Precision radiation may boost second stem cell transplants for relapsed blood cancers
NCT ID NCT02333162
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial tests a precise type of radiation (IMTMI) given with chemotherapy before a second donor stem cell transplant for people with advanced blood cancers that have returned. The goal is to find the safest dose and see if it can reduce side effects and prevent the cancer from coming back. The study involves 30 participants and is currently on hold.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Fludarabine phosphate, melphalan, and intensity-modulated total marrow irradiation (IMTMI)
- What this could lead to
- If it works, this could lead to a safer way to prepare the body for a second stem cell transplant, potentially reducing relapse and side effects for people with advanced blood cancers.
- What could go wrong
- This is a very early (Phase I) and small trial (30 people) that is currently suspended. It focuses on safety and dosing, not yet on effectiveness. There are significant risks from the chemotherapy, radiation, and transplant itself.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, 60637, United States
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