Scientists hunt for genetic clues behind childhood pituitary tumors

NCT ID NCT00001595

Recruiting now Knowledge-focused Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 05, 2026 · Updated 7 times

Summary

This study aims to uncover the genetic causes of pituitary and hypothalamic tumors in children. Researchers will collect blood and tumor samples from up to 2,000 participants to analyze DNA and look for inherited patterns. The study also trains doctors and tests new MRI techniques to better detect these tumors. While it does not offer a direct treatment, the findings could pave the way for future therapies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could uncover genetic roots of childhood pituitary tumors, leading to better diagnostic tools and targeted therapies in the future.
What could go wrong: This is an observational study focused on understanding the disease, not testing a treatment. It may not directly benefit participants, and results may take years to translate into clinical practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acromegaly ACTH-dependent Cushing syndrome Carcinogenesis Combined Pituitary Hormone Deficiency Congenital Abnormalities craniopharyngioma Cushing disease due to pituitary adenoma hypothalamic neoplasm panhypopituitarism pituitary gigantism pituitary tumor prolactin-producing pituitary gland adenoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CUSHING DISEASE GIGANTISM/ACROMEGALY PANHYPOPITUITARISM PROLACTINOMA

Contacts and locations

Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

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