New drug combo aims to beat back relapsed leukemia

NCT ID NCT06788756

Recruiting now Disease control Sponsor: Moleculin Biotech, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 06, 2026 · Updated 3 times

Summary

This study tests a new chemotherapy drug, L-Annamycin, combined with standard cytarabine in adults with acute myeloid leukemia (AML) that has come back or not responded to first treatment. About 312 participants will receive either the new drug combo or a placebo plus cytarabine. The goal is to see if L-Annamycin helps more people achieve complete remission after one cycle of treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: L-Annamycin (a chemotherapy drug) combined with cytarabine
What this could lead to: If successful, this could offer a new second-line treatment option for adults with AML that has not responded to or returned after initial therapy.
What could go wrong: This is an early-to-mid-stage trial, so the drug may not prove more effective than placebo. Chemotherapy side effects like infection and organ damage are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute myeloblastic leukemia with maturation acute myeloid leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKAEMIA (AML)

Contacts and locations

Locations

AOU Careggi
RECRUITING

Florence, 50134, Italy
ARENSIA Exploratory Medicine, LLC
RECRUITING

Kyiv, 01135, Ukraine
ARENSIA research clinic at the Oncology Institute "Prof. Dr. Ion Chiricuţă"
RECRUITING

Cluj-Napoca, 400015, Romania
AUSL della Romagna - Santa Maria delle Croci - Ravenna
RECRUITING

Ravenna, 48121, Italy
Atlantic Health
RECRUITING

Morristown, New Jersey, 07960, United States
Augusta University - Georgia Cancer Center
RECRUITING

Augusta, Georgia, 30912, United States
Bioresearch Partners
RECRUITING

Miami, Florida, 33155, United States
Caucasus Medical Center
RECRUITING

Tbilisi, 0186, Georgia
Fakultní nemocnice Hradec Králové
RECRUITING

Hradec Králové, 500 05, Czechia
Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University of the Sacred Heart
RECRUITING

Roma, 00168, Italy
GEORGIA: LLC ARENSIA Exploratory Medicine
RECRUITING

Tbilisi, 0112, Georgia
Hospital MD Anderson Cancer Center Madrid
RECRUITING

Madrid, 28033, Spain
Hospital Universitario Central de Asturias (HUCA)
RECRUITING

Oviedo, Principality of Asturias, 33011, Spain
Hospital Universitario La Fe de Valencia
RECRUITING

Valencia, 46026, Spain
Hospital Universitario Ramón y Cajal
RECRUITING

Madrid, 28034, Spain
Institut Català d'Oncología (ICO) - Hospital Germans Trias i Pujol
RECRUITING

Barcelona, Badalona, 08916, Spain
Instytut Hematologii i Transfuzjologii, Klinika Hematologii
RECRUITING

Warsaw, 02-776, Poland
LSMU Kauno klinikos
RECRUITING

Kaunas, LT-50161, Lithuania
Oddział Hematologii i Transplantacji Szpiku, Uniwersytecki Szpital Kliniczny w Poznaniu
RECRUITING

Poznan, 60-569, Poland
RCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia
RECRUITING

Bologna, 40138, Italy
Szpital Kliniczny MSWiA z Warminsko-Mazurskim Centrum Onkologii w Olsztynie Oddział Kliniczny Hematologii i Chorób Wewnętrznych z Ośrodkiem Transplantacji Szpiku
RECRUITING

Olsztyn, 10-228, Poland
University Hospitals Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States
University of Alabama Birmingham
RECRUITING

Birmingham, Alabama, 35249, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19117, United States
University of Rhode Island
RECRUITING

Providence, Rhode Island, 02903, United States
Uniwersytecki Szpital Kliniczny Klinika Hematologii i Transplantologii (Szczecin)
RECRUITING

Szczecin, 71-252, Poland
Wojewódzki Szpital Zespolony im. L. Rydygiera w Toruniu, Oddział Hematologii
RECRUITING

Torun, 87-100, Poland

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