HEMATOLOGIC MALIGNANCY

This study is for children with blood cancers or bone marrow disorders who need a stem cell transplant but don't have a perfectly matched donor. It tests a new method using a partially matched family donor, where certain immune cells are removed from the donated cells to help the…

This study tests whether a blood test that measures CMV-specific immunity can help doctors decide how long to use the antiviral drug letermovir after a stem cell transplant. The goal is to prevent late-onset CMV infection, a common complication. The trial involves 250 adults rece…

This study tests whether replacing a standard immune-suppressing drug with tocilizumab can improve stem cell transplant success in 21 adults with blood cancers. The goal is to prevent graft failure and graft-versus-host disease while reducing cancer relapse. Participants receive …

This early-phase trial tests whether giving healthy donor NK cells along with two drugs (vactosertib and IL-2) is safe and helps the cells survive longer in people with advanced colorectal, stomach/esophageal, or blood cancers. About 12 participants will receive the combination t…

This study tests whether benralizumab can safely reduce skin rashes caused by cancer treatments like checkpoint inhibitors. The drug works by lowering eosinophil levels in the blood. About 51 adults with solid tumors or blood cancers who have moderate to severe skin reactions are…

This study tests a mobile app (CARE app) designed to support caregivers of people receiving a bone marrow transplant for blood cancer. The goal is to see if the app improves caregivers' quality of life and reduces stress. About 120 adult caregivers are taking part, and their well…

This study tests a program called PATH-C, which uses positive psychology exercises to improve well-being, quality of life, and physical activity in caregivers of people who have had a stem cell transplant for blood cancer. About 80 adult caregivers will take part. The goal is to …

This study looks at whether an online expressive writing workshop can improve emotional wellness in young adults (ages 18-39) with blood cancer. About 100 participants will take part in a four-week writing program and complete surveys over 12 weeks. Researchers will compare their…

This study follows about 178 people who previously received an experimental AvenCell CAR-T cell therapy for blood cancers or prostate cancer. Researchers will monitor participants for years to check for delayed side effects, such as new cancers, nerve disorders, or severe infecti…

This study follows about 150 people who have already received Caribou cell therapy for blood cancers like lymphoma or leukemia. The goal is to track any long-term side effects for up to 15 years after treatment. No new treatments are given—just regular check-ups to monitor safety…

This study looks at whether older adults with cancer can use computer surveys to share their health information. Researchers will test two different computer methods to see which is easier and more reliable. The goal is to make it simpler for doctors to understand and help their …

This study collects leftover tissue and blood samples from people with known or suspected cancer who are already scheduled for surgery or biopsy. Researchers will compare cancerous and normal tissues to find differences that could lead to new treatments. About 1,200 adults aged 1…