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Blood-Derived gel may supercharge gum disease treatment

NCT ID NCT07696845

Completed Disease control Sponsor: Altinbas University Source: ClinicalTrials.gov ↗

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This study tests whether adding concentrated platelet-rich fibrin (C-PRF), a gel made from a patient's own blood, to a minimally invasive non-surgical gum treatment can improve healing in people with advanced periodontitis. Thirty adults with severe gum disease and deep bone defects receive either the standard treatment alone or combined with C-PRF. Researchers measure changes in pocket depth, gum attachment, and bone fill over six months to see if the addition of C-PRF provides extra benefits.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
concentrated platelet-rich fibrin (C-PRF)
What this could lead to
If it works, this could offer a better way to treat advanced gum disease without surgery, potentially saving more teeth.
What could go wrong
This is a small, early-stage study with only 30 participants, so results may not apply to everyone. The added benefit of C-PRF over standard care is uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INTRABONY PERIODONTAL DEFECT NON SURGICAL PERIODONTAL TREATMENT PERIODONTITIS

Contacts and locations

Locations

  • Altınbaş University Faculty of Dentistry, Department of Periodontology

    Istanbul, Bakırkoy, 34147, Turkey (Türkiye)

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