New mRNA boosters aim to outsmart omicron variants
NCT ID NCT05472038
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested several updated mRNA COVID-19 booster vaccines in over 1,400 healthy adults who had already received prior COVID-19 vaccines. The goal was to see if these new boosters are safe and can improve the immune response against newer Omicron variants. Participants received a single shot and were monitored for about six months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
mRNA vaccine (updated COVID-19 booster)
What this could lead to
If successful, this could lead to better protection against new COVID-19 variants with updated booster shots.
What could go wrong
This is a completed early-to-mid stage trial, so results may not confirm long-term protection. Side effects like injection site pain and fatigue are common.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Accellacare - Charlotte
Charlotte, North Carolina, 28211, United States
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Accellacare - Wilmington
Wilmington, North Carolina, 28401, United States
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Acevedo Clinical Research Associates
Miami, Florida, 33142, United States
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Anaheim Clinical Trials, LLC
Anaheim, California, 92801, United States
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Bayview Research Group, LLC
Valley Village, California, 91607, United States
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Benchmark Research
Austin, Texas, 78705, United States
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California Research Foundation
San Diego, California, 92123, United States
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Centricity Research Columbus Ohio Multispecialty
Columbus, Ohio, 43213, United States
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Clinical Neuroscience Solutions Inc.
Memphis, Tennessee, 38119, United States
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Clinical Neuroscience Solutions, Inc. dba CNS Healthcare
Jacksonville, Florida, 32256, United States
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Clinical Research Atlanta
Stockbridge, Georgia, 30281, United States
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Clinical Research Consulting
Milford, Connecticut, 06460, United States
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Clinical Research Professionals
Chesterfield, Missouri, 63005, United States
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DM Clinical Research - Bellaire
Houston, Texas, 77081, United States
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DM Clinical Research - MDC
Tomball, Texas, 77375, United States
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Diablo Clinical Research, Inc.
Walnut Creek, California, 94598, United States
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East-West Medical Research Institute
Honolulu, Hawaii, 96814, United States
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IMA Clinical Research San Antonio
San Antonio, Texas, 78229, United States
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J. Lewis Research, Inc. / Foothill Family Clinic
Salt Lake City, Utah, 84109, United States
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J. Lewis Research, Inc. / Foothill Family Clinic South
Salt Lake City, Utah, 84121, United States
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Kaiser Permanente Northwest Center for Health Research
Portland, Oregon, 97227, United States
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Kentucky Pediatric/ Adult Research
Bardstown, Kentucky, 40004, United States
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PharmQuest Life Sciences, LLC
Greensboro, North Carolina, 27408, United States
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Research Centers of America ( Hollywood )
Hollywood, Florida, 33024, United States
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Rochester Clinical Research, LLC
Rochester, New York, 14609, United States
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Senders Pediatrics
Cleveland, Ohio, 44121, United States
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South Jersey Infectious Disease
Somers Point, New Jersey, 08244, United States
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Sundance Clinical Research
St Louis, Missouri, 63141, United States
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Tekton Research, LLC.
Austin, Texas, 78745, United States
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Velocity Clinical Research, Omaha
Omaha, Nebraska, 68134, United States
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Virginia Research Center
Midlothian, Virginia, 23114, United States