New antibody takes on Hard-to-Treat cancers
NCT ID NCT04243499
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial tests a new drug called ICT01, a lab-made antibody, in 292 people with advanced cancers that have not responded to standard treatments. The drug is given alone or with another cancer drug (Keytruda). The main goals are to check safety and see if the drug can control tumor growth.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ICT01 (a monoclonal antibody targeting BTN3A)
What this could lead to
If successful, this could point toward a new treatment option for advanced cancers that have stopped responding to standard therapies.
What could go wrong
This is an early Phase 1/2 trial, so the main goal is safety, not proof of effectiveness. It may not work for many patients, and side effects are unknown.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Banner MD Anderson Cancer Center
Gilbert, Arizona, 85234, United States
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CHU Lyon
Lyon, France
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CHU Nantes
Nantes, 44093, France
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CHU Poitiers
Poitiers, 86000, France
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Centre Antoine Lacassagne
Nice, 06189, France
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Centre Hospitalier Lyon Sud
Lyon, 69310, France
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Centre Lyon Berard
Lyon, France
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City of Hope Comprehensive Cancer Center
Duarte, California, 91010, United States
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Gustave Roussy
Paris, France
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H. Lee Moffitt Cancer Center and Research Institute
Tampa, Florida, 33612, United States
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Haut Leveque
Bordeaux, 33600, France
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Hospital Universitario HM Sanchinarro
Madrid, 28050, Spain
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Institut Bergonie
Bordeaux, 33000, France
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Institut Curie
Paris, 75248, France
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Institut Jules Bordet
Brussels, Belgium
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Institut Paoli-Calmettes
Marseille, France
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Institute of Cancer Research
London, United Kingdom
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Montefiore Medical Center
The Bronx, New York, 10467, United States
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NHS Greater Glasgow and Clyde, Beatson West of Scotland Cancer Centre
Glasgow, United Kingdom
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Pitie-Salpetriere
Paris, 75013, France
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START Barcelone HM Nou Delfos
Barcelona, 08023, Spain
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START Madrid-FJD, Hospital Fundación Jiménez Díaz
Madrid, 28040, Spain
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The University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
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US Oncology Research
Irving, Texas, 75063, United States
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University Carl Gustav Carus Clinical Trial Unit
Dresden, Germany
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University of Washington
Seattle, Washington, 98133, United States
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Vall d'Hebron Instiute of Oncology
Barcelona, Spain
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Yale Cancer Center
New Haven, Connecticut, 06511, United States
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universitatklinikum Wurburg
Würzburg, Germany