Could a smart dental filler stop white spots before they start?
NCT ID NCT07715942
First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time
Summary
This trial tests whether a bioactive resin containing S-PRG filler, used as attachment material for clear orthodontic aligners, can prevent white spot lesions (early decay) on tooth enamel. Fifty healthy young adults with mild to moderate crowding will be randomly assigned to receive either the bioactive resin or a standard flowable composite for their aligner attachments. The study measures changes in lesion area and mineral loss using a quantitative light-induced fluorescence system.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- bioactive resin composite containing S-PRG filler
- What this could lead to
- If it works, this could offer a way to prevent white spot lesions (early tooth decay) during orthodontic treatment with clear aligners.
- What could go wrong
- This is a small early-stage trial with 50 participants, so results may not apply broadly. The material may not significantly reduce lesions compared to standard composites.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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50 people
The number who actually took part.
- Started
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Jul 2025
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 30 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Healthy young adult orthodontic patients * Class 1 malocclusion with mild to moderate crowding (\<6 mm). * Non extraction treatment plan. * Optimum oral Hygiene before treatment. * A maximum of three restored teeth with either fillings or prosthesis. Exclusion Criteria: * Patients with defective enamel, fluorosis, hypocalcification or enamel hypoplasia. * Extensive restorations. * Syndromes and Oro-facial anomalies. * Salivary gland diseases. * Patients who are pregnant, diabetic, or using mouth rinses or interacting medications, including antibiotic therapy.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Postgraduate Orthodontic Clinics
Irbid, 22110, Jordan
More trials for these conditions
Other studies related to the condition(s) this trial covers.