Can a new eye injection save vision in wet AMD?

NCT ID NCT03834753

Completed Disease control Sponsor: Outlook Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This clinical trial is testing whether an experimental eye injection called ONS-5010 (bevacizumab) can help preserve vision in people with wet age-related macular degeneration (AMD), a leading cause of vision loss. The study will compare ONS-5010 to an existing treatment, ranibizumab, in about 228 participants. The main goal is to see if more people gain significant vision improvement with ONS-5010, while also checking its safety.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: bevacizumab (also called ONS-5010), given as an injection into the eye
What this could lead to: If successful, this could offer another treatment option to help preserve vision in people with wet age-related macular degeneration.
What could go wrong: This is a Phase 3 trial, but results are not guaranteed. The treatment may not be as effective as the comparator, and eye injections carry risks like infection or retinal damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

age-related macular degeneration macular degeneration wet macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

Clinical Site

Tucson, Arizona, 85710, United States
Clinical Site

Arcadia, California, 91007, United States
Clinical Site

Beverly Hills, California, 90211, United States
Clinical Site

Campbell, California, 95008, United States
Clinical Site

Glendale, California, 91203, United States
Clinical Site

Laguna Hills, California, 92653, United States
Clinical Site

Long Beach, California, 90807, United States
Clinical Site

Mountain View, California, 94040, United States
Clinical Site

Oxnard, California, 93036, United States
Clinical Site

Palm Desert, California, 92260, United States
Clinical Site

Poway, California, 92064, United States
Clinical Site

Sacramento, California, 95841, United States
Clinical Site

Santa Maria, California, 93454, United States
Clinical Site

Tustin, California, 92780, United States
Clinical Site

Golden, Colorado, 80401, United States
Clinical Site

Hamden, Connecticut, 06518, United States
Clinical Site

Clearwater, Florida, 33761, United States
Clinical Site

Pinellas Park, Florida, 33782, United States
Clinical Site

Sarasota, Florida, 24233, United States
Clinical Site

Winter Haven, Florida, 33880, United States
Clinical Site

Augusta, Georgia, 30909, United States
Clinical Site

Marietta, Georgia, 30060, United States
Clinical Site

Downers Grove, Illinois, 60615, United States
Clinical Site

Lemont, Illinois, 60439, United States
Clinical Site

Springfield, Illinois, 62704, United States
Clinical Site

Indianapolis, Indiana, 46290, United States
Clinical Site

Hagerstown, Maryland, 21740, United States
Clinical Site

Edina, Minnesota, 55435, United States
Clinical Site

St Louis, Missouri, 63144, United States
Clinical Site

Bloomfield, New Jersey, 07003, United States
Clinical Site

Albuquerque, New Mexico, 87109, United States
Clinical Site

New York, New York, 10021, United States
Clinical Site

Chambersburg, Pennsylvania, 17201, United States
Clinical Site

Monroeville, Pennsylvania, 15146, United States
Clinical Site

Rapid City, South Dakota, 57701, United States
Clinical Site

Germantown, Tennessee, 38138, United States
Clinical Site

Abilene, Texas, 79606, United States
Clinical Site

Amarillo, Texas, 79106, United States
Clinical Site

Arlington, Texas, 76012, United States
Clinical Site

Dallas, Texas, 75231, United States
Clinical Site

Grapevine, Texas, 76051, United States
Clinical Site

Houston, Texas, 77030, United States
Clinical Site

McAllen, Texas, 78503, United States
Clinical Site

San Antonio, Texas, 78240, United States
Clinical Site

San Antonio, Texas, 78251, United States
Clinical Site

The Woodlands, Texas, 77384, United States
Clinical Site

Willow Park, Texas, 76807, United States
Clinical Site

Salt Lake City, Utah, 84107, United States
Clinical Site

Norfolk, Virginia, 23502, United States
Clinical Site

Madison, Wisconsin, 53705, United States

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