One-Shot gene therapy could end monthly eye injections for wet AMD

NCT ID NCT05407636

Ongoing Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 04, 2026 · Updated 2 times

Summary

This study tests a one-time gene therapy called RGX-314 for wet age-related macular degeneration (AMD), a leading cause of vision loss. About 714 adults aged 50-89 who currently need regular eye injections will receive either the gene therapy or standard treatment. The goal is to see if a single dose can control the disease as well as repeated injections, reducing the treatment burden.

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Conditions

The condition(s) this trial relates to.

age-related macular degeneration choroidal neovascularization eye disorder macular degeneration nemaline myopathy retinal degeneration retinal disorder wet macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMD CNV NAMD WAMD WET AGE RELATED MACULAR DEGENERATION WETAMD

Contacts and locations

Locations

A.O.U. Consorziale Policlinico di Bari /ID# 262500

Bari, 70124, Italy
AP-HP - Groupe Hospitalier 10e - Hopital Lariboisiere /ID# 262406

Paris, 75010, France
ASL 2 Abruzzo Lanciano-Vasto-Chieti /ID# 263923

Chieti, 67100, Italy
ASST Fatebenefratelli Sacco /ID# 263273

Milan, Milano, 20157, Italy
ASU FC - P.O. Universitario Santa Maria della Misericordia /ID# 263036

Udine, 33100, Italy
Advanced Vision Research Institute /ID# 256380

Longmont, Colorado, 80503, United States
Alberta Retina Consultants /ID# 265599

Edmonton, Alberta, T5H 0X5, Canada
Asheville Eye Associates- Retina Division /ID# 256355

Asheville, North Carolina, 28803, United States
Associated Retinal Consultants /ID# 256269

Royal Oak, Michigan, 48073, United States
Austin Clinical Research, LLC /ID# 256274

Austin, Texas, 78750-2298, United States
Austin Research Center for Retina /ID# 256265

Austin, Texas, 78705, United States
Austin Retina Associates - Round Rock /ID# 256387

Round Rock, Texas, 78681, United States
Azienda Ospedaliera Universitaria Luigi Vanvitelli /ID# 264074

Naples, Napoli, 80138, Italy
Azienda Ospedaliero-Universitaria di Ferrara - Arcispedale S.Anna /ID# 262896

Cona, Ferrara, 44124, Italy
Barnet Dulaney Eye Center-Phoenix /ID# 256340

Phoenix, Arizona, 85016, United States
Bay Area Retina Associates - Walnut Creek - Lennon Lane /ID# 268513

Walnut Creek, California, 94598, United States
Black Hills Regional Eye Institute /ID# 262872

Rapid City, South Dakota, 57701, United States
Bradford Royal Infirmary /ID# 273164

Bradford, BD9 6RJ, United Kingdom
Bristol Eye Hospital /ID# 271619

Bristol, BS1 2LX, United Kingdom
Budapest Retina Intezet /ID# 262647

Budapest, 1133, Hungary
Byers Eye Institute Stanford /ID# 262853

Palo Alto, California, 94303, United States
CHU Dijon /ID# 262410

Dijon, Cote-d Or, 21000, France
CHU de Quebec-Universite Laval /ID# 258996

Québec, Quebec, G1R 2J6, Canada
Calgary Retina Consultants /ID# 258997

Calgary, Alberta, T2H 0C8, Canada
California Retina Consultants - Bakersfield /ID# 256240

Bakersfield, California, 93309-1677, United States
California Retina Consultants - Oxnard - North Ventura Road /ID# 262883

Oxnard, California, 93036, United States
Center for Retina and Macular Disease /ID# 256335

Winter Haven, Florida, 33880, United States
Centre Hosp Intercommunal de Creteil /ID# 262407

Créteil, Val-de-Marne, 94000, France
Centre Hospitalier Universitaire de Nantes, Hotel Dieu -HME /ID# 262408

Nantes, Pays de la Loire Region, 44000, France
Centre Hospitalier Universitaire de Nice - Hopital Pasteur /ID# 262418

Nice, Alpes-Maritimes, 06001, France
Charles Retina Institute /ID# 256237

Germantown, Tennessee, 38138, United States
Charleston Neuroscience Institute - Beaufort /ID# 256385

Beaufort, South Carolina, 29902-6216, United States
Charleston Neurosciences Institute /ID# 256336

Ladson, South Carolina, 29414-5896, United States
Charleston Neurosciences Institute /ID# 256351

Charleston, South Carolina, 29414-5896, United States
Chu De Toulouse - Hopital Pierre Paul Ricquet /ID# 262411

Toulouse, Occitanie, 31059, France
Cincinnati Eye Institute /ID# 256247

Cincinnati, Ohio, 45242-5664, United States
Cleveland Clinic - Cleveland /ID# 256282

Cleveland, Ohio, 44195, United States
Clinica Baviera /ID# 270146

Madrid, 28046, Spain
Clinique Honoré Cave /ID# 262225

Montauban, 82017, France
Clinique Juge /ID# 262417

Marseille, Provence-Alpes-Côte d'Azur Region, 13008, France
Colorado Retina Associates /ID# 256378

Lakewood, Colorado, 80228, United States
Columbia University of New York - Edward S. Harkness Eye Institute /ID# 256342

New York, New York, 10032, United States
Complejo Hospitalario Universitario Insular-Materno Infantil de Gran Canaria /ID# 262633

Las Palmas de Gran Canaria, Las Palmas, 35016, Spain
Complejo Hospitalario Universitario de Santiago (CHUS) /ID# 262632

Santiago de Compostela, A Coruna, 15706, Spain
Debreceni Egyetem-Klinikai Kozpont /ID# 262646

Debrecen, Hajdú-Bihar, 4032, Hungary
Duke University Medical Center /ID# 256245

Durham, North Carolina, 27710, United States
Emanuelli Research & Development Center LLC /ID# 256231

Arecibo, 00612, Puerto Rico
Envision Ocular, LLC /ID# 256367

Bloomfield, New Jersey, 07003, United States
Florida Retina Consultants /ID# 256321

Lakeland, Florida, 33805, United States
Florida Retina Institute - Orlando /ID# 256373

Orlando, Florida, 32806-1101, United States
Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Università Cattolica /ID# 263037

Rome, Roma, 00168, Italy
Fort Lauderdale Eye Institute /ID# 266011

Plantation, Florida, 33324, United States
Fukushima Medical University Hospital /ID# 258411

Fukushima, Fukushima, 960-1295, Japan
Ganglion Orvosi Központ /ID# 264550

Pécs, 7621, Hungary
Georgia Retina - Marietta /ID# 256264

Marietta, Georgia, 30060, United States
Gloucestershire Royal Hospital /ID# 277362

Gloucester, Gloucestershire, GL1 3NN, United Kingdom
Graystone Eye /ID# 256424

Hickory, North Carolina, 28602, United States
Gundersen Health System - La Crosse Medical Center /ID# 276012

La Crosse, Wisconsin, 54601, United States
Hopitaux Universitaires Paris Centre-Hopital Cochin /ID# 262415

Paris, Paris, 75679, France
Hospital Arruzafa /ID# 262634

Córdoba, Cordoba, 14012, Spain
Hospital Santa Creu i Sant Pau /ID# 262637

Barcelona, 08041, Spain
Hospital Universitari de Bellvitge /ID# 262641

L'Hospitalet de Llobregat, Barcelona, 08907, Spain
Hospital Universitario 12 de Octubre /ID# 262636

Madrid, 28041, Spain
Hospital Universitario Puerta de Hierro - Majadahonda /ID# 262635

Majadahonda, Madrid, 28222, Spain
Hyogo Medical University Hospital /ID# 257893

Nishinomiya-shi, Hyōgo, 663-8501, Japan
Hôpital de la Croix Rousse - Groupement Hospitalier Nord /ID# 262409

Lyon, Auvergne-Rhône-Alpes, 69004, France
IRCCS Fondazione G.B. Bietti per lo studio e la ricerca in Oftalmologia- ONLUS /ID# 262897

Rome, Roma, 00184, Italy
IRCCS Ospedale Sacro Cuore Don Calabria /ID# 263536

Negrar, Verona, 37024, Italy
IRCCS Ospedale San Raffaele /ID# 263035

Milan, Milano, 20132, Italy
Illinois Retina Associates - Oak Park /ID# 256375

Oak Park, Illinois, 60304, United States
Institut Clínic d'Oftalmologia (ICOF). Hospital Clínic d'Oftalmologia. /ID# 262644

Barcelona, 08028, Spain
Instituto de Microcirugía Ocular /ID# 262642

Barcelona, 08035, Spain
Jacobs Retina Center at UCSD/ID# 256320

La Jolla, California, 92093, United States
John-Kenyon American Eye Institute -New Albany /ID# 256283

New Albany, Indiana, 47150, United States
Johns Hopkins Hospital /ID# 256236

Baltimore, Maryland, 21287, United States
Juntendo University Hospital /ID# 258715

Bunkyo-ku, Tokyo, 113-8431, Japan
Kagoshima University Hospital /ID# 257053

Kagoshima, Kagoshima-ken, 890-8520, Japan
Kaiser Permanente - Riverside Medical Center /ID# 262413

Riverside, California, 92505, United States
Klinikum Ludwigshafen /ID# 262497

Ludwigshafen am Rhein, Rhineland-Palatinate, 67063, Germany
Knappschaftsklinikum Saar /ID# 262496

Püttlingen, 66346, Germany
Kobe City Eye Hospital /ID# 256948

Kobe, Hyōgo, 650-0047, Japan
Kyoto University Hospital /ID# 267351

Kyoto, Kyoto, 606-8507, Japan
Leeds Teaching Hospital /ID# 277366

Leeds, West Yorkshire, LS9 7TF, United Kingdom
Liverpool University Hospitals NHS Foundation Trust /ID# 262305

Liverpool, L7 8XP, United Kingdom
MA Eye & Ear Infirmary /ID# 262430

Boston, Massachusetts, 02114, United States
Macula Retina Vitreous Center - Torrance /ID# 270247

Torrance, California, 90503, United States
Maine Eye Center - Marginal Way Campus /ID# 256391

Portland, Maine, 04101, United States
Manchester University NHS Foundation Trust /ID# 262404

Manchester, M9 2AA, United Kingdom
Mayo Clinic - Rochester /ID# 258295

Rochester, Minnesota, 55905-0001, United States
Mid America Surgery Center /ID# 258993

Chesterfield, Missouri, 63017, United States
Mid Atlantic Retina /ID# 256232

Philadelphia, Pennsylvania, 19107, United States
Mid Atlantic Retina Specialists - Hagerstown /ID# 256310

Hagerstown, Maryland, 21740-5965, United States
Midwest Retina /ID# 276644

Dublin, Ohio, 43016, United States
Mississippi Retina Associates /ID# 270934

Madison, Mississippi, 39110-2028, United States
Monmouth Retina Consultants /ID# 275895

Little Silver, New Jersey, 07739, United States
Moorfields Eye Hospital /ID# 263038

London, Greater London, EC1V 2PD, United Kingdom
Nagoya University Hospital /ID# 267350

Nagoya, Aichi-ken, 466-8560, Japan
National Ophthalmic Research Institute /ID# 256344

Fort Myers, Florida, 33912-7125, United States
Northwestern Memorial Hospital - Department of Ophthalmology /ID# 256379

Chicago, Illinois, 60611-2987, United States
Ohio State University /ID# 256275

Columbus, Ohio, 43210, United States
Ophthalmic Consultants of Boston /ID# 256233

Boston, Massachusetts, 02114, United States
Orange County Retina Medical Group /ID# 256286

Santa Ana, California, 92705, United States
Ottawa Hospital Research Institute /ID# 258998

Ottawa, Ontario, K1H 8L6, Canada
Oxford University Hospitals NHS Foundation Trust /ID# 262306

Oxford, Oxfordshire, OX3 9DU, United Kingdom
Pacific Northwest Retina /ID# 258999

Bellevue, Washington, 98004, United States
Palmetto Retina Center-Florence /ID# 256244

Florence, South Carolina, 29501, United States
Piedmont Eye Center /ID# 256386

Lynchburg, Virginia, 24502, United States
Rand Eye Institute /ID# 256337

Deerfield Beach, Florida, 33064, United States
Retina Associates - Lenexa /ID# 258296

Lenexa, Kansas, 66215, United States
Retina Associates of Cleveland-Middleburg Heights /ID# 256280

Cleveland, Ohio, 44130, United States
Retina Associates of Michigan /ID# 256393

Grand Blanc, Michigan, 48439, United States
Retina Associates of South Texas

San Antonio, Texas, 78240, United States
Retina Associates of Utah /ID# 256276

Salt Lake City, Utah, 84107, United States
Retina Associates of Western New York /ID# 256374

Rochester, New York, 14620, United States
Retina Center NW, PLLC /ID# 256395

Silverdale, Washington, 98383, United States
Retina Center Of Texas (Rct) - Southlake /ID# 256281

Southlake, Texas, 76092, United States
Retina Centre of Ottawa /ID# 259659

Ottawa, Ontario, K2B 7E9, Canada
Retina Consultants of Hawaii /ID# 256278

‘Aiea, Hawaii, 96701, United States
Retina Consultants of Orange County /ID# 256267

Fullerton, California, 92835, United States
Retina Consultants of San Diego /ID# 256258

Poway, California, 92064-2530, United States
Retina Consultants of Southern Colorado /ID# 256285

Colorado Springs, Colorado, 80909, United States
Retina Consultants of Texas - Bellaire /ID# 256377

Bellaire, Texas, 77401, United States
Retina Consultants of Texas /ID# 256382

San Antonio, Texas, 78251, United States
Retina Consultants of Texas/ID# 259661

San Antonio, Texas, 78240-1655, United States
Retina Consultants, P.C. /ID# 273610

Manchester, Connecticut, 06042-3556, United States
Retina Institute of Virginia /ID# 256394

Richmond, Virginia, 23235, United States
Retina Macula Institute of Arizona /ID# 271026

Scottsdale, Arizona, 85255-4134, United States
Retina Partners Midwest, PC /ID# 256277

Indianapolis, Indiana, 46290, United States
Retina Research Institute of Texas /ID# 256263

Abilene, Texas, 79606-1224, United States
Retina Specialists /ID# 256392

Baltimore, Maryland, 21204, United States
Retina Specialty Institute /ID# 256268

Pensacola, Florida, 32503, United States
Retina Surgical Associates /ID# 270958

New Westminster, British Columbia, V3L 5H1, Canada
Retina Vitreous Assoc Med Grp /ID# 256246

Beverly Hills, California, 90211, United States
Retina Vitreous Associates of Florida - St. Petersburg /ID# 256279

St. Petersburg, Florida, 33711-1141, United States
Retina Vitreous Center, Research /ID# 256284

Edmond, Oklahoma, 73013, United States
Retinal Consultants Medical Group, Inc. - Greenback /ID# 256353

Sacramento, California, 95841, United States
Retinal Diagnostic Center /ID# 256262

Campbell, California, 95008, United States
Retinal Research Institute /ID# 256238

Phoenix, Arizona, 85053, United States
Rocky Mountain Retina Consultants /ID# 256369

Murray, Utah, 84107, United States
Royal Victoria Infirmary /ID# 277368

Newcastle upon Tyne, NE1 4LP, United Kingdom
Shiga University of Medical Science /ID# 266862

Ōtsu, Shiga, 520-2192, Japan
Sierra Eye Associates /ID# 256239

Reno, Nevada, 89502, United States
Southeastern Retina Associates - Chattanooga /ID# 258992

Chattanooga, Tennessee, 37421, United States
Southeastern Retina Associates - Johnson City /ID# 256396

Johnson City, Tennessee, 37604, United States
Southwest Retina Research Center /ID# 256261

Durango, Colorado, 81303, United States
Spokane Eye Clinic /ID# 256338

Spokane, Washington, 99204, United States
Springfield Clinic - First /ID# 256371

Springfield, Illinois, 62702, United States
Star Retina - Burleson /ID# 256376

Burleson, Texas, 76028, United States
Stoke Mandeville Hospital /ID# 277343

Aylesbury, Buckinghamshire, HP21 8AL, United Kingdom
Sunderland Eye Infirmary /ID# 271620

Sunderland, SR2 9HP, United Kingdom
Sunnybrook Research Institute /ID# 270690

Toronto, Ontario, M4N 3M5, Canada
Tennessee Retina - Nashville /ID# 256388

Nashville, Tennessee, 37203-1513, United States
Texas Retina Associates - Fort Worth /ID# 256326

Fort Worth, Texas, 76104, United States
Texas Retina Associates /ID# 256259

Dallas, Texas, 75231, United States
The Retina Clinic London /ID# 262304

London, Greater London, W1G 7LB, United Kingdom
The Retina Partners - Encino /ID# 259660

Encino, California, 91436, United States
Toronto Retina Institute /ID# 265602

Toronto, Ontario, M3C 0G9, Canada
UC Davis Health Eye Center

Sacramento, California, 95817, United States
Universitaetsklinikum Bonn /ID# 262498

Bonn, North Rhine-Westphalia, 53127, Germany
Universitaetsklinikum Freiburg /ID# 262495

Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
Universitaetsklinikum Hamburg-Eppendorf /ID# 262493

Hamburg, 20246, Germany
Universitaetsklinikum Muenster /ID# 262499

Münster, North Rhine-Westphalia, 48149, Germany
Universitaetsklinikum Ulm /ID# 262494

Ulm, Baden-Wurttemberg, 89081, Germany
University Hospital Southampton NHS Foundation Trust /ID# 262307

Southampton, Hampshire, SO16 6YD, United Kingdom
University Retina and Macula Associates /ID# 256287

Oak Forest, Illinois, 60452, United States
University Retina and Macula Associates /ID# 256288

Lemont, Illinois, 60439, United States
University of British Columbia - Eye Care Centre, Vancouver General Hospital /ID# 266014

Vancouver, British Columbia, V5Z 3N9, Canada
University of Missouri Hospital /ID# 262474

Columbia, Missouri, 65212, United States
University of Miyazaki Hospital /ID# 262879

Miyazaki, Miyazaki, 889-1692, Japan
University of Pennsylvania /ID# 258995

Philadelphia, Pennsylvania, 19104-5502, United States
University of Pittsburgh Medical Center /ID# 258994

Pittsburgh, Pennsylvania, 15213, United States
Vanderbilt University Medical Center /ID# 256372

Nashville, Tennessee, 37232-0011, United States
Vistar Eye Center /ID# 271024

Roanoke, Virginia, 24019, United States
Vitreo Retinal Associates - Worcester /ID# 266008

Worcester, Massachusetts, 01605, United States
VitreoRetinal Surgery PLLC DBA Retina Consultants of Minnesota /ID# 256272

Edina, Minnesota, 55435, United States
Vitreoretinal Associates, P.A. /ID# 256266

Gainesville, Florida, 32607, United States
Vitreous Retina Macula Specialists of Toronto /ID# 258299

Etobicoke, Ontario, M8X 2X3, Canada
Wagner Kapoor Research Institute - Norfolk /ID# 256260

Norfolk, Virginia, 23502, United States
Washington University School of Medicine - St. Louis /ID# 256383

St Louis, Missouri, 63108, United States
Western Eye Hospital /ID# 271621

London, England, NW1 5QH, United Kingdom
Wolfe Eye Clinic - West Des Moines /ID# 256314

West Des Moines, Iowa, 50266, United States

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