Eye implant could replace monthly shots for blinding disease
NCT ID NCT05562947
First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 4 times
Summary
This study tests a small, refillable implant placed in the eye that slowly releases medication for wet age-related macular degeneration (nAMD). It aims to see if refilling the implant every 24 weeks works as well as getting a standard eye injection every 4 weeks. About 68 Chinese patients who have already responded to standard treatment will take part. The main goal is to measure changes in vision over time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ranibizumab delivered via a refillable eye implant (Port Delivery System)
- What this could lead to
- If successful, this implant could allow patients with wet AMD to receive treatment every 6 months instead of monthly injections, reducing clinic visits.
- What could go wrong
- This is a Phase 3 trial with only 68 participants, so results may not apply to all patients. The implant requires surgery and carries risks like infection or implant issues.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for NAMD are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Beijing Hospital
WITHDRAWNBeijing, 100730, China
-
Beijing Tongren Hospital
RECRUITINGBeijing, 100730, China
-
Eye Hospital, Wenzhou Medical University
RECRUITINGWenzhou, 325027, China
-
Peking Union Medical College Hospital
RECRUITINGBeijing, 100032, China
-
Qingdao Eye Hospital of Shandong First Medical University
RECRUITINGQingdao, 266109, China
-
Shanghai First People's Hospital
RECRUITINGShanghai, 200080, China
-
Shanxi Eye Hospital
RECRUITINGTaiyuan, 030002, China
-
Sichuan Provincial People's Hospital
RECRUITINGChengdu, 610072, China
-
The First Affiliated Hospital of China Medical University
RECRUITINGShenyang, 110001, China
-
The Second Affiliated Hospital of Harbin Medical University
RECRUITINGHarbin, 150081, China
-
Tianjin Medical University Eye Hospital
RECRUITINGTianjin, 300070, China
-
Tongji Hospital Tongji Medical College Huazhong University of Science and Technology
RECRUITINGWuhan, 430030, China
-
West China Hospital, Sichuan University
RECRUITINGChengdu, 610041, China
-
Xi'an People's Hospital (Xi'an Fourth Hospital)
RECRUITINGXi'an, China
-
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
WITHDRAWNShanghai, 200092, China
-
Zhongshan Ophthalmic Center, Sun Yat-sen University
RECRUITINGGuangzhou, 510060, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Longer-Lasting eye injection could cut treatment visits for macular disease
- Can a new eye injection save vision in wet AMD?
- Eye injection aims to tame leading causes of blindness
- Higher-Dose eye injection may help wet AMD patients who Didn't respond to standard treatments
- New eye drug aims to save sight in wet AMD
- Withdrawn study sought better way to time eye injections