Which cavity-stopping silver treatment works best for kids? a head-to-head trial

NCT ID NCT07708883

Ongoing Disease control Sponsor: National Research Centre, Egypt Source: ClinicalTrials.gov ↗

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This trial compares two marketed brands of silver diamine fluoride (SDF) to see which is more effective at stopping tooth decay in children aged 4 to 7. Both treatments are applied to cavities and leave a black stain. Researchers will follow the children for one year, checking whether the decay has stopped by feeling the hardness of the tooth and noting its color.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: silver diamine fluoride (SDF) in two marketed brands: ToothMate® (Egypt) and Advantage Arrest (USA)
What this could lead to: If one brand proves more effective, it could offer a simpler, cheaper way to stop cavities in young children without drilling.
What could go wrong: This is a small, early-stage comparison with only 134 children, and both treatments leave black stains on teeth. Results may not apply to all children or settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

dental caries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DENTAL CARIES

Contacts and locations

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Locations

National Research Centre

Cairo, Cairo Governorate, 12572, Egypt

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