New transplant method aims to reduce complications in bone marrow failure patients
NCT ID NCT03047746
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a stem cell transplant method for people with acquired or inherited bone marrow failure. Donor stem cells are specially processed to remove certain immune cells, which may lower the risk of graft rejection and graft-versus-host disease. The goal is to see if this approach improves engraftment and survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- TCR alpha/beta T cell-depleted peripheral blood stem cells
- What this could lead to
- If successful, this approach could provide a safer transplant option for patients with bone marrow failure, reducing risks of graft failure and graft-versus-host disease.
- What could go wrong
- This is an early pilot study with a small number of participants. Risks include graft failure, infections, and graft-versus-host disease despite the cell depletion.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ACQUIRED APLASTIC ANEMIA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A pill that could replace infusions for a rare blood disease?
- Can a single drink reveal how alcohol triggers oral cancer?
- Every-8-Week shot could simplify PNH treatment
- Real-World test: can a targeted drug keep PNH in check for years?
- Gene therapy aims to fix bone marrow failure in fanconi anemia
- No treatment, just observation: large study looks at PNH blood cells