Gum disease may throw off the body's internal wiring — a heart-rhythm test puts the idea to the test

NCT ID NCT07735312

Ongoing Knowledge-focused Sponsor: University of Sao Paulo Source: ClinicalTrials.gov ↗

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This study investigates whether chronic gum disease (periodontitis) is linked to changes in the autonomic nervous system — the body's automatic 'wiring' that controls heart rate, digestion, and stress responses. Researchers will measure heart rate variability, a marker of nervous system balance, in 50 adults with and without periodontitis. They will also check blood levels of inflammatory markers to see if any connection involves inflammation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: non-surgical periodontal therapy (scaling and root planing)
What this could lead to: If a link is found, it could point toward better ways to monitor or manage the body-wide effects of gum disease.
What could go wrong: This is a small observational study, so it cannot prove cause and effect. Results may not apply to everyone with periodontitis.

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Conditions

The condition(s) this trial relates to.

periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC ELECTROPHYSIOLOGY PERIODONTITIS

Contacts and locations

Locations

FORP-USP

Ribeirão Preto, São Paulo, 14.040-904, Brazil

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