among people living in the same home. They enroll households with at least one person who tests positive or was exposed to the virus, including children and health care workers. Participants collect nasal swabs at home every few days and give blood samples. The goal is to measure how many household members get infected and what factors, such as age, symptoms, or behavior, predict who gets sick.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If the study identifies which household members are most likely to spread the virus, it could shape testing and isolation advice for families and health care workers.
What could go wrong
This is an observational study, so it cannot prove cause and effect. Households may drop out or follow safety measures that hide true transmission patterns.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 374 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2021

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Pediatric patients, New York Presbyterian health workers, and any individual who has been exposed to SARS-CoV-2 cases and their household contacts residing in New York City.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Index is a positive child AND at least one household member is negative OR * Index is a positive symptomatic / asymptomatic New York Presbyterian Hospital (NYP) and affiliates worker or any individual AND at least one household member is negative OR * Either Index case is negative, exposed to a confirmed positive SARS-CoV-2 case, AND at least one household members is negative Exclusion Criteria: * Index case is positive and all household members are positive

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Conditions

The condition(s) this trial relates to.

COVID-19

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID -19 Households SARS-CoV-2 infection

Contacts and locations

Locations

  • Columbia University Irving Medical Center

    New York, New York, 10031, United States

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