New drug combo aims to beat back relapsed leukemia
NCT ID NCT06788756
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a new chemotherapy drug, L-Annamycin, combined with standard cytarabine in adults with acute myeloid leukemia (AML) that has come back or not responded to first treatment. About 312 participants will receive either the new drug combo or a placebo plus cytarabine. The goal is to see if L-Annamycin helps more people achieve complete remission after one cycle of treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
L-Annamycin (a chemotherapy drug) combined with cytarabine
What this could lead to
If successful, this could offer a new second-line treatment option for adults with AML that has not responded to or returned after initial therapy.
What could go wrong
This is an early-to-mid-stage trial, so the drug may not prove more effective than placebo. Chemotherapy side effects like infection and organ damage are possible.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Locations
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AOU Careggi
RECRUITINGFlorence, 50134, Italy
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ARENSIA Exploratory Medicine, LLC
RECRUITINGKyiv, 01135, Ukraine
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ARENSIA research clinic at the Oncology Institute "Prof. Dr. Ion Chiricuţă"
RECRUITINGCluj-Napoca, 400015, Romania
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AUSL della Romagna - Santa Maria delle Croci - Ravenna
RECRUITINGRavenna, 48121, Italy
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Atlantic Health
RECRUITINGMorristown, New Jersey, 07960, United States
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Augusta University - Georgia Cancer Center
RECRUITINGAugusta, Georgia, 30912, United States
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Bioresearch Partners
RECRUITINGMiami, Florida, 33155, United States
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Caucasus Medical Center
RECRUITINGTbilisi, 0186, Georgia
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Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University of the Sacred Heart
RECRUITINGRoma, 00168, Italy
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GEORGIA: LLC ARENSIA Exploratory Medicine
RECRUITINGTbilisi, 0112, Georgia
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Hospital MD Anderson Cancer Center Madrid
RECRUITINGMadrid, 28033, Spain
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Hospital Universitario Central de Asturias (HUCA)
RECRUITINGOviedo, Principality of Asturias, 33011, Spain
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Hospital Universitario La Fe de Valencia
RECRUITINGValencia, 46026, Spain
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Hospital Universitario Ramón y Cajal
RECRUITINGMadrid, 28034, Spain
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Institut Català d'Oncología (ICO) - Hospital Germans Trias i Pujol
RECRUITINGBarcelona, Badalona, 08916, Spain
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Instytut Hematologii i Transfuzjologii, Klinika Hematologii
RECRUITINGWarsaw, 02-776, Poland
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LSMU Kauno klinikos
RECRUITINGKaunas, LT-50161, Lithuania
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Oddział Hematologii i Transplantacji Szpiku, Uniwersytecki Szpital Kliniczny w Poznaniu
RECRUITINGPoznan, 60-569, Poland
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RCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia
RECRUITINGBologna, 40138, Italy
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Szpital Kliniczny MSWiA z Warminsko-Mazurskim Centrum Onkologii w Olsztynie Oddział Kliniczny Hematologii i Chorób Wewnętrznych z Ośrodkiem Transplantacji Szpiku
RECRUITINGOlsztyn, 10-228, Poland
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University Hospitals Cleveland Medical Center
RECRUITINGCleveland, Ohio, 44106, United States
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University of Nebraska Medical Center
RECRUITINGOmaha, Nebraska, 68198, United States
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University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19117, United States
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Uniwersytecki Szpital Kliniczny Klinika Hematologii i Transplantologii (Szczecin)
RECRUITINGSzczecin, 71-252, Poland
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Wojewódzki Szpital Zespolony im. L. Rydygiera w Toruniu, Oddział Hematologii
RECRUITINGTorun, 87-100, Poland
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