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Immune test could personalize CMV prevention in transplant patients

NCT ID NCT06449586

Ongoing Disease control Sponsor: Ruijin Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a CMV-specific T cell immunity test can help doctors decide how long to give letermovir to prevent late CMV infection after a stem cell transplant. About 250 adults with blood cancers who had a first transplant will take part. The goal is to see if using the test reduces late CMV infections compared to standard care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Letermovir
What this could lead to
If successful, this could show that using an immunity test to personalize letermovir treatment reduces late CMV infections after stem cell transplants.
What could go wrong
This is a Phase 3 trial, but it is still early to know if the approach works better than standard care. The test may not accurately predict infection risk for all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm cytomegalovirus infection prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMATOLOGIC MALIGNANCY

Contacts and locations

Locations

  • Ruijin Hospital of Shanghai Jiaotong University

    Shanghai, Shanghai Municipality, China

  • Ruijin Hospital, Shanghai JiaoTong University School of Medicine

    Shanghai, China

  • Shanghai Liquan Hospital

    Shanghai, China

  • The First Hospital of Zhejiang University School of Medicine

    Hangzhou, Zhejiang, China

  • Tongji Hospital of Huazhong University of Science and Technology, Wuhan

    Wuhan, Hubei, China

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