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Which cavity-stopping silver treatment works best for kids? a head-to-head trial

NCT ID NCT07708883

Disease control Sponsor: National Research Centre, Egypt Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 16, 2026 · Last updated Jul 29, 2026 · Updated 3 times

Summary

This trial compares two marketed brands of silver diamine fluoride (SDF) to see which is more effective at stopping tooth decay in children aged 4 to 7. Both treatments are applied to cavities and leave a black stain. Researchers will follow the children for one year, checking whether the decay has stopped by feeling the hardness of the tooth and noting its color.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
silver diamine fluoride (SDF) in two marketed brands: ToothMate® (Egypt) and Advantage Arrest (USA)
What this could lead to
If one brand proves more effective, it could offer a simpler, cheaper way to stop cavities in young children without drilling.
What could go wrong
This is a small, early-stage comparison with only 134 children, and both treatments leave black stains on teeth. Results may not apply to all children or settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

134 people

The number who actually took part.

Started

Oct 2025

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

4 to 8 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Children who are apparently healthy with primary carious teeth aged from 4-7 years. * Uncooperative children. * Children with financial barrier in accessing dental care * Clinically: absence of any pathology or pain except of sensitivity with eating. * Parents and patients accepting the new treatment modality and parents assigned the informed consent. Exclusion Criteria: * Known sensitivity to silver or other heavy-metal ions. * Children who will not comply to recall program. * Teeth with pulp involvement. * Tooth mobility (more than grade 1 (grade 1:1-2 mm tooth mobility). * History of pain for a long period of time that may indicate chronic pulp inflammation.

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Conditions

The condition(s) this trial relates to.

dental caries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dental caries

Contacts and locations

Locations

  • National Research Centre

    Cairo, Cairo Governorate, 12572, Egypt

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