Gum disease may weaken the Body's own dental healing clot
NCT ID NCT07693725
First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time
Summary
This study investigates whether severe gum disease (periodontitis) changes the quality and quantity of a blood-derived material called leukocyte- and platelet-rich fibrin (L-PRF), which is used to help heal gums and bone after dental procedures. Researchers will compare L-PRF samples from 32 adults—half with healthy gums and half with advanced gum disease—looking at the structure, cell content, and growth factor release. The goal is to understand if the body's systemic inflammation from gum disease affects the healing power of this natural biomaterial.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Leukocyte- and platelet-rich fibrin (L-PRF)
- What this could lead to
- If gum disease alters L-PRF properties, dentists may need to adjust regenerative treatments for patients with periodontitis.
- What could go wrong
- This is a small observational study (32 people) that only measures lab differences, not treatment outcomes. Results may not change clinical practice.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Suleyman Demirel University, Faculty of Dentistry, Department of Periodontology
Isparta, Isparta, 32000, Turkey (Türkiye)
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