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New COVID booster shows promise in Mix-and-Match trial

NCT ID NCT05142553

Completed ⭐️ VACCINE ⭐️ Sponsor: Hipra Scientific, S.L.U Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new booster vaccine called PHH-1V in 887 adults who had already received two doses of the Pfizer COVID-19 vaccine. The goal was to see if the new booster was as safe and effective as a third Pfizer dose. The trial also looked at the effects of a fourth dose of PHH-1V. Participants were monitored for side effects and immune response over a year.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

COVID-19 prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID-19 SARS-COV-2 ACUTE RESPIRATORY DISEASE

Contacts and locations

Locations

  • Hospital Clinic de Barcelona

    Barcelona, Barcelona, 17170, Spain

  • Hospital Clínico de Valencia

    Valencia, Valencia, 46010, Spain

  • Hospital Germans Trias I Pujol

    Badalona, BARCELONA, 08916, Spain

  • Hospital Gregorio Marañón

    Madrid, Madrid, 28007, Spain

  • Hospital Principe de Asturias

    Meco, Madrid, 28805, Spain

  • Hospital Regional Universitario de Málaga

    Málaga, Málaga, 29010, Spain

  • Hospital Universitari Dr. Josep Trueta

    Girona, Girona, 17007, Spain

  • Hospital Universitario La Paz

    Madrid, Madrid, 28046, Spain

  • Hospital Vall Hebron

    Barcelona, BARCELONA, 08035, Spain

  • Hospital de Cruces

    Barakaldo, VIZCAYA, 48903, Spain

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