Could a short course of steroids calm a dangerous heart rhythm?

NCT ID NCT06635863

ENROLLING_BY_INVITATION Disease control Sponsor: Roderick Tung Source: ClinicalTrials.gov ↗

First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time

Summary

This trial tests whether an 8-week course of the immunosuppressive drug prednisone can reduce episodes of ventricular tachycardia (a potentially fatal fast heart rhythm) and improve heart function in people with non-ischemic cardiomyopathy and confirmed heart inflammation. Participants are randomly assigned to receive either prednisone plus standard heart-failure therapy or standard therapy alone. The study tracks heart rhythm, ejection fraction, and inflammation on PET scans to see if calming the immune system helps the heart.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: an 8-week course of prednisone (an immunosuppressive steroid)
What this could lead to: If it works, this could offer a non-invasive treatment option for people with ventricular tachycardia linked to heart inflammation, potentially reducing the need for procedures or hospital stays.
What could go wrong: This is a small, early-phase trial with only 40 participants. Prednisone has known side effects, and the benefit may not be confirmed in larger studies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

arrhythmogenic right ventricular cardiomyopathy cardiac rhythm disease intrinsic cardiomyopathy ventricular tachycardia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARRHYTHMOGENIC INFLAMMATORY CARDIOMYOPATHY NON-ISCHEMIC CARDIOMYOPATHY VENTRICULAR ARRYTHMIA

Contacts and locations

Locations

Banner - University Medical Center, Phoenix campus

Phoenix, Arizona, 85006, United States

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