Musculoskeletal system disorder

This early-stage trial is testing an experimental cell therapy for people with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) that has returned or not responded to standard treatments. The therapy uses a patient's own immune cells, modified to recognize …

This trial tests a new, lower-intensity combination of chemotherapy and radiation before a donor stem cell transplant for people with high-risk blood cancers or aplastic anemia. The goal is to see if this approach is safe enough to allow the donor cells to take hold and cure the …

This trial tests whether transplanting a patient's own minced pulp tissue into a cleaned root canal can regenerate living dental pulp. Fifty participants aged 7 to 50 with infected or inflamed teeth will receive either standard root canal treatment or the experimental tissue tran…

This study tests a new two-drug combination (pacritinib plus azacitidine) for people with moderate to very high risk myelodysplastic syndrome (MDS), a bone marrow disorder. The first part finds the safest dose of pacritinib, and the second part checks how well the combination wor…

This study tests whether a lower dose of the drug cyclophosphamide, given after a stem cell transplant from a partially matched donor, can reduce serious infections in the first 100 days while still preventing graft-versus-host disease (a common complication where donor cells att…

This pilot study tests whether using a videoscope—a small camera that gives surgeons a magnified, clearer view—during minimally invasive gum surgery improves outcomes for people with severe chronic periodontitis. Participants are randomly assigned to receive surgery with the vide…

This study is testing a new knee implant called the Persona SoluTion PPS femur in 200 adults who need total knee replacement. The goal is to see if it safely improves knee function and reduces pain over two years. Participants will have their knee health measured before surgery a…

This study tests whether a piece of donated aorta (the body's largest artery) can be used as a patch to repair severe windpipe or bronchial defects in children. The surgery is for kids who cannot have standard windpipe repair. Only 5 children will be enrolled, and the main goal i…

This trial tests whether a brain-computer interface (BCI) can guide electrical stimulation to improve leg muscle activation and walking in people with spinal cord injury. Participants imagine moving their ankles while a device reads their brain signals and triggers electrical sti…

This phase 3 trial is testing whether adding radiation therapy to standard care can prevent bone complications like fractures or spinal cord compression in cancer patients with high-risk bone metastases that aren't causing symptoms yet. About 280 patients with multiple metastatic…

This study is testing the Persona Ti-Nidium knee implant in 240 people who need total knee replacement due to conditions like osteoarthritis or rheumatoid arthritis. The goal is to see if the implant is safe and improves knee function and pain. Participants will be followed over …

This trial aims to see if there is a difference in how well two cementless total knee replacement implants hold up over time. About 50 people with knee osteoarthritis will be randomly assigned to receive either the Triathlon Tritanium or the GMK Sphere implant. Using CT scans, re…

This early-stage study tests a single intravenous dose of a gene therapy called LY3884961 in 15 adults with Gaucher disease type 1. The goal is to see if it is safe and can reduce or replace the need for ongoing enzyme replacement or substrate reduction therapy. Participants must…

This study tests a weekly injection called TransCon CNP in children and teens with achondroplasia, the most common form of dwarfism. The goal is to see if it is safe and helps improve growth over several years. Participants who completed a previous TransCon CNP trial can join thi…

This study tests a new treatment called Orca-T for people with advanced blood cancers like leukemia. It uses a special mix of stem cells and immune cells from a donor to help the body accept the transplant while reducing serious side effects like graft-versus-host disease. The go…

This trial tests whether adding screws to secure the cup part of a hip replacement makes a difference in how well the implant stays in place. Participants aged 65-80 with hip osteoarthritis will receive a hybrid hip replacement, and half will get screws while the other half won't…

This study compares two conservative methods for treating deep tooth decay that reaches close to the nerve. In one approach, dentists leave softer decayed tissue near the nerve; in the other, they remove more until firmer tissue remains. About 100 patients with deep decay in perm…

This phase 2 study tests a combination of two nucleoside drugs, doxecitine and doxribtimine, in 47 people with thymidine kinase 2 (TK2) deficiency, a rare genetic disorder that weakens muscles. Participants already receiving nucleoside therapy continue treatment to see if the dru…

This study tests whether stem cells from donated umbilical cords can help boys with Duchenne muscular dystrophy (DMD). The cells are given through a vein and are meant to reduce inflammation and improve muscle function. The trial includes boys aged 5 to 10 who can still walk and …

This study is testing the long-term safety and effectiveness of bimekizumab, a drug that reduces inflammation, in 508 adults with active axial spondyloarthritis (including ankylosing spondylitis). Participants who completed earlier trials will receive the drug for an extended per…

This trial is testing whether adding the targeted drug cabozantinib to standard chemotherapy (methotrexate, doxorubicin, and cisplatin) helps people with newly diagnosed osteosarcoma, a type of bone cancer. The study includes over 1,100 participants and aims to see if the combina…

This study tests a new growth hormone medicine called somapacitan, given once a week, in 47 children who are very short due to being born small for gestational age, or having Turner syndrome, Noonan syndrome, or idiopathic short stature. The main goal is to see if it is safe and …

This trial compares two ways to treat a severely decayed tooth that has caused irreversible pulpitis, a painful condition where the tooth's inner pulp is inflamed. One method uses a standard solution to control bleeding after removing damaged pulp, while the other uses a diode la…

This study tests a new drug called bomedemstat against the best available treatments for people with essential thrombocythemia (a blood disorder causing too many platelets) who did not respond well to or couldn't tolerate the standard drug hydroxyurea. About 340 adults will be ra…

This trial tests whether a less invasive dental procedure called pulpotomy can successfully treat baby molars with a severe, painful tooth condition known as irreversible pulpitis. Instead of removing the entire nerve, pulpotomy removes only the top part and places a soothing med…

This phase 2 trial tested vismodegib, a pill that targets a specific growth pathway, in 45 people with advanced chondrosarcoma (a rare bone cancer). The goal was to see if the drug could shrink tumors or stop them from growing. Participants had to have measurable disease and no m…

This trial compares the drug ruxolitinib against the best available standard treatments for people with high-risk polycythemia vera (PV) or essential thrombocythemia (ET), two rare blood cancers that cause overproduction of blood cells and can lead to clots, bleeding, and severe …

This trial compares two surgical techniques for treating receding gums, a condition where the gum tissue pulls away from the teeth, exposing the roots. One technique is the standard coronally advanced flap, and the other is a newer vertical variation. Both are performed along wit…

This study is testing a new type of hip resurfacing device made entirely of ceramic, designed for people with hip osteoarthritis, necrosis, or dysplasia. The goal is to see if it is as safe and effective as existing metal-on-metal devices, but without releasing metal ions into th…

This phase 3 trial is testing whether ropeginterferon alfa-2b, a biologic drug, can help control blood cell counts and symptoms in adults with early or low-risk primary myelofibrosis, a bone marrow disorder. Participants receive either the drug or a placebo every two weeks for up…

This study tests satralizumab, a drug that calms inflammation, in 30 children aged 8 to 17 with Duchenne muscular dystrophy. The goal is to see if it improves bone density and muscle function. Participants receive injections for several months while continuing standard steroid th…

This trial tests five different materials placed beneath composite fillings in back teeth to see which one best supports the filling and keeps it firmly attached. Adults needing a standard back-tooth filling will receive one of the five materials at random. Dentists will check th…

This phase 1 trial is testing an experimental pill called flonoltinib maleate in people with certain bone marrow tumors, including myelofibrosis, polycythemia vera, and essential thrombocythemia. The drug targets two proteins involved in abnormal blood cell growth. The study aims…

This phase 3 trial tests whether taking tranexamic acid (TXA) by mouth for an extended period after total knee replacement can improve recovery. TXA is already used during surgery to reduce bleeding, but its benefits when continued afterward are unclear. The study will compare di…

This study compares two dental procedures for treating severe pulpitis (tooth nerve inflammation) in children's baby molars. One is a standard full root canal treatment (pulpectomy), and the other is a less invasive option that removes only part of the nerve (pulpotomy). The goal…

This study follows people with knee osteoarthritis who receive one of two total knee replacement designs: a cruciate-retaining (CR) or a posterior-stabilized (PS) implant. The goal is to compare how well each design relieves pain, restores function, and holds up over time. Resear…

This study tests whether the drug ixekizumab is safe and effective for children with certain types of juvenile arthritis (enthesitis-related arthritis and juvenile psoriatic arthritis). About 101 children aged 2 to 17 years will receive either ixekizumab or the standard drug adal…

This trial is testing an experimental drug called flonoltinib in people with intermediate to high-risk myelofibrosis, a type of bone marrow cancer that often causes an enlarged spleen. Participants will be randomly assigned to receive either a low or high dose of flonoltinib, or …

This study tests a drug called sonelokimab in 960 adults with active psoriatic arthritis who have not used biologic treatments before. The goal is to see if it reduces joint pain and swelling better than a placebo. Participants receive injections over several months, and research…

This study looks at how the part of a dental crown that sits under the gums is shaped and whether that shape helps keep gums and bone healthy. Thirty people with gum disease who already have a dental implant will get a custom crown. Researchers will measure bone loss, gum thickne…

This study is testing a device called KeriFuse® that is implanted into the finger joint to fuse the bones together. It is for people with arthritis in the last joint of the finger or thumb. The goal is to see if it reduces pain and successfully fuses the joint within three months…

This early-phase study tests a new drug called INCB160058 in adults with myeloproliferative neoplasms, a group of rare blood cancers. The main goal is to check the drug's safety and how the body processes it. About 186 participants will receive the drug to find the right dose and…

This trial is testing two different cup designs for total hip replacement, both paired with the same stem, to see which one gives patients better hip function and less pain. About 120 people with hip arthritis or related conditions will be randomly assigned to receive either the …

This study compares two ways to treat deep cavities in young permanent teeth without exposing the nerve. In selective excavation, the dentist removes only the outer decay and seals the tooth. In stepwise excavation, they place a temporary filling first and remove more decay a few…

This study compares three materials used to treat deep cavities in children's baby molars: a standard dental cement (MTA), a bleeding-stopping liquid (ferric sulfate), and a new natural gel made from shellfish shells (chitosan). 165 children aged 5-8 will receive one of these tre…

This study follows 299 people who received the Smith+Nephew Porous Total Knee System, a titanium knee replacement for severe arthritis. The goal is to see if the implant reduces pain, improves movement, and lasts at least two years without needing revision surgery. Participants a…

This trial compares two dental procedures—direct pulp capping and partial pulpotomy—for treating permanent teeth with deep cavities that expose the pulp. Adults with deep caries and reversible pulpitis will be randomly assigned to one of the two procedures. The study will follow …

This study tests a special drilling technique called osseodensification to widen narrow jawbone so dental implants can be placed without extra bone grafting. Thirty adults with healed tooth sockets and narrow ridges will have their bone width measured before and after the procedu…

This trial compares two types of knee replacement implants: one that keeps the posterior cruciate ligament (CR) and one that does not (PS). Both are implanted using a computer-assisted personalized technique that aims to restore the knee's natural alignment. The study includes 14…

This study tests whether baricitinib, a daily pill, is safe and works for children aged 1 to under 18 with systemic juvenile idiopathic arthritis (sJIA), a chronic inflammatory disease. About 58 children will receive either baricitinib or a standard injected drug (tocilizumab) to…

This study tests whether the level of a specific inflammatory marker (MMP9) in the dental pulp can predict the success of a full pulpotomy, a procedure that removes the inflamed pulp from the crown of a tooth and seals it with a special material. Adults with deep cavities causing…

This trial is testing an investigational drug called DYNE-251 in boys with Duchenne muscular dystrophy (DMD) who have a specific genetic mutation. The goal is to see if the drug can safely help their muscles produce dystrophin, a protein that is missing in DMD. Participants recei…

This study tests a single dose of SGT-001 gene therapy in 12 boys (children and teens) with Duchenne muscular dystrophy. The main goal is to check safety and how well the body tolerates the treatment. Participants will be followed for about 5 years to monitor side effects and any…

This early-stage trial is testing a new drug called INCA033989, alone or with an existing drug ruxolitinib, in 225 people with myeloproliferative neoplasms (a group of blood cancers). The main goal is to check safety and find the best dose. Participants must have a specific genet…

This trial compares two surgical procedures for people with painful thumb base osteoarthritis that hasn't improved with conservative care. One procedure removes the entire trapezium bone, while the other removes only a small portion to create a narrow gap. The study will track pa…

This Phase 3 trial tests an experimental drug called ALXN2220 in about 1,180 adults with transthyretin amyloid cardiomyopathy (ATTR-CM), a condition where abnormal protein builds up in the heart, causing heart failure. The drug is designed to remove those protein deposits. Partic…

This trial tests whether injecting platelet-rich plasma (PRP) into the thumb joint can reduce pain and improve function in people with thumb base osteoarthritis. Participants are randomly assigned to receive either PRP or a saline placebo injection, and neither they nor the resea…

This study tests a new medicine called INZ-701 in babies up to 1 year old who have a rare genetic condition (ENPP1 deficiency) that causes severe hardening of the arteries and bone problems. The goal is to see if the drug can raise a key substance in the blood, improve survival, …

This trial is testing an oral drug called AG-120 (ivosidenib) in adults with myelodysplastic syndrome (MDS) or a related early form of leukemia that carries a specific IDH1 gene mutation. The drug is designed to block the mutated enzyme that drives abnormal blood cell growth. Res…

This study tests a new way to treat adults with a specific type of leukemia (Ph+ ALL) that has come back or not responded to treatment. The approach combines low-intensity chemotherapy with two targeted drugs, ponatinib and blinatumomab, to kill cancer cells and boost the immune …

This trial compares two surgical approaches for a common type of ankle fracture. Half of the participants will have the posterior bone fragment fixed with a plate or screw, while the other half will not. The goal is to see if fixing this fragment makes the ankle joint stable enou…

This study tests the long-term safety and effectiveness of an experimental drug called VX-670 in adults with myotonic dystrophy type 1 (DM1). Participants who completed a previous VX-670 study can join. The drug is given through a vein, and researchers will monitor side effects a…

This trial is testing an oral drug called enasidenib (AG-221) in people with myelodysplastic syndrome (MDS) who have a specific genetic change called an IDH2 mutation. The drug is designed to block the mutated enzyme and help restore normal blood cell production. Participants rec…

This early-phase trial tests a drug called DR-18 in 40 adults with acute myeloid leukemia or myelodysplastic syndrome whose cancer returned or persisted after a stem cell transplant. DR-18 is a modified immune protein designed to boost the body's natural defenses against cancer c…

This study tests a new 3D-printed implant for adults with hip dysplasia, a condition where the hip socket doesn't fully cover the thigh bone, causing pain and gait problems. Ten participants aged 18-45 will receive the implant to see if it is safe and helps improve hip function a…

This study tests a new drug called INZ-701 in up to 16 infants (up to 1 year old) with rare genetic conditions (ENPP1 or ABCC6 deficiency) that cause dangerous calcium buildup in arteries and other problems. The main goal is to check the drug's safety and how the body handles it,…

This trial is testing whether a single injection of micrografts made from a patient's own ear cartilage can improve symptoms and knee function in adults with moderate knee osteoarthritis. The micrografts are prepared from a small ear cartilage sample using a special device, witho…

This study tests a gene therapy called delandistrogene moxeparvovec in 13 children under age 4 with Duchenne muscular dystrophy. The goal is to see if it is safe and can help produce a key muscle protein. The children will be followed for about 5 years.

This early-phase trial tests a single intravenous dose of LY-M001 gene therapy in 9 children (ages 6 to 17) with type 1 Gaucher disease. The goal is to see if it is safe and can improve key symptoms like liver size and blood markers. Researchers will monitor participants for side…

This early-phase trial tests two oral drugs, olutasidenib and ziftomenib, together in 20 adults with a specific form of acute myeloid leukemia (AML) that has returned or not responded to treatment. The first part finds a safe dose; the second checks if that dose helps control the…

This trial tests whether applying a gel containing hyaluronic acid and chlorhexidine after a minimally invasive deep cleaning can improve gum healing in people with advanced periodontitis (stage III or IV). Participants receive either the deep cleaning alone or the cleaning plus …

This study tests whether adding concentrated platelet-rich fibrin (C-PRF), a gel made from a patient's own blood, to a minimally invasive non-surgical gum treatment can improve healing in people with advanced periodontitis. Thirty adults with severe gum disease and deep bone defe…

This study tests a new device that uses extreme cold (cryoablation) to treat a fast, dangerous heart rhythm called sustained monomorphic ventricular tachycardia. About 206 adults with this condition will receive the freezing treatment. The goal is to see if it safely stops the ab…

This study tests two drugs, vorinostat and azacitidine, together in people with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). The goal is to find the best dose and see if the combination is safe and effective. About 135 participants will take part in this early-…

This study tests a specific timing of chemotherapy drugs (busulfan and fludarabine) before a donor stem cell transplant, followed by cyclophosphamide after the transplant, to treat high-risk blood cancers like leukemia and lymphoma. The goal is to reduce the chance of the transpl…

This study tested a simplified care plan for people with acute promyelocytic leukemia (APL), a rare blood cancer. The goal was to see if following easy-to-use guidelines and getting support from APL experts could lower the number of deaths soon after starting treatment. About 200…

This study looks at whether a special dental sealer (bioceramic) helps heal infections and reduces pain after a repeat root canal done in one visit. About 70 adults with failed root canals and silent infections in their back teeth will take part. They will get the new sealer or a…

This study is for adults with a specific type of acute myeloid leukemia (CD123+ AML) who cannot receive standard strong chemotherapy. It tests a new drug, tagraxofusp, added to two other drugs (venetoclax and azacitidine) to see if it helps more people achieve complete remission.…

This study tests whether adding the drug selinexor to standard chemotherapy can help older adults with untreated acute myeloid leukemia (AML) live longer and achieve remission. About 57 participants will receive either standard chemo alone or chemo plus selinexor, followed by mai…

This phase 4 study tests the drug mavacamten in 63 adults with a type of heart muscle disease called obstructive hypertrophic cardiomyopathy. The goal is to see if the drug can improve heart structure, measured by MRI, and ease symptoms like shortness of breath. Participants take…

This trial tests whether an investigational drug called SHR-1314 can reduce joint pain, swelling, and skin symptoms in adults with active psoriatic arthritis. Participants receive either SHR-1314 or a placebo injection over 24 weeks, with follow-up for safety. The study aims to s…

This study looks at whether doing blood flow-restricted exercise two or three times per week makes a difference in muscle strength recovery for people with incomplete cervical spinal cord injury. Participants perform low-load muscle contractions while a cuff partially restricts b…

This study compares two standard surgeries for people aged 60 and older with a severe three-tendon tear in the shoulder: reverse total shoulder replacement versus rotator cuff repair. Researchers will measure shoulder function, pain, and satisfaction one year after surgery to see…

This study tests two strategies to keep acute myeloid leukemia (AML) from coming back in people aged 65 and older who have achieved remission after initial treatment. One group receives a stem cell transplant, while the other continues on a maintenance drug combination of azaciti…

This study tests an oral drug called ONC201 in people whose acute leukemia or high-risk myelodysplastic syndrome (MDS) has returned or not responded to standard treatments. The trial has two phases: Phase I finds the safest dose, and Phase II checks if the drug shrinks or control…

This early-stage trial is testing an experimental oral drug, TYRA-200, in people with advanced bile duct cancer (intrahepatic cholangiocarcinoma) and other solid tumors that have specific changes in the FGFR2 gene. The study aims to find a safe and effective dose and to see wheth…

This phase 2 trial tests whether daratumumab, an antibody that targets cancer cells, can improve outcomes for people with multiple myeloma after they receive a stem cell transplant. The study involves 31 participants and is currently active but not recruiting. The main goal is to…

This study tests whether adding the targeted therapy cabozantinib to standard immunotherapy (nivolumab and ipilimumab) helps people with advanced kidney cancer live longer. About 1,175 adults with kidney cancer that has spread will receive either the usual treatment or the usual …

This trial tests whether adding pelvic floor muscle training to standard scoliosis-specific exercises can better reduce spine curvature in adolescents with idiopathic scoliosis. Participants aged 10-18 with mild to moderate curves will be randomly assigned to either exercises alo…

This trial tests whether a 12-week program of physical therapy or home exercises can reduce pain and improve shoulder function in adults with glenohumeral arthritis, compared with no treatment. Participants are randomly assigned to one of three groups: supervised physical therapy…

This study tests an experimental drug, HT-6184, in adults with a bone marrow disorder called myelodysplastic syndrome (MDS) who have low red blood cell counts (anemia). The goal is to see if the drug can improve blood counts and reduce the need for transfusions. Participants take…

This early-stage trial is testing a new treatment called CC-97540, which uses a patient's own immune cells modified to target and destroy faulty immune cells. It is for people with severe forms of lupus, myositis, scleroderma, or rheumatoid arthritis that have not improved with s…

This study tests whether adding an immunotherapy drug (pembrolizumab) to standard chemotherapy (azacitidine and venetoclax) can improve outcomes for older adults with newly diagnosed acute myeloid leukemia (AML) who cannot have intensive chemo. About 60 participants will be rando…

This early-phase study tested a new gene editing treatment called HG302 in 4 boys with Duchenne muscular dystrophy (DMD), a severe muscle-wasting disease. The therapy uses CRISPR technology to fix the genetic error and help muscles produce dystrophin, a protein essential for musc…

This study tests a one-time gene therapy called RGX-314 for wet age-related macular degeneration (AMD), a leading cause of vision loss. About 714 adults aged 50-89 who currently need regular eye injections will receive either the gene therapy or standard treatment. The goal is to…

This study tests whether adding ASTX727 to the standard drug dasatinib can better control chronic myeloid leukemia (CML) in newly diagnosed patients. About 70 adults with a specific genetic marker (Philadelphia chromosome) will receive both pills. The goal is to see if the combin…

This trial is testing whether a single injection of stem cells taken from a patient's own belly fat can ease the pain and improve the function of knees damaged by osteoarthritis. Half of the participants will receive the stem cell treatment, while the other half will get a placeb…

This study is testing an oral medication called upadacitinib in children with polyarticular juvenile idiopathic arthritis (JIA), a condition causing joint inflammation. The goal is to understand how the drug moves through the body, its safety, and how well children tolerate it. P…

This study tests whether combining olaparib and temozolomide works better than standard drugs (trabectedin or pazopanib) for people with advanced uterine leiomyosarcoma that has spread or cannot be removed by surgery and has stopped responding to initial chemotherapy. About 74 pa…

This early-stage trial is testing whether stem cells from a donor can help control heart failure in people whose hearts were weakened by a type of chemotherapy called anthracyclines. About 72 participants will either receive standard care alone or standard care plus stem cells gi…

This trial investigates whether ropeginterferon alfa-2b can help people with polycythemia vera, a condition where the body makes too many red blood cells. The study will compare the drug to standard care, which includes phlebotomy (removing blood) and aspirin. About 70 adults wit…

This trial tests whether a structured 16-week corrective exercise program can improve spinal alignment in adolescents aged 10–18 with mild to moderate scoliosis (Cobb angle 10°–40°). Participants are randomly assigned to either the corrective program or standard physiotherapy. Th…

This phase 2 trial tests an experimental drug called AOC 1044 in people with Duchenne muscular dystrophy whose genetic mutation makes them candidates for exon 44 skipping therapy. The drug is given by intravenous infusion. Researchers are evaluating long-term safety and whether i…

This trial tests whether placing a temporary crown immediately after a dental implant helps keep gum tissue stable compared to placing the implant alone. About 44 adults with a non-restorable front tooth will be randomly assigned to one of the two approaches. Researchers will mea…

This trial compares two types of knee replacement implants in people aged 75 and older: a standard metal-backed component and a cheaper all-polyethylene (plastic) one. The goal is to see if the all-polyethylene implant performs as well in terms of pain relief, movement, and how l…

This phase I trial is testing whether a combination of three treatments — an experimental drug called elimusertib, precise radiation therapy, and the immunotherapy pembrolizumab — can shrink or stabilize recurrent head and neck cancer that cannot be removed by surgery. The study …

This trial compares two marketed brands of silver diamine fluoride (SDF) to see which is more effective at stopping tooth decay in children aged 4 to 7. Both treatments are applied to cavities and leave a black stain. Researchers will follow the children for one year, checking wh…

This phase 2 trial is testing whether combining daratumumab, venetoclax, and dexamethasone can produce a deep and rapid response in people newly diagnosed with light-chain (AL) amyloidosis who carry a specific genetic marker called t(11;14). The study enrolls 36 participants and …

This trial tests whether a thin, strong fiber splint glued to the back of loose front teeth can keep them stable for a year. The splint is made of ultra-high molecular weight polyethylene and is placed after standard gum treatment. Researchers will track how many teeth survive, h…

This trial tests whether an 8-week course of the immunosuppressive drug prednisone can reduce episodes of ventricular tachycardia (a potentially fatal fast heart rhythm) and improve heart function in people with non-ischemic cardiomyopathy and confirmed heart inflammation. Partic…

This study looks at how well a surgical technique called AMIC holds up ten years after repairing cartilage damage in the ankle. Researchers are checking whether the pain relief and function patients gained in the first few years remain stable or fade over time. About 40 people wh…

This trial compares two treatments applied during surgery to help heal jaw bone damage caused by bisphosphonates or similar drugs. One is an oxygen-based gel, the other is a membrane made from the patient's own platelets. Researchers will measure how completely the bone and soft …

This trial tests whether a focused form of brain stimulation called high-definition transcranial direct current stimulation (HD-tDCS) can improve arm and hand function in people with cervical spinal cord injury. Participants receive either HD-tDCS or conventional stimulation duri…

This trial investigates whether a single or repeat infusion of zoledronate, or daily oral alendronate, can maintain the bone density improvements achieved with denosumab in postmenopausal women with osteoporosis. Participants who have been on denosumab for at least three years wi…

This phase 3 trial compares the biologic drug P1101 (ropeginterferon alfa-2b) against the standard drug anagrelide in people with essential thrombocythemia, a rare blood cancer that causes too many platelets. The study enrolls adults who have not responded well to the first-line …

This study tests an experimental oral drug called LY3410738 in people with advanced blood cancers such as acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) that have specific IDH1 or IDH2 gene mutations. The drug is designed to block the mutated IDH proteins that he…

This phase II trial tests whether simvastatin, a widely used cholesterol medication, can reduce the size of uterine fibroids and ease related symptoms. Researchers will give 60 women either simvastatin or a placebo daily for 12 weeks, measuring fibroid volume by ultrasound and tr…

This study tests whether a digital expert team can help people on long-term sick leave with muscle or common mental health issues return to work. Participants fill out a digital questionnaire and have a video meeting with their doctor and a team of specialists who then create a p…

This phase 3 trial tests whether cabergoline, a drug already used for hormone-producing pituitary tumors, can shrink or slow the growth of non-functioning pituitary adenomas (NFPAs). These tumors do not produce excess hormones, so current treatment is limited to surgery or radiat…

This study tests whether a less invasive partial pulpotomy works as well as the standard full pulpotomy for treating deep cavities in children's baby molars. Both procedures use MTA, a material that helps heal the tooth's pulp. The trial enrolls healthy children aged 4-8 with mat…

This study tests an experimental drug, BBP-418, in people with limb girdle muscular dystrophy type 2I (LGMD2I), a rare genetic condition that causes progressive muscle weakness. The drug aims to fix a molecular defect by helping a faulty enzyme work better. The trial includes bot…

This trial tests whether coating clear orthodontic aligners with nano chitosan—a natural antimicrobial—can reduce white spot lesions (early enamel damage) that sometimes develop during aligner therapy. About 53 people with mild to moderate misalignment will wear either coated or …

This trial compares two surgical techniques for treating cervical degenerative disc disease: using a stand-alone cage versus a cage-screw fixation system. Both aim to relieve pain and improve function by removing the damaged disc and fusing the vertebrae. The study measures pain …

This study tests whether giving patients hyperbaric oxygen (breathing pure oxygen in a pressurized chamber) after an umbilical cord blood stem cell transplant helps the donated stem cells grow faster. The trial enrolls people with blood cancers like leukemia or lymphoma who lack …

This trial tests whether giving a low-dose infusion of desmopressin (dDAVP) during surgery for complex brain tumors around the pituitary gland can prevent dangerously high sodium levels (hypernatremia) in the first 24 hours after surgery. High sodium can cause brain bleeding, sei…

This phase 1 trial tests whether the drug tagraxofusp can help prevent relapse in people with certain blood cancers (acute myeloid leukemia, myelodysplastic syndrome, myelofibrosis, or chronic myelomonocytic leukemia) who have recently received a stem cell transplant. Participant…

This study tests the drug anakinra in Chinese patients with two related inflammatory conditions: Systemic Juvenile Idiopathic Arthritis (SJIA) in children and Adult-Onset Still's Disease (AOSD) in adults. Participants receive a daily injection under the skin for 48 weeks. The goa…

This study follows 300 people who receive a hip replacement using either the Vivacit-E or Longevity liner, both made of a special plastic designed to last longer. The goal is to see how well these liners hold up over time, measuring how many are still in place without needing rep…

This phase 3 study tests whether the drug luspatercept can help people with myelofibrosis-related anemia become independent of red blood cell transfusions. Participants are adults with myelofibrosis who are already taking a JAK inhibitor and need regular transfusions. The study c…

This study investigates whether adding two common drugs—valsartan (for high blood pressure) and celecoxib (for arthritis pain)—to standard metformin therapy can improve blood sugar control in people with type 2 diabetes. The trial enrolls adults with obesity, high blood pressure,…

This trial tests whether custom-made zirconia crowns hold up better than prefabricated ones in children's first permanent molars. Fifty children with badly decayed or damaged molars will receive one type of crown, and researchers will track retention, chipping, gum health, and fi…

This trial tests whether adding two drugs—vorinostat and low-dose azacitidine—after a stem cell transplant can help prevent relapse in children with certain myeloid cancers. The study includes children aged 1 to 21 with acute myeloid leukemia or related conditions. Researchers ar…

This study tests whether a home exercise program using a blood pressure cuff to partially restrict blood flow can help people regain leg muscle strength and walking ability after a total knee replacement. Participants will do light exercises three times a week for ten weeks. The …

This study investigates whether injecting Botox a few days before modified lip repositioning surgery helps prevent the return of a gummy smile (excessive gum display when smiling) within one year. Twenty adults with a gummy smile and hyperactive upper lip will be enrolled. The tr…

This study tests a new treatment called NXC-201 CAR-T for people with AL amyloidosis, a rare disease where abnormal proteins build up in organs. The therapy uses a patient's own immune cells, modified to target and destroy the cells producing these proteins. The trial is open to …

This trial tests whether a custom-made plastic implant (ultra-high molecular weight polyethylene) works better than a standard titanium implant for people with chronic jaw dislocation. Participants have a jaw that repeatedly dislocates and has not improved with conservative treat…

This phase 2b trial tests whether adding ALXN2220 to eplontersen works better than eplontersen alone for adults with transthyretin amyloid cardiomyopathy (ATTR-CM), a condition where abnormal proteins build up in the heart. About 326 participants will receive either the combinati…

This trial investigates whether adding dry needling to manual therapy helps people with myofascial headache. Participants receive either manual therapy alone or manual therapy plus dry needling over four sessions. The study measures changes in headache-related disability, neck fu…

This study tests a program called PIXI that coaches parents of infants diagnosed with rare neurogenetic disorders (such as Fragile X, Angelman, or Down syndrome) during the first year of life. The program combines education about the disorder, guided parent-child interaction acti…

This phase 2 trial tests whether adding lab-grown umbilical cord blood cells (dilanubicel) to a standard cord blood transplant helps people with blood cancers like leukemia recover their blood and immune cells faster. Participants receive chemotherapy and radiation to prepare the…

This trial tests whether injections of platelet-rich fibrin (iPRF), made from a patient's own blood, can reduce pain and improve jaw function in people with mild to moderate temporomandibular joint (TMJ) degeneration. Forty-two adults with TMJ arthritis or osteoarthritis will rec…

This phase 2 trial tests an oral drug called venglustat, given alongside the standard enzyme therapy Cerezyme, in adults with Gaucher disease type 3 (a rare genetic disorder affecting the body and brain). The study has four parts: first, it checks spinal fluid biomarkers to disti…

This study tests a combination of two drugs, venetoclax and dexamethasone, in people with a rare blood disorder called AL amyloidosis that has come back or not improved after treatment. The trial includes 53 adults with a specific genetic marker (t(11;14)). The goal is to find th…

This study compares two types of shoulder replacement surgery—Total Shoulder Arthroplasty (TSA) and Reverse Total Shoulder Arthroplasty (RTSA)—in people aged 65 and older with advanced shoulder osteoarthritis. Participants are randomly assigned to one of the two procedures. The g…

This study looks at a new rehabilitation approach in Austria that adds work-specific exercises to standard medical rehab for people with musculoskeletal conditions like back pain. Researchers will follow two groups: one that gets a three-week work-focused program right away, and …

This study compares two types of prefabricated crowns—zirconia and Bioflx—for restoring decayed or discolored front baby teeth in children aged 3 to 5. Each child receives one crown type, and researchers track gum health, plaque buildup, wear on the opposite tooth, crown retentio…

This trial compares two speech therapy approaches for Cantonese-speaking children and teens aged 4 to 17 who have cleft palate with or without cleft lip. One method focuses on practicing individual sounds, while the other targets the overall sound system. The goal is to see which…

This study compares four types of tooth fillings for cavities on the sides of back teeth. Three of the fillings release minerals like calcium and phosphate, which may help repair the tooth and prevent further decay. The fourth is a standard bulk-fill filling used for comparison. …

This trial investigates whether intravenous infusions of tiny particles (extracellular vesicles) from heart progenitor cells can safely improve heart function in people with severe dilated cardiomyopathy and heart failure. Participants receive three infusions and are monitored fo…

This study tests whether a short, standardized 4-minute heart-healthy talk is as effective as a full 60-minute personalized session with a dietitian for lowering LDL cholesterol and improving diet. Participants are adults aged 30–80 with rheumatoid arthritis, psoriatic arthritis,…

This study looks at whether the timing of follow-up exams after non-surgical gum treatment affects how well the gums heal. Researchers will compare re-evaluations done at 3-4 months, 6-8 months, and 12 months after treatment. The goal is to see which timing leads to the most clos…

This study tests a new heat-resistant calcium silicate-based sealer used during root canals in people with infected tooth roots (apical periodontitis). The sealer is applied with different filling techniques to see if it improves bone healing and reduces pain after treatment. Par…

This study tests a device called the Zimmer Biomet Tether System, which is surgically placed along the spine to correct curvature in children with scoliosis. Unlike traditional spinal fusion, which permanently joins vertebrae, this tethering approach aims to guide growth while pr…

This early-stage trial tests an experimental oral drug called GB3226 in adults with acute myeloid leukemia (AML) that has come back or not responded to treatment. The drug works by blocking two pathways that help leukemia cells grow. The study aims to find a safe dose and check f…

This study tests whether taking a 7-day course of oral antibiotics after hip or knee replacement surgery can prevent joint infections in patients at higher risk due to conditions like obesity, diabetes, or autoimmune disease. About 4,600 participants will receive one of three ant…

This study evaluates a free, student-run occupational therapy clinic for uninsured or under-insured adults with spinal cord injury or disease. Participants attend group sessions and one-on-one therapy covering bowel/bladder management, community mobility, and advocacy. Researcher…

This phase I trial tests the safety of adding ruxolitinib to a standard combination of dasatinib and dexamethasone for adults aged 40 and older with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). The study starts with a low dose of ruxoli…

This study tests whether combining spinal cord stimulation with electrical muscle stimulation can improve cough strength in people who recently had a spinal cord injury. Participants will receive either real or sham stimulation during cough training sessions over several weeks. T…

This trial investigates how different amounts of robotic gait training using an exoskeleton, combined with brain stimulation, affect walking ability in people with spinal cord injury. Participants with motor incomplete injuries will train during inpatient and outpatient rehab. Th…

This trial tests whether adding a radioactive antibody (90Y-DOTA-anti-CD25 basiliximab) to standard chemotherapy and targeted radiation can better prepare the bone marrow for a stem cell transplant in people with high-risk acute leukemia or myelodysplastic syndrome. The antibody …

This study tests whether eating dried plums (prunes) every day for a year can improve bone density and strength in postmenopausal women with low bone mass. Participants eat either 6 or 12 dried plums daily, plus calcium and vitamin D supplements. Researchers measure changes in bo…

This study tests whether 3D-printed composite resin fillings work as well as semi-direct composite resin fillings for cavities or damaged back teeth. About 60 adults aged 25 to 40 who need two similar fillings will get one of each type. Researchers will check for cracks, wear, an…

This study tests a surgical technique to restore the natural curve (lordosis) of the lower spine in people who have had a previous spinal fusion that failed or caused ongoing pain. The procedure is done through the same incision used in the prior surgery. Researchers will measure…

This study tests the long-term safety and effectiveness of an experimental drug called BBP-418 (ribitol) in people with limb-girdle muscular dystrophy type 2I/R9, a rare genetic muscle-weakening disease. Participants who completed a previous study will take BBP-418 orally twice d…

This study tests a new approach for people receiving a stem cell transplant from a partially matched family donor. The donor's immune cells (T cells) are modified in the lab to include a 'suicide gene' that can be activated by a drug if the cells attack the patient's body, causin…

This study compares two types of implants used in spinal fusion surgery: 3D-printed cages and titanium-coated cages. The goal is to see which leads to better bone fusion and less disability for patients with herniated discs or degenerative spine disease. About 78 adults undergoin…

This trial tests whether specially modified T cells from a partially matched donor can help patients recover their immune system faster after a stem cell transplant. The T cells are engineered with a 'suicide gene' that allows doctors to destroy them if they cause graft-versus-ho…

This study tests a precise radiation method called total marrow and lymphoid irradiation (TMLI) given with two chemotherapy drugs (etoposide and cyclophosphamide) before a donor stem cell transplant. The goal is to safely deliver higher radiation doses to the bone marrow to wipe …

This study tests a single dose of PBGM01, a gene therapy delivered directly into the fluid around the brain and spinal cord, in children with GM1 gangliosidosis. The therapy uses a harmless virus to carry a working copy of the GLB1 gene, which is missing or faulty in these patien…

This study tests two methods of placing a bulk-fill composite filling material in cavities on the chewing surfaces of back teeth. One method places the material all at once, while the other builds it up in thin layers. Researchers will check how well each method holds up over tim…

This trial investigates the best way to treat children with acute myeloid leukaemia (AML) by comparing different chemotherapy drugs and doses. It tests whether adding up to three doses of the targeted drug gemtuzumab ozogamicin to standard chemo is safe and effective. The study a…

This study tests whether a robotic exoskeleton called ReWalk can help people with complete spinal cord injury below T4 walk and improve their health. Fifty participants will either use the exoskeleton or receive standard physical therapy. The goal is to see if the device improves…

This study follows 16 infants aged 6 months or younger with infantile-onset Pompe disease, a rare genetic disorder that weakens muscles and breathing. All receive alglucosidase alfa (Myozyme) as part of their routine care. Researchers track how many survive without needing a brea…

This phase 3 trial compares a two-drug combination (pevonedistat plus azacitidine) against azacitidine alone in 302 older or unfit adults newly diagnosed with acute myeloid leukemia (AML) who cannot have standard intensive chemotherapy. The main goal is to see if the combination …

This study tests whether giving people different taste-based advice helps them reduce their free sugar intake to less than 5% of daily energy. Participants are adults in southern England who consume more than 10% of their energy from free sugars. They are randomly assigned to adv…

This study tests an experimental drug called LY2784544 in people with three types of blood cancers known as myeloproliferative neoplasms: polycythemia vera, essential thrombocythemia, and myelofibrosis. The trial enrolls patients who have not responded to, cannot tolerate, or hav…

This study tests whether adding hyaluronic acid to a platelet-rich fibrin membrane improves the treatment of receding gums. Thirty adults with a specific type of gum recession will receive either the PRF membrane alone or with hyaluronic acid, alongside a surgical flap procedure.…

This study tests whether acetyl L-carnitine, a dietary supplement, can help reduce pain, inflammation, and improve blood sugar control in obese, diabetic, postmenopausal women with osteoarthritis. One hundred women will take either the supplement or a placebo for 12 weeks, alongs…

This study tests dalbavancin, a long-acting antibiotic given as a few shots over two months, for infections that occur after hip or knee replacement surgery. The standard treatment requires 12 weeks of daily antibiotics, which can be hard to tolerate and complete. The trial inclu…

This study follows 94 people who received the FDA-approved H3 total ankle replacement for arthritis. Researchers will track serious device-related problems and how well the ankle works over 2 to 5 years. The goal is to confirm the device's safety and effectiveness in real-world u…

This trial tests a fracture liaison service (FLS) — a coordinated care program for people aged 50 and older who have had a hip or spine fracture. The program follows best-practice standards to ensure patients receive bone density tests and appropriate osteoporosis management. Res…

This study tests a stem cell transplant method for people with acquired or inherited bone marrow failure. Donor stem cells are specially processed to remove certain immune cells, which may lower the risk of graft rejection and graft-versus-host disease. The goal is to see if this…

This early-phase trial tests a reduced-intensity stem cell transplant using a half-matched donor and a drug called cyclophosphamide after the transplant to prevent rejection. The goal is to see if this approach is safe enough for patients with advanced myelofibrosis, a serious bo…

This study tests whether switching to avalglucosidase alfa is safe and more effective for people with late-onset Pompe disease whose condition has worsened on the standard treatment, alglucosidase alfa. Participants receive biweekly infusions of the new drug and are monitored for…

This study tests a service designed to help people with osteoporosis take their medications as prescribed. Participants receive education, reminders, and regular follow-up calls. The goal is to see if this support improves medication adherence and reduces fracture risk over 18 mo…

This clinical trial compares three different chemotherapy regimens for young adults (ages 18-65) newly diagnosed with low-risk acute myeloid leukemia (AML). One regimen includes a new drug called lisaftoclax combined with standard chemotherapy drugs. The study aims to see which c…

This study tests three different chemotherapy regimens in 450 young adults (ages 15-65) with intermediate- or high-risk acute myeloid leukemia (AML). All regimens include the experimental drug lisaftoclax plus standard chemotherapies. The main goal is to see which combination lea…

When a tooth is removed, the bone and gum often shrink, making it harder to place a dental implant later. This study tests a new magnesium membrane that is placed over a bone graft in the socket. Unlike standard membranes, it is rigid enough to protect the graft but dissolves on …

This study tests whether injections of platelet-rich plasma (PRP) or stem cells from belly fat can help people with knee osteoarthritis. 160 adults aged 40-70 with mild to moderate knee arthritis will be randomly assigned to get PRP, stem cells, both, or a placebo. Researchers wi…

This study tests a single injection of VIA Disc NP, a processed human disc tissue, for people with long-term lower back pain from degenerated discs. About 121 participants will receive either the injection or a sham procedure. The goal is to see if the injection safely reduces pa…

This study tests a minimally-invasive non-surgical therapy (MINST) for treating gum disease-related bone defects. The approach uses small instruments and magnification to clean deep gum pockets with less tissue damage than traditional surgery. Researchers will measure bone healin…

This phase 2 trial tests a combination of six drugs, called the Beach regimen, in 32 adults with relapsed or refractory acute myeloid leukemia (AML). The goal is to see if this mix can bring about remission and improve survival. Participants receive the drugs in a specific schedu…

This study tests a new dental filling made with coconut nanoparticles for children's baby teeth. Sixty children aged 5 to 9 with cavities will receive either the new coconut filling or a standard glass ionomer filling. Researchers will check the fillings' surface, shape, and how …

This study tests whether a wearable suit that delivers small electrical pulses to leg muscles can improve walking speed in people with incomplete spinal cord injury. Participants first do standard treadmill training, then add the electrical stimulation suit for 20 sessions. The m…

This phase II trial tests two targeted drugs, vemurafenib and cobimetinib, in 24 people with a rare type of brain tumor called papillary craniopharyngioma that has a specific genetic mutation (BRAF V600E). The drugs work by blocking enzymes that help tumor cells grow. The main go…

This study looks at whether lower doses of the chemotherapy drug CPX-351 can help older patients with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) that have come back or not responded to other treatments. The goal is to control the disease while being gentler o…

This phase 2 trial tests an injectable form of methotrexate called FBL-MTX for people with moderate-to-severe rheumatoid arthritis. The drug is designed to deliver methotrexate directly into the body using tiny fat bubbles, which may improve how well it works and reduce side effe…

This study looks at whether adding the drug abaloparatide (Tymlos) to the standard treatment denosumab (Prolia) can improve bone density more than denosumab alone in postmenopausal women with osteoporosis. Seventy women who have already been on denosumab will either continue with…

This study tests whether a surgically implanted device that sends electrical pulses to the spinal cord can help people with spinal cord injury regain voluntary leg movement. Only 2 participants with specific injury levels and MRI evidence of spared nerve fibers will be enrolled. …

This phase 2 trial tests whether eltrombopag, a drug already approved for other blood disorders, can improve blood cell counts in people with low-risk myelodysplastic syndromes (MDS) or chronic myelomonocytic leukemia (CMML) who have a mutation in the TET2 gene. Participants take…

This study tests a combination of a patient's own stem cells and platelet-rich plasma to help heal broken bones that won't mend on their own and to treat knee arthritis. For people needing a knee replacement, doctors use custom 3D-printed guides made from the patient's scans to i…

This early study tests a new device called SINEFIX to repair small rotator cuff tears (up to 2 cm) in 9 adults. The implant is placed during keyhole surgery to reattach the torn tendon to the bone. Researchers will use MRI scans to check if the tendon heals properly and if there …

This trial tests whether adding a healing material made from the patient's own blood (Advanced Platelet-Rich Fibrin, or A-PRF) to standard gum surgery helps cover exposed tooth roots better than surgery alone. Eleven adults with gum recession will receive either the combined trea…

This study compares two treatments for end-stage hip osteoarthritis: total hip replacement surgery and progressive resistance training (strength exercises). About 109 adults aged 50 and older with severe hip arthritis will be randomly assigned to one of the two treatments. The ma…

This study looks at whether choosing stem cell donors based on certain genes (KIR) in addition to standard matching can reduce the chance of leukemia returning after a bone marrow transplant. About 511 people with acute myeloid leukemia (AML) are taking part. Doctors will test do…

This study tests whether new plastic-like PEEK crowns work as well as standard metal crowns for children's back teeth after a common nerve treatment (pulpotomy). Sixty kids aged 5-9 got one PEEK crown and one metal crown on opposite sides of their mouth. Researchers checked gum h…

This study tests whether simple text messages and online activities can encourage people with Type 2 Diabetes to get more preventive dental care, like cleanings, instead of waiting for expensive treatments. Researchers will track dental insurance claims from 10,000 adults over 18…

This study looks at whether giving people with PTSD a personalized mix of gut bacteria (called pharmabiotics) can help their mental health. The researchers will track changes in PTSD symptoms, anxiety, depression, and thinking skills over 14 days. The goal is to see if fixing the…

This study tests whether adding the drug itacitinib to the usual two-drug regimen (cyclophosphamide and tacrolimus) can better prevent graft-versus-host disease (GVHD) in people receiving stem cell transplants for blood cancers. GVHD is a serious complication where donor cells at…

This study tests a stem cell transplant from a matched unrelated donor for people with advanced blood cancers or blood disorders. Patients get chemotherapy and radiation before the transplant to prepare their body, then take drugs to prevent the donor cells from attacking their o…

This study tests whether a graft made from a person's own extracted tooth, with or without low-level laser therapy, helps regrow jawbone after a tooth is pulled. About 21 healthy adults who need at least two back teeth removed and later replaced with implants will take part. The …

This study tests whether adding a special nano-gel (nano-hydroxyapatite) to a deep-cleaning gum treatment helps heal deep gum pockets better than cleaning alone. About 28 adults with advanced gum disease will be randomly assigned to get either the cleaning plus gel or just the cl…

This pilot study tests a fludarabine-based drug regimen to prepare children with bone marrow failure syndromes for a bone marrow transplant from a matched sibling donor. The goal is to help the donor cells successfully take root while reducing serious side effects. The study incl…

This study aimed to see if giving special immune cells (γδ T cells) after a stem cell transplant could help prevent leukemia from coming back in high-risk patients. It was planned for adults aged 18-65 with acute myeloid leukemia. However, the study was withdrawn before any parti…

This study tests a new device that combines two heart therapies: one to strengthen heartbeats and another to stop dangerous rhythms. About 300 adults with heart failure and a weak heart pump will get the device. Researchers will check if it safely converts life-threatening heart …

This study tests whether a special clot made from a patient's own bone marrow can help spine bones heal together faster and more reliably after spinal fusion surgery. The trial involves 96 adults with degenerative spine disease. Half will receive the standard bone graft, and the …

This study looks at whether 10 weeks of regular exercise (on land or in water) can lower blood sugar and blood pressure in people aged 60 and older who have several health conditions like diabetes, high blood pressure, and arthritis. 63 volunteers will be split into two exercise …

This study tests whether a toothpaste with stannous fluoride works better than regular fluoride toothpaste at reducing dental plaque and gum inflammation (gingivitis). About 85 adults with mild to moderate gum disease will brush twice daily for 6 months. Dentists will measure pla…

This study tests whether adding cabergoline to osilodrostat works better than osilodrostat alone for controlling Cushing's disease. About 50 adults with active Cushing's disease will receive either the combination or the single drug. The goal is to see if the combo can lower cort…

This trial tests a 12-month lifestyle medicine program for 1000 adults with obesity and related conditions like diabetes or high blood pressure. Participants get regular visits with a dietitian and a doctor, plus optional behavioral health support. The goal is to see if the progr…

This early-stage trial tests two new targeted drugs (AG-120 and AG-221) given alongside standard chemotherapy for people with a specific genetic form of acute myeloid leukemia (AML). The study includes about 153 adults with newly diagnosed AML that has an IDH1 or IDH2 mutation. T…

This phase 2 trial tests two oral drugs, ribociclib and everolimus, in people with advanced dedifferentiated liposarcoma or leiomyosarcoma who have had at least one prior treatment. The goal is to see if the combination can stop or slow tumor growth. About 48 participants will ta…

This Mayo Clinic study tests a new 3D MRI sequence called oZTEo, enhanced with deep learning, to detect bone erosions in the hands of people with inflammatory arthritis. The goal is to see if this advanced scan finds erosions better than standard MRI or X-rays. The study will enr…

This study evaluates a portable, strap-fixed device for measuring ankle strength in people with weakness caused by lumbar disc herniation. It compares the device's readings to a standard laboratory machine in healthy volunteers, then tests it in patients to see if it reliably cap…

This trial is testing a new imaging tracer called FLT, which is used with a PET scan to measure how fast tumors are growing. The study includes people with various cancers or those awaiting a biopsy for a suspicious mass. The goal is to see if FLT PET imaging can help find and di…

This study enrolls about 4,000 adults aged 60 and older with heart failure who are at high risk for ATTR amyloidosis, a rare disease that stiffens the heart. Doctors receive special training on how to spot and diagnose the condition using standard tests. The goal is to see if thi…

This trial tests whether an AI tool called DeepBMD can identify people at high risk for osteoporosis using CT scans they've already had for other reasons. Researchers will compare the AI's findings with the standard bone density test (DXA) to see if it's accurate. If it works, th…

This study investigates how well different imaging methods—ultrasound, CT, and MRI—can identify the cause of neck swellings in children. Researchers will compare imaging results with the final diagnosis from biopsy, lab tests, or follow-up. The goal is to see if imaging can relia…

This study is testing whether artificial intelligence can detect transthyretin amyloid cardiomyopathy (ATTR-CM), a serious and often underdiagnosed heart condition, earlier than usual. Researchers will use AI algorithms to analyze routine ECGs and heart ultrasounds from up to 1.5…

This trial tests whether an artificial intelligence model can accurately diagnose gingivitis — early gum disease — by analyzing digital photographs and X-rays. Researchers will compare the AI's assessments to those of dental experts. If it works, this approach could make gum dise…

This study tests whether a radioactive tracer called 124I-evuzamitide can detect amyloid deposits in the heart and elsewhere in people aged 60 and older who have lumbar spinal stenosis or carpal tunnel syndrome. Participants will receive a single dose of the tracer and undergo a …

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This study tests a 3D body scanner called NSite to see if it can reliably monitor scoliosis in teenagers. Thirteen teens with scoliosis will be scanned by three different users to check if the results are consistent. If it works, this device could offer a radiation-free way to tr…

This study tests a new ultrasound device that measures bone properties in the lower leg to predict fracture risk in adults over 55. It aims to see if it works as well as or better than standard DXA scans, without using radiation. Researchers will follow 1,600 participants for thr…

This study is testing whether artificial intelligence (AI) can accurately diagnose periodontitis (severe gum disease) and monitor gum inflammation using dental records and X-rays. Researchers will develop and validate AI models using data from 900 patients across multiple hospita…

This trial tests whether an educational program on sustainable diet and breastfeeding, given before delivery, can increase the number of mothers who exclusively breastfeed for up to six months. The study includes 429 pregnant women and also measures the environmental impact of di…

This study tests whether a dedicated care coordinator can help people with psoriasis or psoriatic arthritis reduce their risk of heart disease. About 520 adults aged 40-75 who do not already take cholesterol medication will receive support to manage risk factors like high cholest…

This trial tests whether a bioactive resin containing S-PRG filler, used as attachment material for clear orthodontic aligners, can prevent white spot lesions (early decay) on tooth enamel. Fifty healthy young adults with mild to moderate crowding will be randomly assigned to rec…

This study tests whether a topical 10% povidone-iodine solution can prevent white spot lesions on the front teeth of teens undergoing fixed orthodontic treatment. Healthy participants aged 10 to 17 will receive either the iodine solution or a placebo applied to all tooth surfaces…

This study tests a program called PREVENT designed to reduce hip fractures in long-term care homes. The program uses a risk calculator based on residents' health records to identify those at high risk, then trains healthcare staff on the latest fracture prevention recommendations…

This study investigates whether a painless fluorescent light exam can help find early warning signs of oral cancer in adults. Participants complete a health questionnaire and receive a standard oral exam plus a fluorescence scan. The goal is to see if this simple, non-invasive to…

This trial investigates whether a daily effervescent supplement containing calcium, magnesium, and citrate can prevent bone loss, magnesium deficiency, and kidney damage in adults who take proton pump inhibitors (PPIs) long-term for conditions like heartburn or GERD. Participants…

This trial compares two gentle manual therapies—the Emmett Technique and Bowen Therapy—for people with upper trapezius myofascial pain syndrome, a common cause of neck pain and stiffness. About 46 adults aged 18 to 45 with chronic neck pain will be randomly assigned to receive on…

This study tests whether a daily capsule containing a heat-killed probiotic (LDL557) can improve joint discomfort and inflammation in 100 older adults with early knee or hip arthritis. Participants take either the probiotic or a placebo for a period, and researchers measure chang…

This study compares two manual therapy techniques—Positional Release Technique and Post Isometric Relaxation—to see which better reduces pain, improves neck movement, and eases daily disability in people with tight levator scapulae muscles. About 44 adults aged 25 to 40 with neck…

This study tests two physical therapy techniques for frozen shoulder (adhesive capsulitis). About 42 adults aged 40-60 will receive either Gong's mobilization alone or with an added scapular lift. The goal is to see which method better improves shoulder movement, reduces pain, an…

This study tests whether taking essential amino acid supplements before and after spinal surgery helps adults with spinal deformity recover better. Twenty participants will take either the supplement or a placebo for two weeks before surgery and three months after. Researchers wi…

This study tests whether a 10-week program called Positive Minds, Strong Joints is feasible for Black adults aged 50 and older with knee osteoarthritis. The program combines recommended exercise with mental health strategies to address pain, depression, and anxiety. Researchers w…

This study tests whether transcutaneous spinal cord stimulation (TSCS) — a gentle electrical current applied through the skin — can help veterans with chronic spinal cord injury (SCI) better regulate blood pressure during exercise and cold exposure. Participants will receive both…

This study tests a home monitoring program called LiverWatch for people with advanced liver disease (cirrhosis). Participants get a Fitbit, personalized nutrition advice, and weekly check-ins to boost activity and manage symptoms. The goal is to see if this approach improves qual…

This study tests whether a specific ultrasound-guided nerve block can reduce pain after elective lower back surgery better than the usual method of injecting pain medicine into the wound. Adults aged 18-65 undergoing surgery for conditions like a herniated disc or spinal stenosis…

This study follows 166 people aged 45 and older who received the Superion IDS implant for lumbar spinal stenosis, a condition that narrows the spine and causes leg pain. The implant is designed to limit certain movements that worsen symptoms. Researchers are checking if patients …

This study tests two treatments for tennis elbow (lateral epicondylitis) in 60 adults aged 18-65. One group gets ultrasound-guided dry needling, the other gets shock wave therapy, both once a week for five weeks. Everyone also does a home exercise program. The goal is to see whic…

This phase 3 trial tests whether aficamten, an oral drug, can improve quality of life and exercise capacity in 500 adults with symptomatic non-obstructive hypertrophic cardiomyopathy, a heart condition that makes the heart muscle thick and stiff. Participants receive either afica…

This study tests two standard methods—manual scraping with a hand tool or using a small rotating bur—to clean out unhealthy tissue from a tooth socket after extraction. About 60 adults with long-term tooth infections will be randomly assigned to one method, then all receive a bon…

This trial tests whether a small device that stimulates the vagus nerve through the ear can improve quality of life for people with long COVID who also meet the criteria for ME/CFS (chronic fatigue syndrome). Participants will use the device daily for six weeks, and researchers w…

This phase II trial is testing whether an experimental lotion called ASKC200 can reduce pain in people with knee osteoarthritis. About 175 adults aged 40 to 80 with knee pain lasting at least six months will be randomly assigned to receive one of two strengths of ASKC200, a stand…

This study is testing a robotic lower-limb exoskeleton combined with functional electrical stimulation (FES) to help people with conditions like spinal cord injury, brain injury, or multiple sclerosis improve their walking. The device provides robotic support and electrical stimu…

This trial is testing whether watching educational videos before minimally invasive gynecologic surgery can lower patient anxiety. Participants are randomly assigned to either watch the videos or receive standard counseling alone. The study measures anxiety and preparedness throu…

This study looks at whether adding a low-dose dexmedetomidine infusion to standard pain management can lower the amount of narcotics needed and reduce side effects like nausea and itching in teenagers having posterior spinal fusion for scoliosis. About 160 adolescents with idiopa…

This trial investigates whether adding a gentle hip ligament stretch to a foot joint mobilization can reduce pain and improve knee function in people with patellofemoral pain syndrome (PFPS), a common cause of front knee pain. Eighty adults with PFPS will receive either standard …

This trial tests whether a rehabilitation program that exercises the entire leg — from foot to hip — can improve balance, reduce pain, and restore function better than standard tendon-focused exercises in people with chronic Achilles tendinopathy. Fifty adults aged 18 to 45 with …

This phase 3 trial tests whether an 800 mg modified-release ibuprofen tablet can reduce chronic knee pain from osteoarthritis better than a placebo. About 500 adults with knee osteoarthritis will take either the long-acting ibuprofen or a placebo daily for 12 weeks. Researchers w…

This trial tests whether suzetrigine (Journavx), a newly approved non-opioid pain medication, can effectively control pain after thumb basal joint replacement surgery. One hundred adults aged 40 to 80 will receive suzetrigine plus acetaminophen for five days after surgery, and th…

This study tests whether a home-based exercise program guided by online videos can improve symptoms and quality of life in people with axial spondyloarthritis, a type of arthritis affecting the spine. Participants follow video exercises for 3 months, and researchers compare their…

This trial compares five different motion patterns used in root canal treatment to see which one causes the least pain afterward. Adults aged 18 to 65 with asymptomatic root canal needs will be randomly assigned to one of the five motion types. Pain levels and inflammatory marker…

This trial tests whether adding blood flow restriction (BFR) training to standard rehabilitation helps adults with chronic Achilles tendinopathy recover better. BFR uses a cuff to partially restrict blood flow during low-load exercises, aiming to build strength with less tendon s…

This trial tests whether a special remineralizing gum can improve oral health in adults who have bad breath, sensitive teeth, or gum discomfort. Participants chew one piece of gum daily for 30 days and report changes in breath freshness, tooth sensitivity, and gum comfort. The st…

This study tests a new combination of nerve blocks for elderly patients (65 and older) having surgery for a broken shoulder. The goal is to see if the new approach provides better pain relief during surgery and lowers the risk of temporary diaphragm paralysis, which can cause bre…

This study compares three treatments for shoulder impingement and carpal tunnel syndrome: ultrasound-guided corticosteroid injections, standard injections guided by touch, and oral pain medication. Researchers want to see which approach provides the best long-term pain relief, im…

This pilot study tests the drug ruxolitinib in people with advanced non-small cell lung cancer who are experiencing cancer cachexia—unintended weight loss and muscle wasting. The main goal is to check for side effects and see how the drug affects body signals related to appetite …

This trial tests a minimally invasive surgery for cervical spinal stenosis, a condition where the spinal canal narrows and presses on the spinal cord. Instead of the standard approach that uses metal screws and rods, surgeons will only remove the tissue causing the compression th…

This study tests whether a non-invasive electrical stimulation device placed on the skin over the spine can help veterans with spinal cord injury improve blood pressure, exercise capacity, and body temperature regulation. Twenty veterans with injuries between the neck and upper b…

This study compares two 12-week exercise programs—eccentric training and heavy-slow resistance training—in 30 adults aged 18–50 with patellar tendinopathy (knee pain lasting over 3 months). Researchers measure changes in tendon thickness, stiffness, strength, and pain to see whic…

This pilot study tests a WeChat-based program that provides daily mental health check-ins and tailored coping strategies for people with ankylosing spondylitis who also have mild-to-moderate depression or anxiety. Thirty-six adults will be split into two groups: one receives the …

This study compares three non-surgical treatments—exercise therapy, shockwave therapy, and ultrasound-guided irrigation—against a wait-and-see approach for people with painful calcium deposits in the shoulder. About 116 participants with confirmed calcific tendinopathy will be ra…

This study compares two non-invasive treatments—extracorporeal shock wave therapy and high-intensity laser therapy—for chronic plantar fasciitis, a common cause of heel pain. Sixty adults will receive one of the treatments plus standard physical therapy. Researchers will measure …

This study tests whether using a portable light device (photobiomodulation) at home for 8 minutes daily can reduce pain, root damage, and improve gum health in adults getting braces. Fifty patients aged 18–35 who need premolar extractions will use the device alongside standard br…

This study tests whether two devices, used one after the other, can reduce pain and disability from temporomandibular joint (TMJ) disorders. Adults aged 22 and older with TMJ pain will receive four treatment sessions and be followed for three months. Researchers will measure chan…

This early-stage trial tests an experimental drug called RAB001, given as an injection into the knee joint, for people with knee osteoarthritis. The study includes 60 participants aged 40 to 75 who have persistent knee pain despite conservative treatments. Researchers are primari…

This study combines artificial intelligence with ultrasound imaging to better understand and treat frozen shoulder (adhesive capsulitis). Researchers will compare three different ultrasound-guided injection techniques in 192 participants to see which one best reduces pain and imp…

This study tests a wearable device called TracPatch that sticks to the shin after total knee replacement surgery. The patch tracks knee motion, temperature, and steps for six weeks, sending data to doctors. Researchers want to see if this real-time monitoring helps patients regai…

This study aimed to see if adding a mild electrical current to the brain (transcranial stimulation) during shoulder strengthening exercises helps people with subacromial pain syndrome more than exercise alone. Participants would have done 8 weeks of shoulder exercises while weari…

This study planned to test whether a nerve block in the cheek area could reduce the need for morphine after cleft palate repair in children aged 5 months to 12 years. The experimental group would have received the nerve block, while the control group would not. However, the study…

This study compares two manual therapy techniques—Reciprocal Inhibition and Passive PNF Stretching—for people with chronic neck pain from cervical spondylitis. Sixty participants will receive 12 sessions over 4 weeks. Researchers will measure pain, disability, and neck movement t…

This study tests whether giving people with rotator cuff shoulder pain regular updates on their progress (like pain scores and strength) helps them recover better. 56 adults aged 18–35 will either get standard rehab or standard rehab plus these progress updates. The goal is to se…

This pilot study explores whether a 7-day fast followed by 11 weeks of a plant-based diet can reduce skin and joint symptoms in people with psoriasis and psoriatic arthritis. Researchers will also look at changes in gut bacteria and overall quality of life. The study involves 30 …

This study tests whether an AI-powered reflection tool can help patients with chronic orthopedic conditions (like arthritis or carpal tunnel) think more flexibly about their symptoms and feel more trust in their doctor. About 150 adults will be randomly assigned to either use the…

This study tests whether applying an ice pack to the lower abdomen after vNOTES hysterectomy can lower pain and reduce the need for painkillers. 122 women having surgery for benign conditions will be randomly assigned to receive either standard care or standard care plus ice pack…

This study looks at whether using a blood flow restriction cuff during physical therapy can help people with tennis elbow feel less pain and recover faster. The trial plans to enroll 250 adults aged 18 to 65 with confirmed tennis elbow. Participants will either receive standard p…

This study tests whether a 6-week, caregiver-assisted breathing program done at home with remote coaching is practical and helpful for children with Duchenne muscular dystrophy. Twelve children will do breathing exercises, airway clearance, and relaxation techniques at least 5 ti…

This study was designed to compare two types of nerve-blocking procedures for people with long-term knee pain from osteoarthritis. The goal was to see if targeting six nerves works better than the usual three nerves for reducing pain and improving daily function. The trial was wi…

This study looks at whether time-restricted eating (a form of intermittent fasting) is a practical way for veterans with spinal cord injury and obesity to lose weight. Fifteen veterans with paraplegia will try eating all their daily calories within a set window of time for 6 week…

This study tests whether doing physical therapy from home (via video calls or a mix of home and clinic visits) works as well as going to a clinic in person for young adults with patellofemoral pain syndrome, a common cause of front knee pain. About 42 people aged 18 to 35 will be…

This study tests whether using cold or laser-activated fluids during a root canal can reduce pain and kill more bacteria than standard treatment. Sixty adults with an infected lower molar will receive one of four rinses: room-temperature, cold, heated, or laser-activated sodium h…

This study compares four different rinsing tools used after root canal treatment to see which one reduces pain the most. Fifty-two adults with an infected lower back tooth will be randomly assigned to one of four groups. They will rate their pain at several times over two days an…

This study tests whether robotic-assisted walking training (using a device called Lokomat) can improve balance and walking smoothness in people with incomplete spinal cord injury. Thirty participants will be randomly assigned to either robotic training or standard physiotherapy. …

This study compares biofeedback training to lifestyle changes (like special positions and massage) for women with dyssynergic defecation, a condition where pelvic floor muscles don't relax properly during bowel movements. About 58 women aged 35-65 with chronic constipation will p…

This study explores whether a supervised, circuit-based resistance training program can help glioblastoma patients maintain muscle mass and perform daily tasks more easily. Researchers will enroll 24 adults with glioblastoma who are currently on treatment. Participants will exerc…

This study compares two treatments for plantar fasciitis, a common cause of heel pain. About 56 adults with heel pain for at least 6 weeks will receive either instrument-assisted soft tissue mobilization or manual massage. Researchers will measure pain, daily function, and walkin…

This study looks at two different ways to manage pain after lower back surgery without relying on drugs. About 267 adults will be randomly assigned to either standard care or an enriched pain management plan. The goal is to see which approach better reduces pain and helps people …

This study tests whether dronabinol, a drug made from cannabis, can help control pain after knee arthroscopy. About 30 adults will take part to see if it reduces the need for opioid painkillers and causes fewer side effects. The results will help decide if larger studies are need…

This study tests whether releasing a tight pectoralis minor muscle (a chest muscle) can improve shoulder function and reduce pain in people with shoulder impingement syndrome. Sixty adults aged 40–60 with chronic shoulder pain will receive either standard physical therapy alone o…

This small pilot study tests two different stitching techniques during gum surgery to cover exposed tooth roots caused by gum recession. Seven healthy adults with multiple areas of gum recession will receive both techniques in different parts of their mouth. The goal is to see wh…

This study aimed to compare different treatments—like mouthguards, jaw exercises, and anti-inflammatory drugs—for jaw muscle or joint pain in children aged 7 to 14. The goal was to see which works best and if any affect jaw growth. However, the study was withdrawn before enrollin…

This study tests whether a specific type of exercise called eccentric contraction (lengthening muscles under tension) can help people with shoulder pain syndrome. Sixty adults aged 18-70 with rotator cuff tendinitis will do either eccentric exercises plus standard therapy or stan…

This study tests whether adding yellow or green light therapy to standard care (ice and exercises) can reduce pain and improve knee function in 60 athletes with jumper's knee. Participants will receive either yellow light, green light, or standard care alone. The goal is to see i…

This study looks at whether adding desensitization exercises to the usual hand rehab program can help rheumatoid arthritis patients who have central sensitization—a condition where the nervous system is extra sensitive to pain. About 81 adults with mild-to-moderate RA will be spl…

This study compares two knee replacement systems, Persona and NexGen, in 332 people with knee osteoarthritis. Participants receive one of the two implants during surgery. Researchers track pain, function, and quality of life for up to two years to see if one system leads to bette…

This study tracks 80 adults with different smell disorders (like total loss, partial loss, or distorted smell) plus healthy volunteers over one year. Researchers use brain scans, smell tests, and questionnaires to see how the brain changes and how smell loss impacts mood and dail…

This study from the University of Pittsburgh is looking at how well people recover after total knee replacement surgery. It compares two types of surgery: one done with a robot's help and one done by hand. Researchers will follow 30 people who are already scheduled for knee repla…

This study is developing a digital twin—a virtual model of the heart and blood vessels—to better understand and manage hypertrophic cardiomyopathy (HCM), a condition where the heart muscle thickens. Researchers will gather detailed health data from 2500 people with HCM or the gen…

This early-stage study will check if two different tablet forms of the drug HRS-1893 are processed the same way in the body. Thirty-six healthy adults will take both versions and have blood tests to measure drug levels. The goal is to see if the two formulations are equivalent, n…

This study looks at people and families who have a high risk of cancer to learn what genes and environmental factors might increase that risk. Over 5,000 participants are followed over time with questionnaires, medical records, and optional genetic testing. No treatment is given,…

This study looks at how well the heart, lungs, and muscles work together in people who have had a stem cell transplant. Researchers want to find out why transplant survivors have a higher risk of heart disease. About 350 adults with blood cancers will be followed for two years af…

This study is investigating how common muscle loss, known as sarcopenia, is in people with blood cancers like leukemia, lymphoma, and myeloma. Researchers will measure body composition using DXA scans and track hospital stays, disease progression, and survival. The goal is to see…

This study tests whether a special website and video coaching for parents can help children aged 6-12 who had leukemia or lymphoma improve their learning and school performance. Many children survive these cancers but may struggle with memory, attention, and thinking due to treat…

This study aims to find genetic changes that may cause sporadic chordoma, a rare bone cancer. Researchers will collect saliva and medical records from 188 patients across the U.S. and Canada who are the only ones in their family with chordoma. No treatment is given; the goal is t…

This study is collecting blood, bone marrow, and tissue samples from 5,000 people with blood cancers like leukemia and lymphoma. Researchers will analyze the samples to find genetic abnormalities that cause cancer cells to grow. The goal is to understand why these cancers develop…

This study follows adults with pathogenic variants in the anoctamin 5 gene, which causes a form of limb-girdle muscular dystrophy. Over three years, researchers will use whole-body MRI to measure changes in muscle fat content, and questionnaires to track fatigue and quality of li…

This study aims to describe the pattern of muscle involvement in people with limb girdle muscular dystrophy caused by mutations in the anoctamin 5 gene. Researchers will collect and analyze MRI scans from 200 participants to see which muscles are affected and how much fat replace…

This study explores whether people with plantar fasciitis—a common cause of heel pain—show differences in spinal posture, balance, and core muscle endurance compared to healthy individuals. Researchers will measure these factors in adults aged 18 to 50 with and without the condit…

This study looks back at 10 years of medical records from a scoliosis referral center to see how frequently adults with scoliosis who had surgery also develop restrictive breathing problems or signs of pulmonary hypertension on echocardiography. By analyzing data from 174 patient…

This study follows 60 adults getting hip or knee replacement to track their sleep before and up to 6 months after surgery. Participants use a special device and app to measure sleep quality, pain, and recovery. The goal is to learn when sleep returns to normal so doctors can give…

This study tests two different drug combinations in people with advanced colorectal, pancreatic, or leiomyosarcoma cancers that have not responded to standard treatments. Participants receive either olaparib plus durvalumab or cediranib plus durvalumab. The main goal is to unders…

This study aims to better understand fatigue by comparing people who have felt tired for more than a month with those who are not fatigued. Researchers will use questionnaires, physical tests, and optional brain scans to identify different types of fatigue. The goal is to gather …

This study is testing a new physical therapy protocol for people over 50 who have had arthroscopic rotator cuff surgery. Researchers will track shoulder function, pain levels, and sleep quality over the recovery period. The goal is to gather better evidence on what helps patients…

This study collects blood, bone marrow, urine, and tissue samples from up to 6,000 people with solid tumors, blood cancers, or non-cancerous blood disorders, as well as from their healthy family members who are stem cell donors. The samples are stored and used in research to bett…

This study evaluates whether a single dose of TQ05105, a JAK inhibitor being developed for myelofibrosis, affects the heart's electrical activity (QT interval) in healthy Chinese adults. Sixty participants receive TQ05105, placebo, and moxifloxacin (a positive control) in a cross…

This study follows children aged 6 to 17 with active juvenile enthesitis-related or psoriatic arthritis who are being treated with secukinumab. Researchers will track how long children stay on the drug, how much their symptoms improve, and whether they achieve remission. The goal…

This study looks at whether sensors inside implanted heart devices can warn of worsening heart failure. Researchers will track 500 adults with heart failure or cardiomyopathy who have a Boston Scientific ICD or CRT-D equipped with HeartLogic, Sleep Incline, and Apnea Scan functio…

This study tests a quick, non-invasive brain scan called Magnetic Resonance Fingerprinting (MRF) in children and young adults with acute leukemia. The goal is to see if the scan can detect early brain changes caused by chemotherapy. Participants also take a fun, game-like memory …

This study looks at whether a special type of testing, called leukemia profiling, can help find personalized treatment options for children and young adults up to age 30 with recurrent, refractory, or high-risk leukemias. Researchers analyze the genetic changes in each patient's …

This study is looking at how magnetic resonance imaging (MRI) and spectroscopy can be used to detect and track changes in the muscles of people with facioscapulohumeral muscular dystrophy (FSHD). The goal is to identify reliable biomarkers—measurable indicators of disease activit…

This study looks at how physical, psychological, and movement-related factors work together in adults with chronic knee pain. By tracking these factors over time, researchers hope to understand why pain experiences differ between people. The goal is to develop practical tools tha…

This study looks at records from over 500,000 Medicare beneficiaries with rheumatoid arthritis or ankylosing spondylitis who had major orthopedic procedures like joint replacements or spine surgery between 1999 and 2015. Researchers want to understand how often complications happ…

This study asks over 1,600 African American women aged 23-35 about their experiences during the COVID-19 pandemic. Participants fill out a short online or paper survey covering infection, vaccination, childcare, job loss, and emotional stress. The goal is to understand how the pa…

This study follows people who previously received NTLA-2001, an experimental gene-editing therapy, for a type of amyloidosis that can affect nerves or the heart. The goal is to monitor long-term safety and see if the therapy's effects on disease markers persist over time. Partici…

This study tests whether everyday rehabilitation therapy sessions can be recorded and measured more objectively using wrist-worn sensors, a video camera, and an audio recorder. Adults with neurological conditions like stroke, Parkinson's disease, or spinal cord injury will wear t…

This registry follows patients who receive donor cartilage or meniscus transplants for joint defects in the knee, hip, ankle, or shoulder. Researchers are collecting long-term data on pain, function, and whether the grafts need revision or fail over time. The goal is to understan…

This study tests whether a virtual reality brain-machine interface can help people with spinal cord injury regain function. Participants imagine moving their legs while wearing an EEG cap and VR headset, receiving sensory feedback. The goal is to understand how the brain's commun…

This study investigates whether chronic gum disease (periodontitis) is linked to changes in the autonomic nervous system — the body's automatic 'wiring' that controls heart rate, digestion, and stress responses. Researchers will measure heart rate variability, a marker of nervous…

This early-stage study in 16 healthy adults checks if taking a common stomach acid drug (rabeprazole) changes how the body absorbs a new experimental drug (TQ05105) being developed for myelofibrosis. Participants take TQ05105 alone and later with rabeprazole to compare drug level…

This study evaluates a blood test that uses genetic and epigenetic information to help doctors predict which rheumatoid arthritis medication will work best for each patient. Researchers will collect blood samples from 1,410 adults with rheumatoid arthritis who have not responded …

This study examines genetic test results from over 600 people who had acute myocarditis (heart muscle inflammation) confirmed by MRI. Researchers want to find out how common certain gene variants are in this group and whether they are linked to worse outcomes like heart failure o…

This study follows 100 people who already have short, 3D-printed dental implants in the back of the upper or lower jaw. Researchers measure bone loss and other dental health markers over three years to see how well these implants hold up. The goal is to learn whether these specia…

This study investigates how people physically interact with each other during tasks like collaboration, competition, and cooperation. The goal is to design robot controllers that mimic these human behaviors, which could then be used in devices like exoskeletons to improve motor l…

This study follows children and young adults (up to age 35) with brain or skull base tumors who are scheduled to receive radiation therapy to the brain. Researchers use brain scans to track changes in brain structure and volume over time. They also measure thinking skills, hormon…

This study looks at whether a rare tooth condition called taurodontism, where teeth have enlarged pulp chambers, is linked to gum disease. Researchers will review dental records and X-rays from healthy adults to compare gum health between those with and without taurodontism. The …

This study looks at how a stroke affects the jaw joint and chewing muscles. Researchers will use ultrasound to measure jaw structures in 70 stroke survivors and see if these measurements relate to their recovery. The goal is to better understand jaw problems after a stroke, which…

This study looks at whether detailed analysis of heart MRI images (called radiomics) can better predict life-threatening heart rhythms in people with hypertrophic cardiomyopathy (HCM), a condition where the heart muscle thickens. Researchers will also see if the drug mavacamten, …

This study looks at adults with temporomandibular disorders (TMD) — problems with the jaw joint and muscles — to measure how chronic pain, anxiety, depression, and perceived stress relate to each other. Researchers will use standard questionnaires to assess pain severity, depress…

This study investigates whether severe gum disease (periodontitis) changes the quality and quantity of a blood-derived material called leukocyte- and platelet-rich fibrin (L-PRF), which is used to help heal gums and bone after dental procedures. Researchers will compare L-PRF sam…

This study investigates how people with axial spondyloarthritis (axSpA) experience sudden worsening of symptoms, known as flares. Over 12 months, 40 participants use a digital diary to track symptoms, diet, lifestyle, and self-management strategies, and provide blood samples duri…

This study looks at how the position and angle of surgical anchors used in rotator cuff repair affect cyst formation and tendon healing. Researchers will use MRI scans to measure cyst volume and assess tendon recovery in 70 adults aged 18–70 undergoing primary arthroscopic repair…

This study looks for biological markers in the blood and tissue of adults with Marfan syndrome that could signal when an aortic aneurysm is dangerous enough to require surgery. Researchers will compare three groups of Marfan patients: those without aortic aneurysms, those with st…

This study explores whether a new type of resistance exercise is practical and safe for people with low bone mass, including those with osteopenia, osteoporosis, or sarcopenia. Over two months, one group performs progressive muscle-strengthening exercises while a control group co…

This study tests whether a simple isometric (static) hand exercise can change how people with rheumatoid arthritis feel pain. Researchers will measure pain tolerance, pressure thresholds, and muscle oxygen levels in 66 adults. The goal is to see if this type of exercise can help …

This study tests whether a simple mathematical formula, applied to routine CT scans, can accurately predict the size of a bone defect that will be created during surgery to remove a bone tumor. Accurate prediction could help surgeons select the right-sized donor bone graft before…

This study looks at whether people with flat feet (pes planus) are more likely to have piriformis syndrome, a condition that causes pain in the hip and lower back. Researchers will compare foot posture and pain in adults aged 18-65 who have piriformis syndrome with those who do n…

This study examines health data from about 800,000 Korean adults to see how often conditions like obesity, type 2 diabetes, heart disease, chronic kidney disease, and fatty liver occur together. Researchers will analyze national survey and insurance records from 2013 to 2023. No …

This study tests whether wearable sensors worn on the wrist and as a pendant can accurately track changes in arm and leg function in people with inclusion body myositis (IBM), a rare muscle disease that causes progressive weakness. Researchers aim to see if these sensors can prov…

This study was designed to look back at the health of people with Cushing's disease in Western France between 1990 and 2015. The goal was to find out how many patients went into remission and how many had their disease come back after their first surgery. However, the study was w…

This study follows 30 adults aged 45-80 who are having spinal fusion surgery for spondylolisthesis. Researchers will use CT scans to measure changes in the bone graft placed between vertebrae over time. The goal is to develop an objective way to assess whether the bones have fuse…

This study looks at how patients with advanced blood cancers (like acute myeloid leukemia) who are not eligible for a cure, along with their nurses and doctors, feel about the benefits of blood transfusions. Researchers will give questionnaires before each transfusion to compare …

This study follows 50 adults who had surgery for a broken shinbone to see if changes in the kneecap tendon's stiffness relate to knee pain. Researchers use a special ultrasound before and up to 6 months after surgery. The goal is to better understand why some people develop front…

This study was designed to see how accurately patients report their own medication and healthcare use in diaries compared to official health insurance records. It planned to include people with diabetes, arthritis, kidney disease, or prostate cancer. However, the study was withdr…

This study examines how often healthcare workers in a hospital's intensive care unit (ICU) experience physical, verbal, or sexual assaults from patients or their relatives. Researchers will review medical records of 865 adults who were in the ICU and had a reported incident of vi…

This study uses MRI scans to track changes in the jaw joint over 18 months in people with degenerative joint disease. Researchers will compare these scans to those from healthy volunteers to learn more about how the disease progresses. No drugs or contrast agents are used. The go…

This was a planned French study to collect information on chronic myeloid leukemia (CML) in young adults aged 18 to 30 who were treated with tyrosine kinase inhibitors. The goal was to describe their diagnosis, treatment choices, side effects, and quality of life. However, the st…

This study looks at people with ALS and similar diseases like frontotemporal dementia and hereditary spastic paraplegia. Researchers want to understand how genes affect the disease and find biological markers (biomarkers) to help develop future treatments. About 708 participants,…

This large observational study aims to collect medical data and biological samples from up to 5,000 people with chronic spinal cord injury or traumatic brain injury, as well as their family members and healthy volunteers. Researchers hope this information will help them better un…

This study looks at whether a 3-month non-surgical program—including patient education, supervised exercise, and diet counseling—can help people with knee osteoarthritis avoid knee replacement surgery while maintaining their quality of life. Researchers will follow 2,500 patients…

This study was designed to see if X-rays taken before knee replacement surgery could reliably show ligament damage in people with knee arthritis. It was an observational study, meaning no treatment was given. However, the study was withdrawn before enrolling any participants, so …

This 24-month observational study follows 100 people aged 12–50 with Limb Girdle Muscular Dystrophy type R1 (LGMD R1). Researchers will test whether a motor function scale called NSAD and muscle fat measurements from MRI can reliably track disease progression. The goal is to vali…

This 24-month observational study will follow 80 people with Becker muscular dystrophy (BMD) to better understand how the disease progresses. Researchers will measure muscle strength, walking speed, breathing, and heart function using standard tests. The goal is to identify which…

This study tests new radio frequency coils for MRI scanners to see if they can produce better images in children, including those with Duchenne muscular dystrophy. Researchers will check for side effects like heating and discomfort, and measure image quality. The goal is to impro…

This study compares three types of dental onlays (a type of filling that covers part of a tooth) for treating cavities. It involves 36 adults who each need at least three onlays. The onlays are made using 3D printing, milling, or indirect resin composite. Researchers will check h…

This study aims to create a tool that predicts which patients with inflammatory rheumatic diseases (like rheumatoid arthritis, vasculitis, or polymyalgia rheumatica) will develop serious side effects from long-term steroid use. Researchers will collect routine medical data—such a…

This study looked at how well 3D-printed custom insoles work for healthy adults and those with flat feet. About 100 people wore the insoles for 3 weeks, at least 3 hours each day. Researchers measured foot pressure, walking patterns, and how satisfied people were with the insoles…

This study aimed to compare how well people could walk after two different hip replacement surgeries: one through the front (direct anterior) and one through the back (posterior). It planned to include adults over 50 with hip arthritis. However, the study was withdrawn before enr…

This study looked at whether having more frequent contact with a clinician (at least once a week) improves satisfaction for people with long-lasting musculoskeletal conditions. Participants were split into two groups: one with standard contact and one with extra check-ins via tex…

This study looks at how well different types of dentures and implant-supported dental devices help people chew and how they affect quality of life. Researchers will compare conventional dentures, mini-implant overdentures, and implant-assisted partial dentures in 240 adults. The …

This study looks at how rotator cuff injuries—common causes of shoulder pain—might affect posture, trunk rotation, and balance. Researchers will compare 40 people with rotator cuff problems to 40 healthy volunteers, measuring things like spine curvature and balance using smartpho…

This study aimed to test different regional anesthesia techniques to help people recover faster and go home sooner after total knee replacement. It planned to compare a standard pain injection with an added nerve block or continuous nerve block infusion. However, the study was wi…

This study is for heart failure patients who do not have a specific heart rhythm pattern called left bundle branch block (non-LBBB). These patients often get a device called CRT-D, which combines a pacemaker and a defibrillator, but not everyone responds well. Researchers will fo…

This study uses an iPhone app to track symptoms of psoriasis and psoriatic arthritis in 1,000 adults. Participants complete surveys, take photos of their skin, and use phone sensors to measure joint function. The goal is to see if smartphones can reliably monitor these conditions…

This study follows 600 people with Albright hereditary osteodystrophy, a rare genetic condition affecting bones and hormones. Researchers are looking at how growth hormone treatment affects height and weight in those with a related hormone problem, and also studying thinking and …

This study looks at patients in intensive care who have an infection in a joint replacement (like a hip or knee). Researchers want to understand their care path, recovery, and survival over two years. The study will collect data from medical records and phone calls with patients …

This observational study looks at 103 adults with knee osteoarthritis to see if repetitive negative thinking (rumination and worry) is linked to worse pain and disability, even when X-ray damage is similar. Participants fill out questionnaires about their thoughts, pain, and dail…

This study tests a web-based tool called gp-multitool.de that helps general practitioners follow guidelines for older patients with multiple chronic conditions. About 659 patients from GP practices in Germany are taking part. The tool lets patients fill out questionnaires online …

This study will collect and analyze genetic data from 1000 people with suspected inherited metabolic diseases, including conditions like epilepsy and mitochondrial disorders. Researchers at Karolinska University Hospital aim to improve diagnosis by using advanced genetic testing …

This study looks at why some people with early rheumatoid arthritis develop long-lasting chronic pain while others do not. Researchers will use pain sensitivity tests and brain scans to find clues. The goal is to better understand the transition from acute to chronic pain, which …

This study follows about 700 women for up to 12 years after they had a uterine-sparing fibroid treatment, such as myomectomy or uterine artery embolization. Researchers want to see how long these treatments last before another procedure is needed, and how women's symptoms and qua…

This study looks at whether a tool called the Chelsea Critical Care Physical Assessment tool (CPAx) can accurately track recovery in 120 adults who developed muscle weakness after being on a breathing machine in the ICU. The goal is to find the smallest meaningful improvement tha…

This study aimed to find out how often chronic sinusitis occurs in children treated for head and neck cancer, and how it affects their quality of life. Researchers planned to compare these children to those treated for cancer elsewhere in the body using a questionnaire called SNO…

This study looks at whether diabetes or blood sugar problems can worsen thinking and memory issues in people with myotonic dystrophy type 1. Researchers will use MRI brain scans and thinking tests over 4 years to track changes. The goal is to understand why some patients have mor…

This study looks at whether artificial intelligence can help dentists plan where to place dental implants in people who have lost all their lower teeth. Researchers will use old CT scans to compare AI-generated implant plans with plans made by expert dentists. The goal is to see …

This study follows 75 adults with benign or slow-growing brain tumors who are receiving partial brain radiation. Researchers will use memory tests and MRI scans before treatment and at 6 and 12 months after to see how radiation affects thinking and memory. The goal is to identify…

This study follows 26 people who had hip surgery (periacetabular osteotomy) for hip dysplasia. Researchers want to see how many return to their favorite sports and how well they recover. The study collects data from medical records and patient reports, focusing on pain levels and…