Can a standard adult antifungal drug work safely in kids with blood cancer?

NCT ID NCT07357038

Recruiting now Disease control Sponsor: Institute of Hematology & Blood Diseases Hospital, China Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether liposomal amphotericin B (AmBisome) can safely treat breakthrough fungal infections in children and teens with blood cancers who are already on antifungal prevention. About 38 participants will receive the drug as part of their regular care, and researchers will track how well it works and any side effects. The goal is to see if results in children match those seen in adults.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: liposomal amphotericin B (AmBisome)
What this could lead to: If successful, this could show that liposomal amphotericin B is a safe and effective treatment for breakthrough fungal infections in children with blood cancers.
What could go wrong: This is a small, single-center observational study with only 38 participants, so results may not apply broadly. It compares to historical adult data, not a control group, so benefits and risks are uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for FUNGAL DISEASE are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

fungal infectious disease hematopoietic and lymphoid cell neoplasm Invasive Fungal Infections

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FUNGAL DISEASE

Contacts and locations

Locations

National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Hospital
RECRUITING

Tianjin, Tianjin Municipality, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.