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MRI scans could help decide who needs a heart defibrillator

NCT ID NCT01918215

Completed Disease control Sponsor: Flinders University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 09, 2026 · Updated 2 times

Summary

This study tested whether using a heart MRI to find scar tissue can help decide which people with mild-to-moderate heart failure should get a defibrillator (ICD) to prevent sudden cardiac death. About 449 adults with a weakened heart pump (ejection fraction 36-50%) and scar tissue on MRI were randomly assigned to receive an ICD or a small heart monitor. The goal was to see if the ICD group had fewer dangerous heart rhythms or sudden death over three years.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder dilated cardiomyopathy heart failure intrinsic cardiomyopathy left ventricular failure myocardial ischemia systolic heart failure Ventricular Dysfunction, Left

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE LEFT VENTRICULAR SYSTOLIC DYSFUNCTION

Contacts and locations

Locations

  • Belfast Health and Social Care Trust

    Belfast, BT12 6NT, United Kingdom

  • Coburg Hospital

    Coburg, 96450, Germany

  • Flinders Medical Centre

    Bedford Park, South Australia, 5042, Australia

  • Glenfield General Hospital

    Leicester, LE39QP, United Kingdom

  • Golden Jubilee National Hospital

    Clydebank, G814DY, United Kingdom

  • John Hunter Hospital

    New Lambton, New South Wales, 2305, Australia

  • Lyell McEwin Hospital

    Elizabeth Vale, South Australia, 5112, Australia

  • Princess Alexandra Hospital

    Brisbane, Queensland, 4102, Australia

  • Royal Brisbane & Women's Hospital

    Herston, Queensland, 4029, Australia

  • Royal Hobart Hospital

    Hobart, Tasmania, 7000, Australia

  • Royal Perth Hospital

    Perth, Western Australia, 6000, Australia

  • Schwarzwald-Baar Klinikum

    Villingen-Schwenningen, 78052, Germany

  • Sir Charles Gairdner Hospital

    Nedlands, Western Australia, 6009, Australia

  • St Vincent's Hospital

    Fitzroy, Victoria, 3065, Australia

  • The Alfred

    Melbourne, Victoria, 3004, Australia

  • The Bristol Heart Institute

    Bristol, BS2 8HW, United Kingdom

  • University Hospital Wurzburg

    Würzburg, 97080, Germany

  • University Hospital of South Manchester NHS Foundation Trust

    Manchester, M23 9LT, United Kingdom

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