New antibody GEN3018 enters first human tests for tough blood cancers

NCT ID NCT07384715

Recruiting now Disease control Sponsor: Genmab Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 05, 2026 · Updated 5 times

Summary

This early-stage trial is testing a new antibody drug called GEN3018 in people whose acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) has come back or stopped responding to treatment. The main goal is to check safety and find the right dose. Up to 78 participants will receive the drug by IV, and the study will monitor them closely for side effects and any signs that the drug is working.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: GEN3018 (an antibody given by IV infusion)
What this could lead to: If it works, this could point toward a new treatment option for people with hard-to-treat blood cancers like AML and MDS.
What could go wrong: This is a very early, first-in-human trial focused on safety, not effectiveness. The drug may not work or could have serious side effects. Only 78 people will be enrolled, so results may not apply to everyone.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia myelodysplastic syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA HIGHER-RISK MYELODYSPLASTIC SYNDROME R/R AML R/R HR-MDS

Contacts and locations

Locations

Aarhus Universitetshospital - Skejby
RECRUITING

Aarhus, 8200, Denmark
Copenhagen Rigshospitalet
RECRUITING

Copenhagen, 2100, Denmark
Hospital Clínic de Barcelona
NOT_YET_RECRUITING

Barcelona, 08036, Spain
Hospital Universitari Vall d'Hebron
NOT_YET_RECRUITING

Barcelona, 08035, Spain
Hospital Universitari i Politècnic La Fe
RECRUITING

Valencia, 46026, Spain
Hospital Universitario 12 de Octubre
NOT_YET_RECRUITING

Madrid, 28041, Spain

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