Can a simple hydrogen drink ease chronic fatigue?

NCT ID NCT07753122

Recruiting now Symptom relief Sponsor: Fred Friedberg Source: ClinicalTrials.gov ↗

First seen Aug 07, 2026 · Last updated Aug 07, 2026

Summary

This trial tests whether drinking hydrogen-rich water for 16 weeks can reduce fatigue and improve physical functioning in people with ME/CFS (chronic fatigue syndrome). Half of the 80 participants will receive the active supplement, while the other half gets a placebo. The study also checks if a heart-rate variability measure can predict who improves, which could help personalize future treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Molecular hydrogen produced by a metallic magnesium tablet dissolved in water, taken three times daily for 16 weeks.
What this could lead to: If effective, hydrogen water could offer a simple, over-the-counter option to reduce fatigue and improve daily functioning in ME/CFS.
What could go wrong: This is a small, early-stage trial, and the supplement may prove no better than placebo. The biomarker prediction is exploratory and not yet confirmed.

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Conditions

The condition(s) this trial relates to.

myalgic encephalomeyelitis/chronic fatigue syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC FATIGUE SYNDROME (CFS)

Contacts and locations

Locations

Stony Brook University
RECRUITING

Stony Brook, New York, 11794-6000, United States

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