Can lower drug doses make stem cell transplants safer for seniors?
NCT ID NCT05849207
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study is for people aged 65 and older with blood cancers who are getting a stem cell transplant. Researchers want to see if giving a lower dose of the drug cyclophosphamide after the transplant can reduce serious side effects while still controlling the cancer. The trial will test four different dose levels in a small group of 26 participants to find the safest and most effective dose.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
cyclophosphamide
What this could lead to
If successful, this could help older patients receive stem cell transplants with fewer severe side effects, making the treatment safer and more tolerable.
What could go wrong
This is a very early phase 1 trial with only 26 participants, so results may not apply broadly. Lowering the dose might increase the risk of graft-versus-host disease or transplant failure.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Cedars-Sinai Medical Center
RECRUITINGLos Angeles, California, 90048, United States
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