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Could a common cholesterol drug shrink uterine fibroids?

NCT ID NCT03400826

Ongoing Disease control Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time

Summary

This phase II trial tests whether simvastatin, a widely used cholesterol medication, can reduce the size of uterine fibroids and ease related symptoms. Researchers will give 60 women either simvastatin or a placebo daily for 12 weeks, measuring fibroid volume by ultrasound and tracking symptom changes with a validated questionnaire. The goal is to find a simple, drug-based alternative to surgery for fibroids.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
simvastatin 40 mg daily for 12 weeks
What this could lead to
If it works, this could point toward a non-surgical treatment for uterine fibroids using a common, low-cost drug.
What could go wrong
This is a small, early-phase trial with only 60 participants. The drug may not shrink fibroids or improve symptoms, and simvastatin has known side effects like muscle pain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

leiomyoma uterine corpus leiomyoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FIBROID TUMOR FIBROID UTERUS FIBROMYOMA LEIOMYOMA LEIOMYOMA, UTERINE

Contacts and locations

Locations

  • Johns Hopkins Hospital

    Baltimore, Maryland, 21218, United States

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