One-Shot gene therapy could end frequent eye injections for wet AMD

NCT ID NCT05407636

Recruiting now Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 29 times

Summary

This study tests a one-time gene therapy called RGX-314 for wet age-related macular degeneration (AMD), a leading cause of vision loss. The goal is to see if it can control the disease as well as standard treatments that require eye injections every few months. About 714 adults aged 50-89 who have already responded to anti-VEGF therapy will receive either the gene therapy or standard injections. If successful, this could greatly reduce the burden of lifelong treatment.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

A.O.U. Consorziale Policlinico di Bari /ID# 262500
ACTIVE_NOT_RECRUITING

Bari, 70124, Italy
AP-HP - Groupe Hospitalier 10e - Hopital Lariboisiere /ID# 262406
ACTIVE_NOT_RECRUITING

Paris, 75010, France
ASL 2 Abruzzo Lanciano-Vasto-Chieti /ID# 263923
ACTIVE_NOT_RECRUITING

Chieti, 67100, Italy
ASST Fatebenefratelli Sacco /ID# 263273
ACTIVE_NOT_RECRUITING

Milan, Milano, 20157, Italy
ASU FC - P.O. Universitario Santa Maria della Misericordia /ID# 263036
ACTIVE_NOT_RECRUITING

Udine, 33100, Italy
Advanced Vision Research Institute /ID# 256380
RECRUITING

Longmont, Colorado, 80503, United States
Alberta Retina Consultants /ID# 265599
ACTIVE_NOT_RECRUITING

Edmonton, Alberta, T5H 0X5, Canada
Asheville Eye Associates- Retina Division /ID# 256355
RECRUITING

Asheville, North Carolina, 28803, United States
Associated Retinal Consultants /ID# 256269
RECRUITING

Royal Oak, Michigan, 48073, United States
Austin Clinical Research, LLC /ID# 256274
COMPLETED

Austin, Texas, 78750-2298, United States
Austin Research Center for Retina /ID# 256265
RECRUITING

Austin, Texas, 78705, United States
Austin Retina Associates - Round Rock /ID# 256387
RECRUITING

Round Rock, Texas, 78681, United States
Azienda Ospedaliera Universitaria Luigi Vanvitelli /ID# 264074
ACTIVE_NOT_RECRUITING

Naples, Napoli, 80138, Italy
Azienda Ospedaliero-Universitaria di Ferrara - Arcispedale S.Anna /ID# 262896
ACTIVE_NOT_RECRUITING

Cona, Ferrara, 44124, Italy
Barnet Dulaney Eye Center-Phoenix /ID# 256340
RECRUITING

Phoenix, Arizona, 85016, United States
Bay Area Retina Associates - Walnut Creek - Lennon Lane /ID# 268513
RECRUITING

Walnut Creek, California, 94598, United States
Black Hills Regional Eye Institute /ID# 262872
RECRUITING

Rapid City, South Dakota, 57701, United States
Bradford Royal Infirmary /ID# 273164
ACTIVE_NOT_RECRUITING

Bradford, BD9 6RJ, United Kingdom
Bristol Eye Hospital /ID# 271619
COMPLETED

Bristol, BS1 2LX, United Kingdom
Budapest Retina Intezet /ID# 262647
ACTIVE_NOT_RECRUITING

Budapest, 1133, Hungary
Byers Eye Institute Stanford /ID# 262853
RECRUITING

Palo Alto, California, 94303, United States
CHU Dijon /ID# 262410
ACTIVE_NOT_RECRUITING

Dijon, Cote-d Or, 21000, France
CHU de Quebec-Universite Laval /ID# 258996
COMPLETED

Québec, Quebec, G1R 2J6, Canada
Calgary Retina Consultants /ID# 258997
ACTIVE_NOT_RECRUITING

Calgary, Alberta, T2H 0C8, Canada
California Retina Consultants - Bakersfield /ID# 256240
RECRUITING

Bakersfield, California, 93309-1677, United States
California Retina Consultants - Oxnard - North Ventura Road /ID# 262883
RECRUITING

Oxnard, California, 93036, United States
Center for Retina and Macular Disease /ID# 256335
RECRUITING

Winter Haven, Florida, 33880, United States
Centre Hosp Intercommunal de Creteil /ID# 262407
ACTIVE_NOT_RECRUITING

Créteil, Val-de-Marne, 94000, France
Centre Hospitalier Universitaire de Nantes, Hotel Dieu -HME /ID# 262408
ACTIVE_NOT_RECRUITING

Nantes, Pays de la Loire Region, 44000, France
Centre Hospitalier Universitaire de Nice - Hopital Pasteur /ID# 262418
ACTIVE_NOT_RECRUITING

Nice, Alpes-Maritimes, 06001, France
Charles Retina Institute /ID# 256237
COMPLETED

Germantown, Tennessee, 38138, United States
Charleston Neuroscience Institute - Beaufort /ID# 256385
RECRUITING

Beaufort, South Carolina, 29902-6216, United States
Charleston Neurosciences Institute /ID# 256336
RECRUITING

Ladson, South Carolina, 29414-5896, United States
Charleston Neurosciences Institute /ID# 256351
RECRUITING

Charleston, South Carolina, 29414-5896, United States
Chu De Toulouse - Hopital Pierre Paul Ricquet /ID# 262411
ACTIVE_NOT_RECRUITING

Toulouse, Occitanie, 31059, France
Cincinnati Eye Institute /ID# 256247
RECRUITING

Cincinnati, Ohio, 45242-5664, United States
Cleveland Clinic - Cleveland /ID# 256282
ACTIVE_NOT_RECRUITING

Cleveland, Ohio, 44195, United States
Clinica Baviera /ID# 270146
COMPLETED

Madrid, 28046, Spain
Clinique Honoré Cave /ID# 262225
ACTIVE_NOT_RECRUITING

Montauban, 82017, France
Clinique Juge /ID# 262417
ACTIVE_NOT_RECRUITING

Marseille, Provence-Alpes-Côte d'Azur Region, 13008, France
Colorado Retina Associates /ID# 256378
COMPLETED

Lakewood, Colorado, 80228, United States
Columbia University of New York - Edward S. Harkness Eye Institute /ID# 256342
ACTIVE_NOT_RECRUITING

New York, New York, 10032, United States
Complejo Hospitalario Universitario Insular-Materno Infantil de Gran Canaria /ID# 262633
ACTIVE_NOT_RECRUITING

Las Palmas de Gran Canaria, Las Palmas, 35016, Spain
Complejo Hospitalario Universitario de Santiago (CHUS) /ID# 262632
ACTIVE_NOT_RECRUITING

Santiago de Compostela, A Coruna, 15706, Spain
Debreceni Egyetem-Klinikai Kozpont /ID# 262646
ACTIVE_NOT_RECRUITING

Debrecen, Hajdú-Bihar, 4032, Hungary
Duke University Medical Center /ID# 256245
RECRUITING

Durham, North Carolina, 27710, United States
Emanuelli Research & Development Center LLC /ID# 256231
ACTIVE_NOT_RECRUITING

Arecibo, 00612, Puerto Rico
Envision Ocular, LLC /ID# 256367
RECRUITING

Bloomfield, New Jersey, 07003, United States
Florida Retina Consultants /ID# 256321
RECRUITING

Lakeland, Florida, 33805, United States
Florida Retina Institute - Orlando /ID# 256373
RECRUITING

Orlando, Florida, 32806-1101, United States
Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Università Cattolica /ID# 263037
ACTIVE_NOT_RECRUITING

Rome, Roma, 00168, Italy
Fort Lauderdale Eye Institute /ID# 266011
COMPLETED

Plantation, Florida, 33324, United States
Fukushima Medical University Hospital /ID# 258411
RECRUITING

Fukushima, Fukushima, 960-1295, Japan
Ganglion Orvosi Központ /ID# 264550
ACTIVE_NOT_RECRUITING

Pécs, 7621, Hungary
Georgia Retina - Marietta /ID# 256264
RECRUITING

Marietta, Georgia, 30060, United States
Gloucestershire Royal Hospital /ID# 277362
COMPLETED

Gloucester, Gloucestershire, GL1 3NN, United Kingdom
Graystone Eye /ID# 256424
RECRUITING

Hickory, North Carolina, 28602, United States
Gundersen Health System - La Crosse Medical Center /ID# 276012
RECRUITING

La Crosse, Wisconsin, 54601, United States
Hopitaux Universitaires Paris Centre-Hopital Cochin /ID# 262415
ACTIVE_NOT_RECRUITING

Paris, Paris, 75679, France
Hospital Arruzafa /ID# 262634
ACTIVE_NOT_RECRUITING

Córdoba, Cordoba, 14012, Spain
Hospital Santa Creu i Sant Pau /ID# 262637
ACTIVE_NOT_RECRUITING

Barcelona, 08041, Spain
Hospital Universitari de Bellvitge /ID# 262641
ACTIVE_NOT_RECRUITING

L'Hospitalet de Llobregat, Barcelona, 08907, Spain
Hospital Universitario 12 de Octubre /ID# 262636
ACTIVE_NOT_RECRUITING

Madrid, 28041, Spain
Hospital Universitario Puerta de Hierro - Majadahonda /ID# 262635
ACTIVE_NOT_RECRUITING

Majadahonda, Madrid, 28222, Spain
Hyogo Medical University Hospital /ID# 257893
RECRUITING

Nishinomiya-shi, Hyōgo, 663-8501, Japan
Hôpital de la Croix Rousse - Groupement Hospitalier Nord /ID# 262409
ACTIVE_NOT_RECRUITING

Lyon, Auvergne-Rhône-Alpes, 69004, France
IRCCS Fondazione G.B. Bietti per lo studio e la ricerca in Oftalmologia- ONLUS /ID# 262897
COMPLETED

Rome, Roma, 00184, Italy
IRCCS Ospedale Sacro Cuore Don Calabria /ID# 263536
COMPLETED

Negrar, Verona, 37024, Italy
IRCCS Ospedale San Raffaele /ID# 263035
ACTIVE_NOT_RECRUITING

Milan, Milano, 20132, Italy
Illinois Retina Associates - Oak Park /ID# 256375
ACTIVE_NOT_RECRUITING

Oak Park, Illinois, 60304, United States
Institut Clínic d'Oftalmologia (ICOF). Hospital Clínic d'Oftalmologia. /ID# 262644
COMPLETED

Barcelona, 08028, Spain
Instituto de Microcirugía Ocular /ID# 262642
COMPLETED

Barcelona, 08035, Spain
Jacobs Retina Center at UCSD/ID# 256320
ACTIVE_NOT_RECRUITING

La Jolla, California, 92093, United States
John-Kenyon American Eye Institute -New Albany /ID# 256283
ACTIVE_NOT_RECRUITING

New Albany, Indiana, 47150, United States
Johns Hopkins Hospital /ID# 256236
COMPLETED

Baltimore, Maryland, 21287, United States
Juntendo University Hospital /ID# 258715
RECRUITING

Bunkyo-ku, Tokyo, 113-8431, Japan
Kagoshima University Hospital /ID# 257053
RECRUITING

Kagoshima, Kagoshima-ken, 890-8520, Japan
Kaiser Permanente - Riverside Medical Center /ID# 262413
RECRUITING

Riverside, California, 92505, United States
Klinikum Ludwigshafen /ID# 262497
ACTIVE_NOT_RECRUITING

Ludwigshafen am Rhein, Rhineland-Palatinate, 67063, Germany
Knappschaftsklinikum Saar /ID# 262496
COMPLETED

Püttlingen, 66346, Germany
Kobe City Eye Hospital /ID# 256948
RECRUITING

Kobe, Hyōgo, 650-0047, Japan
Kyoto University Hospital /ID# 267351
RECRUITING

Kyoto, Kyoto, 606-8507, Japan
Leeds Teaching Hospital /ID# 277366
COMPLETED

Leeds, West Yorkshire, LS9 7TF, United Kingdom
Liverpool University Hospitals NHS Foundation Trust /ID# 262305
ACTIVE_NOT_RECRUITING

Liverpool, L7 8XP, United Kingdom
MA Eye & Ear Infirmary /ID# 262430
ACTIVE_NOT_RECRUITING

Boston, Massachusetts, 02114, United States
Macula Retina Vitreous Center - Torrance /ID# 270247
RECRUITING

Torrance, California, 90503, United States
Maine Eye Center - Marginal Way Campus /ID# 256391
RECRUITING

Portland, Maine, 04101, United States
Manchester University NHS Foundation Trust /ID# 262404
COMPLETED

Manchester, M9 2AA, United Kingdom
Mayo Clinic - Rochester /ID# 258295
RECRUITING

Rochester, Minnesota, 55905-0001, United States
Mid America Surgery Center /ID# 258993
COMPLETED

Chesterfield, Missouri, 63017, United States
Mid Atlantic Retina /ID# 256232
ACTIVE_NOT_RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Mid Atlantic Retina Specialists - Hagerstown /ID# 256310
ACTIVE_NOT_RECRUITING

Hagerstown, Maryland, 21740-5965, United States
Midwest Retina /ID# 276644
COMPLETED

Dublin, Ohio, 43016, United States
Mississippi Retina Associates /ID# 270934
RECRUITING

Madison, Mississippi, 39110-2028, United States
Monmouth Retina Consultants /ID# 275895
RECRUITING

Little Silver, New Jersey, 07739, United States
Moorfields Eye Hospital /ID# 263038
COMPLETED

London, Greater London, EC1V 2PD, United Kingdom
Nagoya University Hospital /ID# 267350
RECRUITING

Nagoya, Aichi-ken, 466-8560, Japan
National Ophthalmic Research Institute /ID# 256344
ACTIVE_NOT_RECRUITING

Fort Myers, Florida, 33912-7125, United States
Northwestern Memorial Hospital - Department of Ophthalmology /ID# 256379
RECRUITING

Chicago, Illinois, 60611-2987, United States
Ohio State University /ID# 256275
RECRUITING

Columbus, Ohio, 43210, United States
Ophthalmic Consultants of Boston /ID# 256233
RECRUITING

Boston, Massachusetts, 02114, United States
Orange County Retina Medical Group /ID# 256286
RECRUITING

Santa Ana, California, 92705, United States
Ottawa Hospital Research Institute /ID# 258998
ACTIVE_NOT_RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
Oxford University Hospitals NHS Foundation Trust /ID# 262306
ACTIVE_NOT_RECRUITING

Oxford, Oxfordshire, OX3 9DU, United Kingdom
Pacific Northwest Retina /ID# 258999
COMPLETED

Bellevue, Washington, 98004, United States
Palmetto Retina Center-Florence /ID# 256244
COMPLETED

Florence, South Carolina, 29501, United States
Piedmont Eye Center /ID# 256386
COMPLETED

Lynchburg, Virginia, 24502, United States
Rand Eye Institute /ID# 256337
COMPLETED

Deerfield Beach, Florida, 33064, United States
Retina Associates - Lenexa /ID# 258296
RECRUITING

Lenexa, Kansas, 66215, United States
Retina Associates of Cleveland-Middleburg Heights /ID# 256280
ACTIVE_NOT_RECRUITING

Cleveland, Ohio, 44130, United States
Retina Associates of Michigan /ID# 256393
RECRUITING

Grand Blanc, Michigan, 48439, United States
Retina Associates of South Texas
RECRUITING

San Antonio, Texas, 78240, United States
Retina Associates of Utah /ID# 256276
RECRUITING

Salt Lake City, Utah, 84107, United States
Retina Associates of Western New York /ID# 256374
COMPLETED

Rochester, New York, 14620, United States
Retina Center NW, PLLC /ID# 256395
RECRUITING

Silverdale, Washington, 98383, United States
Retina Center Of Texas (Rct) - Southlake /ID# 256281
RECRUITING

Southlake, Texas, 76092, United States
Retina Centre of Ottawa /ID# 259659
ACTIVE_NOT_RECRUITING

Ottawa, Ontario, K2B 7E9, Canada
Retina Consultants of Hawaii /ID# 256278
RECRUITING

‘Aiea, Hawaii, 96701, United States
Retina Consultants of Orange County /ID# 256267
ACTIVE_NOT_RECRUITING

Fullerton, California, 92835, United States
Retina Consultants of San Diego /ID# 256258
ACTIVE_NOT_RECRUITING

Poway, California, 92064-2530, United States
Retina Consultants of Southern Colorado /ID# 256285
RECRUITING

Colorado Springs, Colorado, 80909, United States
Retina Consultants of Texas - Bellaire /ID# 256377
RECRUITING

Bellaire, Texas, 77401, United States
Retina Consultants of Texas /ID# 256382
RECRUITING

San Antonio, Texas, 78251, United States
Retina Consultants of Texas/ID# 259661
RECRUITING

San Antonio, Texas, 78240-1655, United States
Retina Consultants, P.C. /ID# 273610
RECRUITING

Manchester, Connecticut, 06042-3556, United States
Retina Institute of Virginia /ID# 256394
COMPLETED

Richmond, Virginia, 23235, United States
Retina Macula Institute of Arizona /ID# 271026
RECRUITING

Scottsdale, Arizona, 85255-4134, United States
Retina Partners Midwest, PC /ID# 256277
RECRUITING

Indianapolis, Indiana, 46290, United States
Retina Research Institute of Texas /ID# 256263
COMPLETED

Abilene, Texas, 79606-1224, United States
Retina Specialists /ID# 256392
ACTIVE_NOT_RECRUITING

Baltimore, Maryland, 21204, United States
Retina Specialty Institute /ID# 256268
RECRUITING

Pensacola, Florida, 32503, United States
Retina Surgical Associates /ID# 270958
ACTIVE_NOT_RECRUITING

New Westminster, British Columbia, V3L 5H1, Canada
Retina Vitreous Assoc Med Grp /ID# 256246
RECRUITING

Beverly Hills, California, 90211, United States
Retina Vitreous Associates of Florida - St. Petersburg /ID# 256279
RECRUITING

St. Petersburg, Florida, 33711-1141, United States
Retina Vitreous Center, Research /ID# 256284
RECRUITING

Edmond, Oklahoma, 73013, United States
Retinal Consultants Medical Group, Inc. - Greenback /ID# 256353
ACTIVE_NOT_RECRUITING

Sacramento, California, 95841, United States
Retinal Diagnostic Center /ID# 256262
RECRUITING

Campbell, California, 95008, United States
Retinal Research Institute /ID# 256238
RECRUITING

Phoenix, Arizona, 85053, United States
Rocky Mountain Retina Consultants /ID# 256369
ACTIVE_NOT_RECRUITING

Murray, Utah, 84107, United States
Royal Victoria Infirmary /ID# 277368
ACTIVE_NOT_RECRUITING

Newcastle upon Tyne, NE1 4LP, United Kingdom
Shiga University of Medical Science /ID# 266862
RECRUITING

Ōtsu, Shiga, 520-2192, Japan
Sierra Eye Associates /ID# 256239
COMPLETED

Reno, Nevada, 89502, United States
Southeastern Retina Associates - Chattanooga /ID# 258992
COMPLETED

Chattanooga, Tennessee, 37421, United States
Southeastern Retina Associates - Johnson City /ID# 256396
RECRUITING

Johnson City, Tennessee, 37604, United States
Southwest Retina Research Center /ID# 256261
ACTIVE_NOT_RECRUITING

Durango, Colorado, 81303, United States
Spokane Eye Clinic /ID# 256338
ACTIVE_NOT_RECRUITING

Spokane, Washington, 99204, United States
Springfield Clinic - First /ID# 256371
RECRUITING

Springfield, Illinois, 62702, United States
Star Retina - Burleson /ID# 256376
ACTIVE_NOT_RECRUITING

Burleson, Texas, 76028, United States
Stoke Mandeville Hospital /ID# 277343
ACTIVE_NOT_RECRUITING

Aylesbury, Buckinghamshire, HP21 8AL, United Kingdom
Sunderland Eye Infirmary /ID# 271620
COMPLETED

Sunderland, SR2 9HP, United Kingdom
Sunnybrook Research Institute /ID# 270690
ACTIVE_NOT_RECRUITING

Toronto, Ontario, M4N 3M5, Canada
Tennessee Retina - Nashville /ID# 256388
RECRUITING

Nashville, Tennessee, 37203-1513, United States
Texas Retina Associates - Fort Worth /ID# 256326
RECRUITING

Fort Worth, Texas, 76104, United States
Texas Retina Associates /ID# 256259
RECRUITING

Dallas, Texas, 75231, United States
The Retina Clinic London /ID# 262304
ACTIVE_NOT_RECRUITING

London, Greater London, W1G 7LB, United Kingdom
The Retina Partners - Encino /ID# 259660
RECRUITING

Encino, California, 91436, United States
Toronto Retina Institute /ID# 265602
ACTIVE_NOT_RECRUITING

Toronto, Ontario, M3C 0G9, Canada
UC Davis Health Eye Center
ACTIVE_NOT_RECRUITING

Sacramento, California, 95817, United States
Universitaetsklinikum Bonn /ID# 262498
ACTIVE_NOT_RECRUITING

Bonn, North Rhine-Westphalia, 53127, Germany
Universitaetsklinikum Freiburg /ID# 262495
ACTIVE_NOT_RECRUITING

Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
Universitaetsklinikum Hamburg-Eppendorf /ID# 262493
ACTIVE_NOT_RECRUITING

Hamburg, 20246, Germany
Universitaetsklinikum Muenster /ID# 262499
ACTIVE_NOT_RECRUITING

Münster, North Rhine-Westphalia, 48149, Germany
Universitaetsklinikum Ulm /ID# 262494
ACTIVE_NOT_RECRUITING

Ulm, Baden-Wurttemberg, 89081, Germany
University Hospital Southampton NHS Foundation Trust /ID# 262307
ACTIVE_NOT_RECRUITING

Southampton, Hampshire, SO16 6YD, United Kingdom
University Retina and Macula Associates /ID# 256287
COMPLETED

Oak Forest, Illinois, 60452, United States
University Retina and Macula Associates /ID# 256288
ACTIVE_NOT_RECRUITING

Lemont, Illinois, 60439, United States
University of British Columbia - Eye Care Centre, Vancouver General Hospital /ID# 266014
COMPLETED

Vancouver, British Columbia, V5Z 3N9, Canada
University of Missouri Hospital /ID# 262474
RECRUITING

Columbia, Missouri, 65212, United States
University of Miyazaki Hospital /ID# 262879
RECRUITING

Miyazaki, Miyazaki, 889-1692, Japan
University of Pennsylvania /ID# 258995
ACTIVE_NOT_RECRUITING

Philadelphia, Pennsylvania, 19104-5502, United States
University of Pittsburgh Medical Center /ID# 258994
ACTIVE_NOT_RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
Vanderbilt University Medical Center /ID# 256372
RECRUITING

Nashville, Tennessee, 37232-0011, United States
Vistar Eye Center /ID# 271024
RECRUITING

Roanoke, Virginia, 24019, United States
Vitreo Retinal Associates - Worcester /ID# 266008
RECRUITING

Worcester, Massachusetts, 01605, United States
VitreoRetinal Surgery PLLC DBA Retina Consultants of Minnesota /ID# 256272
RECRUITING

Edina, Minnesota, 55435, United States
Vitreoretinal Associates, P.A. /ID# 256266
ACTIVE_NOT_RECRUITING

Gainesville, Florida, 32607, United States
Vitreous Retina Macula Specialists of Toronto /ID# 258299
ACTIVE_NOT_RECRUITING

Etobicoke, Ontario, M8X 2X3, Canada
Wagner Kapoor Research Institute - Norfolk /ID# 256260
COMPLETED

Norfolk, Virginia, 23502, United States
Washington University School of Medicine - St. Louis /ID# 256383
RECRUITING

St Louis, Missouri, 63108, United States
Western Eye Hospital /ID# 271621
ACTIVE_NOT_RECRUITING

London, England, NW1 5QH, United Kingdom
Wolfe Eye Clinic - West Des Moines /ID# 256314
ACTIVE_NOT_RECRUITING

West Des Moines, Iowa, 50266, United States

Conditions

Explore the condition pages connected to this study.

AMD CNV NAMD WAMD WET AGE RELATED MACULAR DEGENERATION WETAMD WETAMD