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Blood-Derived gel may supercharge gum disease treatment

NCT ID NCT07696845

Disease control Sponsor: Altinbas University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 10, 2026 · Last updated Aug 20, 2026 · Updated 3 times

Summary

This study tests whether adding concentrated platelet-rich fibrin (C-PRF), a gel made from a patient's own blood, to a minimally invasive non-surgical gum treatment can improve healing in people with advanced periodontitis. Thirty adults with severe gum disease and deep bone defects receive either the standard treatment alone or combined with C-PRF. Researchers measure changes in pocket depth, gum attachment, and bone fill over six months to see if the addition of C-PRF provides extra benefits.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
concentrated platelet-rich fibrin (C-PRF)
What this could lead to
If it works, this could offer a better way to treat advanced gum disease without surgery, potentially saving more teeth.
What could go wrong
This is a small, early-stage study with only 30 participants, so results may not apply to everyone. The added benefit of C-PRF over standard care is uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Aug 2026

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Individuals aged 18 to 70 years. * Systemically healthy individuals. * Individuals diagnosed with Stage III or Stage IV periodontitis. * Presence of at least one periodontal intrabony defect with a radiographic intrabony defect depth of ≥3 mm. * Presence of probing pocket depth of ≥6 mm at the selected defect site. * No periapical pathology associated with the selected tooth. Exclusion Criteria: * Pregnancy or lactation. * Presence of systemic diseases or use of medications that may affect periodontal healing. * Periodontal treatment within the recent period before enrollment. * Smoking ≥10 cigarettes per day. * Presence of periapical pathology associated with the selected tooth.

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Conditions

The condition(s) this trial relates to.

periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Intrabony periodontal defect Non surgical periodontal treatment Periodontitis

Contacts and locations

Locations

  • Altınbaş University Faculty of Dentistry, Department of Periodontology

    Istanbul, Bakırkoy, 34147, Turkey (Türkiye)

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