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New injection could ease jaw pain better than standard treatment

NCT ID NCT07075276

Recruiting now Symptom relief Sponsor: Horus University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares a new injection of liquid phase concentrated growth factor (LPCGF) to standard arthrocentesis (joint washing) for people with painful jaw clicking and limited mouth opening due to a displaced disc. Thirty-two adults aged 18-45 with unilateral disc displacement will be randomly assigned to one of the two procedures. The goal is to see if LPCGF reduces pain and improves mouth opening more than the conventional treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Liquid Phase Concentrated Growth Factor (LPCGF)
What this could lead to
If it works, this could offer a more effective, less invasive option for treating painful jaw clicking and limited mouth opening.
What could go wrong
This is a small, early-stage trial with only 32 participants, so results may not apply to everyone. The treatment is compared to a standard procedure, and benefits may be modest.

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Conditions

The condition(s) this trial relates to.

temporomandibular joint disorder temporomandibular joint dysfunction syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANTERIOR DISC DISPLACEMENT INTERNAL DERANGEMENT OF THE TEMPROMANDIBULAR JOINT TEMPOROMANDIBULAR DISORDERS (TMD)

Contacts and locations

Locations

  • Faculty of Dentistry- Horus University in Egypt

    RECRUITING

    Damietta, New Damietta, 34518, Egypt

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