Musculoskeletal system disorder

This trial is testing a new type of immune cell therapy called CD123 CAR-NK cells in people with relapsed or refractory acute myeloid leukemia (AML) or blastic plasmacytoid dendritic cell neoplasm (BPDCN). The cells are designed to find and attack cancer cells that carry a protei…

This trial is for adults with relapsed or refractory acute myeloid leukemia (AML) who have no standard curative options. Researchers are testing whether giving the drug gemtuzumab ozogamicin followed by an infusion of donor white blood cells can stimulate the immune system to att…

This study tests a personalized vaccine made from a patient's own leukemia cells fused with immune cells, combined with a drug that blocks PD-1, to help the immune system recognize and destroy any remaining leukemia cells after chemotherapy. The goal is to prevent the cancer from…

This trial investigates whether non-surgical gum treatment can improve early signs of blood vessel dysfunction in people with periodontitis who have no known heart disease. Sixty participants will receive one of two types of deep cleaning procedures. Researchers will measure chan…

This Phase 3 trial tests whether TAS-205, an oral drug, can improve movement and safety in people with Duchenne muscular dystrophy. It includes 104 participants, both those who can walk and those who cannot. The study compares TAS-205 to a placebo over 52 weeks.

This trial tests whether rinsing with coconut oil can reduce plaque and gum inflammation as effectively as a standard chlorhexidine mouthwash. Eighty adults with plaque-induced gingivitis will be split into two groups: one using coconut oil daily and the other using chlorhexidine…

This study is testing whether applying a silver diamine fluoride gel followed by a fluoride varnish can stop cavities in children's baby teeth. Researchers will follow 237 children for a year to see how many cavities become inactive and whether parents are satisfied with the trea…

This early-phase trial tested whether giving patients their own natural killer (NK) cells, boosted by the drug bortezomib, is safe for treating advanced cancers like leukemia, lung, and pancreatic cancer. Thirty-five adults whose cancers had not responded to standard treatments r…

This phase III trial is testing whether taking oral azacitidine as a maintenance therapy after an allogeneic stem cell transplant can help prevent relapse in people with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). Participants are randomly assigned to receive…

This trial tests whether adding structured telemonitoring—weekly text messages and video calls—to standard conservative care helps people with temporomandibular disorder (TMD)-related jaw pain. Participants receive behavioral counseling, habit reversal training, and home exercise…

This early study tests an implanted device called the Intelligent Spine Interface (ISI-C) in people with spinal cord injuries. The device is designed to bridge the gap in the spinal cord, picking up signals from above the injury and sending them to nerves below. The goal is to un…

This study compares two supervised exercise programs—motor control retraining and close kinetic chain exercises—to see which better reduces pain, improves knee function, and strengthens a key thigh muscle in people with patellofemoral pain syndrome (pain around the kneecap). Fift…

This study tests whether the oral drug upadacitinib works better than the injected drug adalimumab for adults with moderate to severe rheumatoid arthritis who still have symptoms after trying one TNF blocker. About 480 participants will be randomly assigned to receive either upad…

This trial tests whether herbal mouthwashes containing tea tree oil, thyme hydrosol, or essential oils can reduce the plaque and gum inflammation seen in gingivitis. About 52 adults with gingivitis will use one of these mouthwashes or a placebo twice daily for three months, along…

This phase 1 trial is testing an investigational drug called AEB1102 in adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that has returned or stopped responding to standard treatments. AEB1102 is a modified human enzyme that breaks down arginine, an amin…

This trial tests a new, less invasive surgical approach for treating advanced periodontitis (stage III). Instead of lifting the gum, doctors access the damaged bone through a small pinhole, clean the area, and place a bone graft to encourage regeneration. The study includes adult…

This trial tests two gentler ways to treat cavities in children's baby molars: the Hall technique, which fits a stainless steel crown without removing decay, and atraumatic restorative treatment (ART), which uses hand tools and adhesive fillings. It compares these to the conventi…

This study compares two popular mouthwashes, Listerine and Chlorhexidine, to see which better controls gum inflammation and plaque in people undergoing orthodontic treatment with braces. Sixty participants aged 13-40 will use one of the rinses and be checked at 2 and 4 weeks. The…

This Phase 3b study is testing whether the drug benralizumab (Fasenra) can allow people with severe eosinophilic asthma to safely reduce their daily maintenance medications. About 504 participants aged 12-75 in China will try to step down from drugs like inhaled steroids or long-…

This study tests a drug called TQH2722, a lab-made antibody that blocks inflammation, for people with severe chronic sinusitis (with or without nasal polyps). About 120 adults who completed a prior TQH2722 study will receive either 300mg or 600mg injections over a long period. Re…

This trial tests whether giving a fluorescent dye called indocyanine green during endoscopic surgery helps surgeons remove non-functioning pituitary macroadenomas more completely. About 34 adults with these tumors will be randomly assigned to receive the dye or not during surgery…

This study looked at whether people with chronic myeloid leukemia (CML) who have done very well on the drug nilotinib can safely stop taking it. 215 patients who had been on nilotinib for at least two years and had very low levels of cancer cells were enrolled. The main goal was …

This study tests whether doing a gum graft at the same time as placing a dental implant works as well as the traditional two-step approach. The goal is to increase the width of keratinized gum tissue around implants, which helps prevent inflammation and implant failure. Twenty-tw…

This trial is testing whether a chemotherapy drug called treosulfan, given in different doses along with fludarabine, can safely prepare patients with advanced blood cancers for a stem cell transplant. The study focuses on patients who are not eligible for the standard, more inte…

This trial tests whether a specialized three-dimensional corrective exercise program can slow or stop the progression of mild-to-moderate idiopathic scoliosis in children and teens aged 8–16. Participants are split into two groups: one performs the 3D corrective exercises (with a…

This trial asks whether a newer filling material called zirconomer holds up better than a standard glass ionomer cement when repairing cavities in children's baby molars. About 30 children aged 5 to 7 with a cavity in a back baby tooth will receive one of the two fillings. Resear…

This trial compares two surgical approaches for total hip replacement: the minimally invasive SuperPATH technique and the conventional posterior approach. Adults with hip arthritis or related conditions are randomly assigned to one of the two procedures. The study tracks recovery…

This trial tests three types of tooth-colored fillings in children's baby molars to see which performs best. It compares a preheated bulk-fill composite with two indirect composite systems, looking at how well they hold up, how they look, and whether they cause any problems. The …

This study looked at whether people with chronic myeloid leukemia (CML) who had very low levels of cancer cells could safely stop taking the drug nilotinib (Tasigna). Participants had already been treated with imatinib (Gleevec) and then nilotinib for at least 3 years. The main g…

This early-stage trial tests a combination of two drugs, venetoclax and azacitidine, in people with a serious type of myelodysplastic syndromes (MDS) who have not had treatment before. The goal is to find the safest dose and see how well the drugs work together to control the dis…

This early-phase trial tests the safety and tolerability of a new drug called GRT6019 in 24 healthy men. Participants receive multiple doses over 4 weeks and are monitored for side effects and how the drug moves through the body. The goal is to see if GRT6019 is safe enough to st…

This trial compares giving zoledronate, a yearly intravenous bone-strengthening drug, within 5 days of hip fracture surgery versus waiting 3 months. The goal is to see if early treatment is as safe and effective at reducing bone turnover and preventing future fractures. Participa…

This trial tests whether propolis, a natural resin from bees, can control bleeding during a tooth-saving procedure called full pulpotomy for adults with painful, inflamed molars. Participants are randomly assigned to receive propolis or the standard sodium hypochlorite as a hemos…

This trial tests whether using artificial intelligence and computer guidance to lift the sinus floor and place dental implants immediately, along with a graft made from the patient's own tooth, improves outcomes compared to the traditional free-hand method. The study includes peo…

This trial tests whether a mouthwash containing chlorhexidine and sodium DNA can better control bacterial biofilm in people with advanced periodontitis (stage III or IV). Participants will receive standard non-surgical gum treatment plus one of two mouthwashes or a placebo, and r…

This trial is testing an experimental drug called BST-236 in adults with acute myeloid leukemia (AML) or high-risk myelodysplastic syndromes (MDS) that have come back or not improved after initial treatment. Participants receive BST-236 as a one-hour intravenous infusion for six …

This study looked at whether a custom-made hip spacer can help people with infected hip replacements. 25 patients had their infected hip implant removed and replaced with a temporary custom spacer, followed by antibiotics. After the infection cleared, they received a new permanen…

This trial tests whether adding a posterior column osteotomy—a small cut in the spinal joints—during standard scoliosis surgery improves spine straightening in adolescents. Half of the participants will receive the extra procedure, and half will not. The study measures curve corr…

This study compares two types of tooth-colored fillings—alkasite and glass ionomer—for cavities in baby molars. Children aged 5 to 7 with decayed molars will receive one of the two materials, and the fillings will be checked over time for signs of new decay, color match, and how …

This trial tests whether a daily bioactive collagen peptide supplement can improve knee pain, stiffness, and physical function in adults with mild to moderate knee osteoarthritis. Participants are randomly assigned to take either the collagen supplement or a glucosamine and chond…

This phase 2 trial is testing an experimental drug called TransCon CNP in children with achondroplasia, a common form of dwarfism. The study aims to see if a once-weekly injection under the skin can safely improve growth, measured by height velocity over a year. Participants will…

This early-phase trial tests a new type of immunotherapy for people who develop a rare blood cancer called post-transplant lymphoproliferative disease (PTLD) after a solid organ transplant. The treatment uses the patient's own immune cells (T-cells) that are engineered to resist …

This phase II trial investigates whether eltrombopag, a drug that stimulates platelet production, can help older adults with acute myeloid leukemia (AML) recover their platelet counts faster after initial chemotherapy. Older patients often experience slow platelet recovery, which…

This trial tests whether an experimental biosimilar called 9MW0311 works as well as the established drug Prolia (both containing denosumab) in postmenopausal women with osteoporosis who are at high risk for fractures. Participants receive either 9MW0311 or Prolia as an injection …

This trial tests whether photoactivated disinfection (using a light-activated dye) or Er,Cr:YSGG laser disinfection can better clean infected tooth sockets before placing an immediate dental implant, compared to standard chlorhexidine rinsing. The goal is to see which method lead…

This trial compares two types of surgical tools used during total hip replacement: single-use (disposable) reaming instruments and conventional reusable ones. The main focus is on the overall cost of surgery, including sterilization, materials, and operating room time. Researcher…

This phase 2 trial is testing whether a combination of two drugs, venetoclax and azacitidine, can effectively treat adults aged 18 to 59 who have been newly diagnosed with acute myeloid leukemia (AML) and have not yet received any treatment. Participants take both drugs in cycles…

This trial tests three different injection combinations for people with a painful jaw joint condition called TMJ internal derangement. Participants receive one injection of hyaluronic acid mixed with either platelet-rich plasma, tenoxicam, or a corticosteroid. The study measures …

This trial is testing whether daily injections of recombinant human growth hormone can improve growth in children with achondroplasia, a genetic condition that causes short stature. The study will include children aged 2 to 10 who have not previously been treated with growth horm…

This study looked at whether adding virtual reality games to standard scoliosis exercises helps teenagers with curved spines. Twenty teens aged 10-15 with moderate scoliosis took part. Half did regular exercises, and the other half also played virtual reality games for balance an…

This trial investigates whether using a socket sealing abutment, with or without bone graft material, helps preserve bone and soft tissue after immediate molar implant placement. Adults aged 18-45 with non-restorable molars will receive the implant right after extraction, and the…

This trial looks at whether children with juvenile spondyloarthritis who have stable, inactive disease can safely reduce or stop their TNFi medication without causing a flare. Participants are randomly assigned to continue their usual TNFi dose, take it less frequently, or stop i…

This trial tests whether a spinal implant that delivers electrical stimulation, combined with robot-assisted rehabilitation, can improve walking ability in people with chronic spinal cord injury. Participants will have a device implanted and then undergo months of training. The g…

This trial tests whether a zero-profile anchored cage, used in anterior cervical discectomy and fusion, can improve outcomes for people with cervical degenerative disc disease. The study will enroll 30 adults aged 18-70 who have not had prior cervical spine surgery and whose symp…

This study tests a new toothpaste with stannous fluoride to see if it improves gum health and reduces plaque better than regular fluoride toothpaste. About 300 adults with mild to moderate gum inflammation will brush with the test toothpaste for 24 weeks. Researchers will measure…

This trial tests whether physiotherapeutic scoliosis specific exercises (PSSE) can halt the progression of mild adolescent idiopathic scoliosis, a condition where the spine curves sideways. About 42 teens aged 10-16 with a curve under 20 degrees will be randomly assigned to eithe…

This trial tests whether a specialized 3D exercise program can slow or reduce spine curvature in adolescents with mild idiopathic scoliosis. Participants aged 10-16 with curves between 10-20 degrees will be randomly assigned to either the exercise program or standard observation.…

This pilot trial is asking whether injecting magnesium sulfate into the jaw joint after a standard washout procedure (arthrocentesis) can reduce pain and improve jaw function better than the usual treatments. It compares magnesium sulfate against hyaluronic acid (a common injecti…

This trial is testing an experimental oral drug called PXS-5505 (amsulostat) in people with myelofibrosis, a type of bone marrow cancer. The study focuses on patients who are not eligible for a stem cell transplant. The main goal is to see if the drug is safe and tolerable, and t…

This trial tests whether a three-tone plaque-disclosing gel, which stains old and new plaque in different colors, can help people with gingivitis clean their teeth more effectively than standard brushing instructions alone. Sixty-four adults with gingivitis will be randomly assig…

This study tests whether a gel made from cross-linked hyaluronic acid (Hyadent BG®) can help regrow bone and gum tissue destroyed by chronic gum disease, comparing it to a standard treatment called Emdogain®. About 53 adults with moderate periodontitis will receive one of the two…

This trial asks whether a telerehabilitation program—guided exercises done at home—can reduce shoulder pain and disability as effectively as traditional in-person physiotherapy. Adults aged 18 to 60 with persistent shoulder pain lasting at least three months are randomly assigned…

This trial tests different combinations of biomaterials used during gum surgery to treat class II furcation defects—areas where bone loss has occurred between the roots of molars. The goal is to see which combination best encourages bone regrowth and improves gum thickness. Adult…

This trial tests whether epicatechin, a compound naturally found in dark chocolate, can counteract the muscle-related side effects caused by statins, a common cholesterol-lowering medication. Participants with statin intolerance will receive epicatechin or a placebo, and research…

This trial tests whether applying a liquid growth factor solution (LPCGF) to the tooth root during standard gum graft surgery can improve gum thickness and coverage. Twenty adults with receding gums will receive either the standard treatment or the standard treatment plus LPCGF. …

This trial tests whether dupilumab, an injectable drug that blocks certain inflammatory signals, can reduce sinus swelling and improve symptoms like loss of smell and runny nose in adults with chronic sinusitis who do not have nasal polyps. Participants receive either dupilumab o…

This trial tests whether coating a dental implant with a gel made from fucoidan — a compound from brown seaweed — can improve wound healing and bone regrowth compared to standard implant placement. Twenty adults with early-stage gum disease who need a tooth replaced will receive …

This trial tests whether photodynamic therapy (PDT) using methylene blue can control early-stage pericoronitis, a painful gum infection around partially erupted wisdom teeth. Thirty-four healthy young adults with early pericoronitis will receive either standard irrigation or PDT,…

This trial tests whether a calcium silicate cement outperforms the standard calcium hydroxide material when used to treat deep cavities close to the tooth's nerve. Adults aged 18 to 45 with at least one deep cavity will receive one of the two materials after partial decay removal…

This trial tests whether treating gum disease can reduce bacteria that cause lung infections in people with bronchiectasis. Participants with both conditions will receive either basic cleaning, deep cleaning, or deep cleaning plus light therapy. Researchers will measure bacteria …

This study compares two types of dental implants in people who need a short-span fixed bridge (fewer than four implants). One implant has a lateralized design intended to preserve the crestal bone around it, while the other is a standard version. The goal is to see whether the la…

This trial tests whether adding an interdental brush, water flosser, or rubber toothpick to twice-daily toothbrushing reduces plaque and gum bleeding more than brushing alone. Twenty-nine dental students with gingivitis will use each method in different sections of their mouth fo…

This study tests whether a combination of injectable platelet-rich fibrin (I-PRF) and a collagen membrane can improve coverage of receding gums. The trial includes adults with Miller Class II gum recession, a condition where the gum margin has moved away from the tooth. Participa…

This trial tests whether short dental implants can work as well as standard implants placed after sinus surgery for people with limited bone height in the upper back jaw. Participants have partial tooth loss and a shallow sinus floor that would normally require a sinus lift proce…

This trial tests whether a plastic meniscus implant can outperform non-surgical treatments for people with persistent knee pain after a partial meniscus removal. Participants who had the surgery more than six months ago and are between 30 and 75 years old are randomly assigned to…

This phase 3 trial tests whether Jinhua Qinggan Granules, a traditional Chinese herbal medicine, can eliminate symptoms of acute upper respiratory infections (like fever, sore throat, and congestion) within three days. About 273 adults with early-stage cold or flu will receive ei…

This pilot study tests whether laparoscopic sleeve gastrectomy, a weight-loss surgery, can reduce markers of inflammation in saliva and improve gum health in adults with both obesity and periodontitis (gum disease). Participants are randomly assigned to either surgery or non-surg…

This trial compares two types of dental implant surfaces—Nanotite and Osseotite—to see which one integrates more successfully when placed by graduate students learning implant surgery. The study includes adults who already need dental implants for missing teeth. The goal is to fi…

This study looks at whether a specific dental implant can hold a temporary bridge right after being placed, so patients don't have to wait months for a permanent restoration. Researchers will follow 75 adults with missing back teeth who need a short bridge. The main question is w…

This trial tests whether a dental implant with a special lateralized design (Osseotite Certain Prevail) preserves more bone around the implant than a standard version. About 100 adults who need a short fixed bridge to replace missing teeth will receive one of the two implant type…

This study tracks about 450 adults with active psoriatic arthritis who are prescribed upadacitinib (RINVOQ) by their doctor. Researchers will follow participants for up to 24 months to see how well the drug controls joint and skin symptoms when used alone or with methotrexate in …

This trial is testing the long-term safety and tolerability of the drug filgotinib in people with rheumatoid arthritis who have already completed an earlier filgotinib study. Researchers are monitoring side effects, lab abnormalities, and vital signs over an extended period. The …

This pilot study tests whether micro-needling, combined with a gum-lifting procedure, can thicken receding gums as well as a standard gum graft substitute (Alloderm). Twenty-four adults with at least 3 mm of gum recession on a front tooth will receive one of the two treatments. T…

This trial tests whether using a perioscope — a tiny camera that lets dentists see below the gumline — makes deep cleaning more effective for people with periodontitis. About 26 adults with moderate to advanced gum disease will receive either standard deep cleaning or cleaning gu…

This study looks at two surgical options for people with stage II Kümmell's disease, a condition where a spinal bone collapses after a minor injury. Researchers are comparing standard vertebroplasty (injecting bone cement) against a newer method that combines cement with small sc…

This trial tests whether a brief vocational rehabilitation program can help people with arthritis who are worried about losing their jobs. Participants, all currently employed and living or working in eastern Massachusetts, will work with a physical or occupational therapist to i…

This trial tests whether efgartigimod, an injected drug that blocks certain immune antibodies, can improve muscle strength and function in adults with active idiopathic inflammatory myopathy — a group of rare autoimmune diseases that cause muscle inflammation and weakness. About …

This trial tests whether adding a clinical pharmacist to standard drug therapy helps people with early rheumatoid arthritis achieve better disease control. Participants receive pharmacist-led education, counseling, and medication management alongside their usual DMARD treatment. …

This trial investigates whether two common osteoporosis medications, denosumab and alendronate, can reduce liver fat and scarring in postmenopausal women who also have nonalcoholic fatty liver disease (NAFLD). The study will compare changes in liver fat and stiffness over 12 mont…

Osteoporosis weakens bones and raises fracture risk, but the best exercise for building bone is unclear. This trial tests two supervised strength-training programs in adults aged 50 and older with low bone density. One group lifts at a moderate intensity (70% of their max), the o…

This study tests a custom helmet fitted with temperature and pressure sensors to monitor how long and how well it is worn by infants being treated for flat head syndrome (plagiocephaly or brachycephaly). The goal is to see if the sensors can accurately track wear time and detect …

This trial investigates whether a single injection of platelet-rich plasma (PRP), made from a person's own blood, can reduce pain and improve function in chronic patellar tendinopathy (knee tendon pain). The study includes 29 adults aged 18–65 who have had tendon pain for over th…

This trial investigates whether people with knee osteoarthritis who also have a bowleg deformity (tibia vara) experience different pain relief after a partial knee replacement compared to those without the deformity. The study will measure medial knee pain using a standard pain s…

This trial investigates whether placing a kaolin-based clotting gauze inside the knee joint, combined with an intravenous dose of tranexamic acid, can reduce total blood loss during total knee replacement. About 140 adults with advanced knee osteoarthritis will be randomly assign…

This study tests whether toothpaste containing arginine, an amino acid, can prevent cavities in children aged 10 to 14. Participants brush twice daily with one of three strengths of arginine toothpaste or a standard fluoride toothpaste for one year. Researchers measure new caviti…

This study tests whether epidural electrical stimulation, combined with a structured rehabilitation program, can improve functional independence in people with spinal cord injury affecting the conus region. Participants receive an implanted stimulator and undergo task-oriented ex…

This study tests whether adding blood flow restriction training (BFRT) to standard exercise can improve pain, function, and quality of life in people with tennis elbow. BFRT uses a cuff around the upper arm to partially restrict blood flow during low-load exercises, aiming to mim…

This phase 2 trial tests an experimental drug called JS005 in adults with active ankylosing spondylitis, a type of arthritis that mainly affects the spine. Participants receive different doses of JS005 or a placebo as a shot under the skin. The study measures whether JS005 improv…

This study compares a new single-shade tooth-colored filling material, Omnichroma, to a standard multi-shade filling in children aged 3 to 5 years who have cavities in both upper front teeth. The goal is to see if the one-shade material can match the color of the surrounding toot…

This study looks at whether adding a statin (atorvastatin or rosuvastatin) to standard osteoporosis treatment can improve bone density in postmenopausal women. Participants are women aged 55 and older with osteoporosis who also have high cholesterol. The trial compares standard t…

This trial compares three different knee replacement implants—Journey II, Stryker Triathlon, and Zimmer Persona—in people aged 50 to 75 with knee osteoarthritis. Researchers measure how well each implant restores knee movement, walking patterns, and function after surgery. The go…

This study tests whether a substance produced by umbilical cord cells can help control moderate rheumatoid arthritis. Participants receive weekly injections of either the cell substance or a placebo for six weeks, alongside their usual medication. The goal is to see if it improve…

This trial compares different bioactive restorative materials and placement techniques to see how they affect the health of the tooth's pulp (nerve) after treating deep cavities. Researchers will measure inflammatory markers in the fluid around the tooth and track post-treatment …

This trial tests whether a liquid called silver diamine fluoride (SDF) can stop early cavities in molars as effectively as the standard treatment, a plastic coating called fissure sealant. Adults aged 20 to 45 with early, non-cavitated cavities will be randomly assigned to receiv…

This phase 3 trial tests whether risankizumab, an injectable biologic, can reduce joint pain and swelling in adults with moderately to severely active psoriatic arthritis who have not responded to or cannot tolerate other biologic treatments. Participants receive either risankizu…

This phase 2 trial tests an experimental drug called JS005 in adults with active ankylosing spondylitis, a type of arthritis that mainly affects the spine. JS005 is a lab-made antibody that blocks IL-17A, a protein involved in inflammation. The study compares JS005 injections to …

This study tests whether adding the targeted drug venetoclax to standard chemotherapy helps more adults with acute myeloid leukemia (AML) achieve remission. It enrolls people aged 18 to 65 with intermediate- or high-risk AML who have not yet been treated. The main goal is to see …

This trial tests whether 3D-printed crowns work better than standard stainless-steel crowns for restoring damaged first permanent molars in children. The study will compare how well each crown holds up, its effect on gum health, and how satisfied children and parents are with the…

This trial compares standard knee replacement surgery to surgery using custom cutting blocks designed from each patient's anatomy. The goal is to see if these personalized tools lead to better knee function, less bleeding, shorter surgery time, and lower overall costs. About 95 p…

This study investigates whether high- or low-intensity inspiratory muscle training (IMT) better improves diaphragm function in patients who have been on mechanical ventilation for over 21 days. Using ultrasound, researchers will measure changes in diaphragm movement and thickness…

This study tests whether using hypochlorous acid—a mild disinfectant—during deep dental cleaning helps treat early-stage periodontitis (gum disease) better than cleaning with water alone. Researchers will measure gum healing, pocket depth, and inflammation markers in 44 adults wi…

This trial tests whether placing a synthetic bone graft material called beta-tricalcium phosphate into the gap around a dental implant helps it stay stable and promotes bone growth. The study involves 16 adults aged 20 to 50 who need an upper front tooth replaced immediately afte…

This pilot study tests whether electrical stimulation of the spinal cord can improve motor function and reduce spasticity in people with spinal cord injury. Participants receive epidural and dorsal root stimulation during 10 rehabilitation sessions. The study measures changes in …

This study compares two surgical techniques for treating gum recession: gingival unit grafting and conventional free gingival grafting. Researchers measure how well each graft matches the color of surrounding gum tissue and how much healthy gum tissue it adds over 18 months. The …

This phase 2 trial tests whether the drug abatacept can safely and effectively treat severe heart inflammation (myocarditis) caused by immune checkpoint inhibitors, a type of cancer immunotherapy. The study enrolls adults with any cancer who develop this rare but often fatal hear…

This trial tests whether using a low-power laser during a pulpotomy (removing infected pulp from a tooth) can improve healing and root formation in children aged 6 to 14 with painful, irreversible pulpitis in immature permanent molars. Participants receive either laser treatment …

This study tests whether adding a spermidine-based gel to standard deep-cleaning (MINST) improves gum pocket reduction in adults with periodontitis. Participants receive either the gel plus cleaning or cleaning alone, and gum health is tracked for 12 months. The goal is to see if…

This study tests a new, less invasive procedure called PIMSRA for children with obstructive hypertrophic cardiomyopathy, a condition where the heart muscle is too thick and blocks blood flow. The procedure uses a needle guided by ultrasound to deliver radiofrequency energy to the…

This study tests whether a newer, easier-to-use material called NeoPUTTY works as well as the standard MTA for saving permanent back teeth with severe nerve inflammation in children aged 9 to 14. Both materials are used to cover the remaining healthy nerve after removing the dise…

This study tests whether watching a video about brushing and flossing is as effective as a hands-on demonstration with a 3D model for people with gingivitis (early gum disease). Eighty adults with gingivitis will receive either a video link or a live demo, and their gum health wi…

This study tests two types of pit and fissure sealants (Fisseal and Prevent Seal) applied after treating teeth with one of two remineralizing agents (Biflourid or MI Paste). The goal is to see which combination best keeps the sealant in place and prevents cavities from forming or…

This study compares two surgical approaches for laparoscopic hysterectomy in women with benign or premalignant uterine conditions. One method uses a single incision through the belly button, while the other uses three to four small abdominal cuts. The goal is to see which techniq…

This trial compares three treatments for mature teeth with apical periodontitis (infection at the root tip): standard root canal treatment, regenerative endodontic treatment using a blood clot, and regenerative treatment with added bone-growth proteins. The study includes 30 heal…

This study compares two types of dental implant attachments used in full-arch fixed dentures (All-on-4) for people with no teeth in the lower jaw. The OT-Bridge system is tested against standard multiunit abutments to see which leads to higher patient satisfaction and fewer prost…

This trial compares two types of rotary files (Kedo-Nano Plus and Kedo-S Square) with traditional hand files for root canals in children's baby molars. About 60 healthy kids aged 5-8 with infected molars will receive a pulpectomy using one of the three tools. Researchers will che…

This study investigates whether a collagen hydrogel called H42 can help treat deep gum pockets caused by periodontitis or peri-implantitis. Researchers will measure changes in pocket depth, plaque, gum attachment, and bleeding over 90 days in adults aged 25 to 65 with 1 to 5 gum …

This study tests whether placing the final abutment once during dental implant surgery, without removing it during healing, reduces bone loss around the implant compared to standard repeated disconnections. Researchers will also measure patient satisfaction and analyze mouth bact…

This trial compares two surgical procedures for thumb arthritis at the base of the thumb. One is a newer technique called Mini TightRope suspensionplasty, which uses a small suture-button system to stabilize the joint. The other is the standard ligament reconstruction and tendon …

This trial compares two ways to replace missing teeth in people with jawbone loss: using short implants or standard implants with a bone regeneration procedure. Twenty participants are randomly assigned to one of the two treatments. The study measures bone level changes around th…

This study tests whether adding photodynamic therapy (PDT) to standard deep cleaning (scaling and root planing) improves gum disease treatment more than cleaning alone. The trial includes both smokers and non-smokers to see if the extra treatment helps smokers, who often have wor…

This study compares two types of dental implant connections — internal hexagon and conical — to see which one leads to better bone preservation, fewer complications, and healthier gums. Twenty adults needing two implant-supported crowns will receive one of each connection type, a…

This trial evaluates the safety and performance of three types of suture anchors (REGENESORB, Knotless REGENESORB, and Knotless PEEK) used to reattach soft tissue to bone in the shoulder or hip. About 300 people needing repair for labral tears, shoulder instability, or rotator cu…

This study tests whether a gel made from Centella asiatica (a herb) can improve standard treatment for gum disease. Adults with periodontitis receive either standard deep cleaning alone or cleaning plus the gel applied to the gums once a week for three months. Researchers measure…

This study tracks the safety and effectiveness of bosutinib (Bosulif) in people with chronic myelogenous leukemia (CML) who are either newly diagnosed or have not responded to or tolerated prior treatments. Researchers will monitor side effects and how well the drug controls the …

This trial tests three different ways of placing resin composite fillings in deep cavities to see which one causes the least irritation to the tooth's nerve (pulp). Adults with deep decay in their molars will receive one of the filling techniques, and researchers will measure inf…

This study compares the safety of baricitinib, an oral medication, against TNF inhibitors (injectable drugs like etanercept and adalimumab) in people with rheumatoid arthritis. The main focus is on the risk of venous thromboembolism (blood clots in veins). Participants include th…

This trial compares two approaches for a specific type of pelvic fracture (LC1) in people aged 60 and older. One group receives a minimally invasive surgery to place screws that stabilize the bone, while the other group gets pain management and physical therapy without surgery. T…

This study tests whether a three-month resistance training program using ankle weights can improve leg strength, balance, pain, and quality of life in people who have had knee replacement surgery for osteoarthritis. Twenty-four participants are randomly assigned to either the res…

This trial looks at whether antibiotics are needed after removing a tooth with a periapical abscess (an infection at the root tip). Half of the 176 adult participants receive amoxicillin for 5 days after extraction, while the other half get only pain relievers. A dentist checks t…

This study follows 208 adults who are scheduled for foot or ankle reconstruction surgery using the Io-Fix system, a device designed to stabilize bones during healing. The goal is to measure how well the bones fuse and how patients recover, using X-rays and health questionnaires. …

This study tests two types of fluoride varnish—one that hardens with a special light and a standard one—to see if they can reverse white spot lesions (early cavities) that often appear after braces are removed. About 38 teenagers who are finishing orthodontic treatment will recei…

This trial tests whether a collagen-based injection (Fibroquel) works as well as a standard hyaluronic acid injection (Synvisc) for knee osteoarthritis. About 32 adults with moderate knee OA will receive three weekly injections of one treatment. The study measures knee function a…

This study tests whether a new Sonicare power toothbrush head removes more dental plaque and reduces gum inflammation (gingivitis) than a standard manual toothbrush. About 100 adults with gingivitis will brush twice daily with either the power or manual brush for six weeks. Resea…

This phase 2 trial tests whether giving ruxolitinib (Jakafi) before, during, and after a stem cell transplant can improve outcomes for people with myelofibrosis. The study includes patients with intermediate-2 or high-risk disease, or intermediate-1 with additional risk factors. …

This study uses machine learning to identify biomechanical risk factors for common running injuries like shin splints, runner's knee, and Achilles tendon pain in recreational runners. Participants undergo motion capture and muscle activity analysis while running, then are followe…

This study tests whether low-load arm exercises combined with inflatable cuffs that briefly restrict blood flow can improve muscle size and small blood vessel health in older adults. Participants aged 50 and older are randomly assigned to exercise with the cuffs, exercise without…

This study tests whether non-surgical gum treatment (deep cleaning) can improve oral health and quality of life in adults with hemophilia A or B. Researchers compare changes in gum health and daily comfort (using a questionnaire) between hemophilia patients and healthy individual…

This study compares a new, less invasive gum surgery (NIPSA) alone versus the same surgery plus a bone graft and platelet-rich fibrin to repair deep bone defects caused by advanced periodontitis. The trial enrolls adults with stage III periodontitis who have at least one deep gum…

This trial tests whether placing a hyaluronic acid gel into the empty socket after lower wisdom tooth removal can prevent dry socket—a painful condition where the blood clot fails to form or is lost. The study includes 64 healthy adults who need a lower wisdom tooth extracted. Re…

This study tests whether adding platelet-rich plasma (PRP) — a concentrated solution made from a patient's own blood — to standard rotator cuff repair surgery improves healing. About 51 adults with confirmed rotator cuff tears who have not improved with physical therapy will rece…

This trial investigates whether a single dose of antibiotics before hip replacement surgery prevents joint infections as effectively as multiple doses. The study involves about 20,000 adults with osteoarthritis undergoing hip replacement at hospitals across Denmark. Researchers w…

This trial investigates whether tranexamic acid, a drug that reduces bleeding, improves visual clarity during arthroscopic rotator cuff repair. Patients with full-thickness rotator cuff tears receive the drug either through an IV or directly into the joint, and surgeons rate how …

This trial tests whether specially framed text messages can improve oral health and quality of life in refugees living in Alexandria, Egypt. Participants receive either gain-framed messages (highlighting benefits of good oral care), loss-framed messages (highlighting risks of poo…

This study tests whether watching a video of someone walking, projected below a mirror, can help people with incomplete spinal cord injury improve their walking, strength, and sensation. The idea is that mirror neurons in the brain may be activated by seeing the movement, promoti…

This trial investigates whether a concentrated growth factor (CGF) preparation, made from a patient's own blood, can reduce pain and improve function in people with knee osteoarthritis. Participants receive three weekly injections of either CGF or standard platelet-rich plasma (P…

This study investigates whether a passive stretching program can reduce muscle and tendon stiffness in people with type 2 diabetes. Diabetes can cause muscles and tendons to become stiffer, making walking harder and increasing energy use. The trial compares stiffness in people wi…

This phase 2 trial is testing whether combining two drugs, ponatinib and 5-azacitidine, can improve survival in people with advanced chronic myeloid leukemia (CML). The study includes adults whose CML has progressed to an accelerated phase or a more aggressive blast crisis. Parti…

This trial investigates whether taking a collagen supplement alongside standard non-surgical gum treatment (deep cleaning) can improve outcomes for people with advanced periodontitis (stage 3-4). Half of the 52 participants will receive the supplement, while the other half gets a…

This early-phase study tests whether a combination of two medications (neostigmine and glycopyrrolate) can be delivered through the skin using a mild electric current to help people with spinal cord injury have a bowel movement. Participants first receive the medication intraveno…

This trial investigates whether nerve transfer surgery can restore hand function in people with cervical spinal cord injury. Participants undergo a personalized nerve transfer procedure to reconnect nerves and improve arm and hand strength. Researchers track changes in motor stre…

This study tests whether adjusting the daily dose of the leukemia drug dasatinib based on a patient's blood levels can improve safety and effectiveness. Adults newly diagnosed with chronic phase chronic myeloid leukemia (CML) will receive either standard dosing or a dose tailored…

This phase 2 trial tests whether adding pioglitazone (a diabetes drug) to the standard leukemia medication imatinib can eliminate remaining cancer cells in people with chronic-phase chronic myeloid leukemia (CML). Participants must have been on imatinib for at least two years and…

This trial tests whether adding the targeted drug ponatinib to standard chemotherapy (cytarabine) can help prevent relapse in adults with a specific, high-risk genetic form of acute myeloid leukemia (FLT3-ITD AML) who are already in first remission. The study includes two age gro…

This pilot trial tests whether a supervised progressive strength and balance exercise program can reduce falls in postmenopausal women aged 60 to 80 with osteoporosis. Participants are randomly assigned to either the supervised program or a standard home-based exercise routine an…

This trial tests whether a single injection of stem cells, called Chondrochymal®, can reduce pain and improve function in people with knee osteoarthritis. Participants are adults aged 40 to 80 with moderate to severe knee arthritis who are not ready for or cannot have knee surger…

This trial investigates whether adjusting the dose of imatinib (Gleevec) based on the drug's level in the blood can improve outcomes for people newly diagnosed with chronic phase chronic myeloid leukemia (CML). Participants whose imatinib blood level is low after 28 days are rand…

This trial tests whether taking probiotics by mouth, along with standard root canal medications, can reduce pain and improve healing in people with chronic tooth infections. Participants will receive either a probiotic capsule or a placebo for 21 days, combined with one of three …

This study tests whether artificial intelligence (AI) can help emergency room doctors find broken bones, dislocations, and other bone problems more quickly and accurately. About 4,800 patients with arm or leg injuries will have their X-rays reviewed either with or without AI assi…

This trial tests whether an ultra-low-dose CT scan, using a new image reconstruction algorithm, can produce images good enough for diagnosing lung, abdominal-pelvic, and bone lesions, compared to a standard-dose CT scan. About 116 adults will receive both scans as part of their u…

This study tests whether a standardized way of taking spine X-rays gives consistent results. 45 people with back or leg pain will have two sets of X-rays to see if the measurements match. The goal is to improve how doctors diagnose spinal instability.

This study investigates whether advanced heart imaging and blood tests can detect early signs of heart damage in adults who received anthracycline chemotherapy as children. Anthracyclines are effective cancer treatments but can increase the risk of cardiomyopathy years later. Cur…

This study tests whether a special light-based scanner, called DIAGNOcam, can better detect early cavities between teeth when used with a dye. Researchers will compare this method to standard X-rays and a visual-tactile exam. The goal is to see if the dye improves the ability to …

This study explores whether wearable motion sensors can improve screening for fall risk in people with chronic conditions like osteoarthritis, Parkinson's disease, COPD, and obesity. Participants will perform two standard walking tests while wearing small sensors that measure mov…

This completed Phase 3 study tested whether a radioactive tracer called [18F]Florbetaben, used in PET scans, can accurately diagnose cardiac AL amyloidosis—a condition where abnormal proteins build up in the heart. 244 adults with suspected cardiac amyloidosis received a single P…

This trial evaluates a new high-sensitivity blood test (Mindray hs-cTnI) for diagnosing heart attacks in people arriving at the emergency room with symptoms like chest pain. Researchers will compare the test's accuracy against an existing approved test, using blood samples taken …

This study investigates whether three common lab tests — blood levels of ESR and CRP, plus a leukocyte esterase dipstick test on joint fluid — can reliably diagnose chronic infection in people who have had a total joint replacement. The researchers will compare the test results a…

This study explores whether a cardiac MRI can safely and effectively gather the same heart pressure and flow measurements normally obtained through right heart catheterization, a more invasive procedure. Researchers will attempt to perform the catheterization inside the MRI machi…

This study tests whether a fluorescent dye called tozuleristide, given before surgery, can make brain tumor tissue glow under a special imaging system. Surgeons can then see and remove more of the tumor while sparing healthy brain. The trial enrolls adults with certain types of b…

This study develops and tests an artificial intelligence model that analyzes standard dental photographs to detect gum recession, classify its severity, and suggest treatment options. Researchers use images from adults with visible gum recession to train the AI and compare its ac…

This study tests an artificial intelligence system that measures the width of keratinized gingiva (a type of gum tissue) from smartphone photos. Researchers will compare the AI's measurements to those made by dental experts to see how accurate the tool is. The goal is to make gum…

This study evaluates how accurately the Root ZX3 electronic apex locator measures the working length of root canals in single-rooted teeth that need to be extracted. Researchers compare the device's measurements with microscopic measurements taken after extraction, which serve as…

This study tests whether a non-invasive imaging tool called swept-source optical coherence tomography (SS-OCT) can detect early signs of tooth erosion caused by acidic drinks. Twenty-two healthy adults swished orange juice repeatedly over three days, and their teeth were scanned …

This trial tests whether giving azithromycin—a common antibiotic—twice a year to young children in Niger can reduce deaths. It compares giving the drug to all children aged 1-59 months versus only to infants 1-11 months, who are at highest risk. The study also checks how these ap…

This study tests whether a new high-intensity exercise program is feasible and can improve dynamic balance and physical activity in adolescents with cerebral palsy or spina bifida. Participants will perform a series of exercises twice a week, with researchers measuring walking sp…

This trial tests whether online educational modules or live webinars, completed before hip replacement surgery, can reduce anxiety and improve outcomes like pain, function, and quality of life. It involves adults aged 50 and older with advanced hip osteoarthritis who are schedule…

This study tests whether a toothpaste designed for sensitive teeth can also improve oral hygiene and gum health in people with dentine hypersensitivity. Participants will use the toothpaste over time, and researchers will measure changes in tooth sensitivity, plaque buildup, and …

This study tests whether a cream made with L-menthol and balsam copaiba oil can reduce symptoms of arthritis, joint pain, and muscle pain. Adults aged 20 to 65 with mild-to-moderate joint discomfort apply the cream or a placebo to affected areas three times daily for seven days. …

This study compares task-oriented occupational therapy to standard rehab for people recovering from rotator cuff surgery. Thirty participants will be randomly assigned to one of two groups, attending 40-minute sessions twice a week for 10 weeks. The goal is to see if focusing on …

This trial tests whether listening to preferred music or squeezing a stress ball during cataract surgery can reduce patients' pain and anxiety. About 240 adults having their first cataract surgery will be assigned to one of these two simple, drug-free techniques or to standard ca…

This small early-phase trial tests whether a single oral dose of a hemp-derived CBD/CBD-A extract can reduce neuropathic pain and change brain activity in people with spinal cord injury. Six participants with moderate to severe nerve pain for at least three months will receive ei…

This study looks at whether aggressive weight loss using semaglutide can improve symptoms in people with a specific type of heart failure linked to obesity. About 81 participants with a BMI of 30 or higher and heart failure with preserved ejection fraction will receive either sem…

This trial compares two ultrasound-guided pain-relief techniques for children aged 1 to 12 undergoing surgery on the front or side of the thigh. One group receives a fascia iliaca nerve block, while the other gets caudal analgesia, both given after general anesthesia. The goal is…

This study tests whether combining electroacupuncture (using mild electric pulses on needles) with ear acupressure (using small seeds on ear points) can reduce pain and improve function in people with chronic low back pain. 76 adults aged 40-70 with pain lasting at least 12 weeks…

This study asks whether the physical and social environment where shoulder treatment happens can influence pain, function, and satisfaction. Adults with rotator cuff-related shoulder pain will follow the same exercise program but in different therapeutic settings. Researchers wil…

This trial tests whether wearing virtual reality goggles that show relaxing nature scenes can reduce pain, anxiety, and sleep problems in people recovering from total knee replacement surgery. Half of the participants will receive standard care plus the virtual reality sessions, …

This trial tests whether children and teenagers who have just had surgery for idiopathic scoliosis can safely stand up within 6 hours after the operation. Participants will be helped by a physiotherapist to stand in an upright position, as part of an enhanced recovery program. Th…

This study tests whether a low-carbohydrate diet (under 40 grams of carbs per day) can reduce pain and improve quality of life in women aged 65-75 with knee osteoarthritis. It specifically looks at whether the diet's effects differ between African-American and non-Hispanic white …

This trial tests whether different kinesio taping methods can reduce pain and stiffness in people with myofascial pain syndrome, a condition where sensitive spots in muscles cause pain. Participants will be divided into groups receiving either a muscle-inhibition tape, a special …

This trial tests whether giving trigger point injections—small amounts of numbing medication into tender neck muscles—shortly after anterior cervical surgery can reduce pain and the need for opioid painkillers. Patients undergoing elective anterior neck surgery are randomly assig…

This study compares two non-invasive treatments—high-power laser and pulsed electromagnetic therapy—for reducing pain and improving nerve function in people with lumbar radiculopathy (sciatica from a herniated disc). Sixty participants aged 55-68 will receive one of the therapies…

This study tests an electronic program that combines mindfulness and music therapy for people undergoing stem cell transplants for blood cancers. The goal is to see if it improves quality of life and reduces symptoms like pain. About 60 adults will participate, and the program in…

This study compares two types of nerve blocks for pain after hip replacement surgery. Sixty adults will receive either a sacral erector spinae plane block or a fascia iliaca compartment block, both using a numbing medicine through a small tube. The goal is to see which method red…

This trial tests whether using an iPhone with interactive rehabilitation software (HappyGoGo) for daily home exercise can improve pain, range of motion, and quality of life in people with frozen shoulder. Thirty participants are randomly assigned to either standard rehab plus the…

This trial tests whether virtual reality exercise games or electrical muscle stimulation can reduce shoulder pain and improve movement in people with chronic kidney disease who are on dialysis. Participants will receive one of the two therapies several times a week for eight week…

This trial tests whether adding music therapy to standard rehabilitation helps people recover better after serious neurological injuries like stroke, brain injury, or spinal cord damage. About 75 participants aged 16-80 will be randomly assigned to receive either music therapy or…

This study tests whether a new physiotherapist-led primary care model can improve function and quality of life for adults with hip or knee pain. About 728 participants in Canada will be assigned to either the new model or usual care. The goal is to see if this approach reduces pa…

This study tested two techniques for washing out the jaw joint (arthrocentesis) in 30 adults with TMJ disorders. One method used a single needle, the other a catheter. Researchers measured pain and how wide patients could open their mouths. The goal was to see which approach prov…

This study looked at whether the drug Acthar can reduce inflammation and improve symptoms during a rheumatoid arthritis (RA) flare. Forty adults with RA who were having a flare took part. Researchers used ultrasound and disease activity scores to measure changes after treatment.

This study tests whether a wearable exoskeleton—a supportive device worn around the torso—can reduce physical effort and pain for nursing home staff who regularly lift, turn, and bathe residents in bed. Over 11 weeks, 35 care workers across five French nursing homes will wear the…

This study looks at whether adding deep friction massage to a standard exercise program helps people with bicipital tendinitis (a painful shoulder condition). Researchers will measure pain, movement ability, fear of movement, and quality of life in 42 adults aged 20-55. The goal …

This study looks at whether adding cognitive behavioral therapy (CBT) and exercise to knee replacement surgery helps reduce pain and improve function. About 282 adults with knee osteoarthritis are randomly assigned to one of three groups: a non-surgical program with CBT and exerc…

This study looks at how two common treatments for myofascial jaw pain—a mouth splint and lidocaine injections—affect the muscles of the jaw and neck. Researchers use ultrasound to see changes in muscle structure, like how well the muscle fibers reflect sound waves. The goal is to…

This trial tests a 12-week smartphone-based program called PACT, which combines acceptance and commitment training with positive parenting advice, for parents of children with special health care needs. The goal is to see if it can improve parents' mental well-being, psychologica…

This trial tests whether adding virtual reality (VR) exercises to a standard rehabilitation program can improve pain, balance, and quality of life in people with symptomatic knee osteoarthritis. Adults aged 40-85 with chronic knee pain will either receive conventional rehab alone…

This trial tests whether adding shoulder and neck mobilization to standard physical therapy (hot packs, TENS, ultrasound, and exercises) can better reduce pain and improve function in people with subacromial impingement syndrome. Adults diagnosed with this shoulder condition will…

This study looks at how a 3-month program of exercise and education affects pain and quality of life in people with hand osteoarthritis. Researchers will analyze data from 2,000 participants in the Swedish Osteoarthritis Registry. The goal is to see if this first-line treatment h…

This trial tests whether low-level laser therapy or a hyaluronic acid gel can improve healing after free gingival graft surgery, a procedure to treat receding gums. Adults with insufficient gum tissue in the lower front teeth will receive surgery alone, surgery plus laser, or sur…

This trial tests whether adding Gua Sha—a traditional scraping therapy—to standard care can improve pain and function in people with lumbar disc herniation. The therapy is applied to the bladder meridian during the 'Shen period' (3–5 p.m.), based on traditional Chinese medicine's…

This study tests whether a combination of special stretches and movement retraining can reduce shoulder pain and improve motion in fast bowlers with a condition called GIRD (limited internal rotation). 42 male cricketers aged 18-45 will be split into two groups: one gets the new …

This study tests whether two types of percutaneous electrolysis (simple or multifilar) or laser therapy better relieve pain and improve shoulder movement in people with supraspinatus tendinopathy, a common cause of shoulder pain. Participants receive one treatment session and are…

This trial tests whether giving patients an educational booklet before total knee replacement surgery improves their knowledge and beliefs about the procedure. Adults aged 55 to 75 scheduled for knee replacement will receive the booklet or standard care. Researchers will measure …

This trial tests whether adding breathing exercises to standard physiotherapy improves lung function, pain, and quality of life in people with thoracic discopathy, a condition affecting the upper spine. Forty participants will be randomly assigned to receive either 15 sessions of…

This study looked at how well paracetamol alone or combined with different NSAIDs (ibuprofen, mefenamic acid, or diclofenac) controls pain after root canal treatment. 185 adults with severe tooth pain took part. The goal was to see if combining drugs works better than paracetamol…

This study tests whether a gamified physical therapy software, called Yoomi, can help older hospital patients exercise safely in their beds. The goal is to see if this fun, interactive approach can preserve muscle strength and function during a hospital stay, reducing the need fo…

This study tested two physical therapy techniques—myofascial release and positional release—in 30 young adults with neck pain from a condition called unilateral trapezitis. Both treatments reduced pain, improved neck movement, and eased disability when added to standard exercises…

This trial tests whether practicing tai chi can increase overall physical activity in people with spondyloarthritis, a type of inflammatory arthritis. Participants will either take tai chi sessions for two or four months or receive no tai chi (control group). The study measures c…

This study tested two hands-on treatments—tissue flossing (wrapping the calf with a band) and myofascial release (deep massage)—to see which better helps young adults with flat feet. 44 people aged 18-25 with flexible flat feet and calf pain took part. The goal was to improve bal…

This study tests whether MRI scans can predict how much people with jaw joint problems improve after a single injection of hyaluronic acid combined with platelet-rich plasma (PRP) made from their own blood. Adults aged 18–45 with TMJ internal derangement who haven't improved with…

This trial compares two ways of using radiofrequency energy to block knee nerves in people with osteoarthritis-related knee pain that hasn't improved with other treatments. One method uses a single probe (monopolar), the other uses two probes (bipolar). The study will measure pai…

This study tests whether a water flosser can improve oral health in adults with plaque-induced gingivitis. Sixty-four healthy adults will use the device twice daily after brushing. Researchers will measure changes in plaque and gum inflammation over time.

This study tests whether an 8-week Pilates program can reduce pain and improve jaw function in women with myogenic temporomandibular disorders (TMD), a common cause of jaw pain and stiffness. Participants will be randomly assigned to either a control group receiving standard educ…

This trial tests whether two myofascial release techniques—using a Graston device or a foam roller—can acutely improve jumping, balance, flexibility, and proprioception in amateur football players. Sixty licensed players aged 18-35 will receive one of the two treatments, and thei…

This trial tests whether a 12-week ketogenic diet program, delivered entirely online, is practical and acceptable for adults with Long COVID who also have ME/CFS and dysautonomia. Participants follow a low-carb, high-fat diet with vitamin B1 and electrolyte support, plus weekly v…

This study tests whether combining two types of hand exercises—Mulligan's mobilization and tendon gliding—can improve hand function in smartphone users with De Quervain's tenosynovitis, a painful thumb condition. About 44 participants will be randomly assigned to either the exerc…

This study looks at two different hands-on therapy methods (Mulligan and PNF) added to standard physical therapy for people with partial rotator cuff tears. 45 adults aged 30-70 will be split into three groups to see which approach best reduces pain, improves shoulder movement, a…

This trial tests whether a wearable suit called EXOPULSE Mollii, which sends gentle electrical pulses to muscles, can help children with cerebral palsy. The study focuses on kids aged 5 to 12 who have spasticity and some walking ability. Researchers will measure changes in balanc…

This trial tests whether cooling and ablating genicular nerves before total knee replacement surgery can reduce post-operative pain and improve recovery. Participants will receive either unilateral or bilateral genicular nerve cooled radiofrequency ablation, followed by epidural …

This trial asks whether a numbing injection directly into the knee works as well as a continuous nerve block for controlling pain after knee replacement surgery. Adults aged 18 to 90 with knee arthritis scheduled for a first knee replacement are randomly assigned to receive eithe…

This trial tests whether adding transcutaneous electrical nerve stimulation (TENS) to standard care—education, medication, and exercises—provides extra pain relief and better jaw function for people with temporomandibular disorders (TMD). About 48 adults with TMD will receive eit…

This pilot study tests whether a technique called conditioning with open-label placebo (COLP) can help patients with spinal cord injuries, polytrauma, or burns reduce their opioid painkiller doses without losing pain relief. Participants receive a sugar pill and an essential oil …

This study tests whether a cream made with cetylated fatty acids can ease knee pain and improve function in adults with osteoarthritis. Participants apply the cream or a placebo to the affected knee twice daily for 30 days. The trial measures changes in pain during walking, physi…

This trial investigates whether placing a retraction cord—a thin thread that pushes the gum aside—during a tooth restoration affects gum health. Adults with non-carious cervical lesions (tooth damage near the gumline not caused by decay) will receive composite restorations either…

This study tests a new way to use deep brain stimulation for people with severe, treatment-resistant chronic pain from stroke, spinal cord injury, or phantom limb pain. Instead of constant stimulation, the device delivers electrical pulses only when the brain senses high pain sig…

This study tests a behavioral program called Moving Well to see if it can reduce anxiety and depression in people waiting for knee replacement surgery. About 79 participants will either get the coaching program or a general wellness program. The goal is to improve emotional well-…

This study tests whether learning Argentine tango can increase overall physical activity in people with chronic inflammatory arthritis, such as rheumatoid arthritis or spondyloarthritis. Participants will take tango sessions that focus on body awareness, movement, and connection …

This early-stage study looked at whether giving two standard chemotherapy drugs (cytarabine and daunorubicin) in a different way could be safer for the heart in adults newly diagnosed with acute myeloid leukemia (AML). Researchers used heart MRI scans to monitor for damage. The g…

This trial tests whether adding a self-management education program to a three-week spa treatment can increase physical activity levels in people with knee osteoarthritis. The program includes educational workshops and a written booklet, and the study will measure physical activi…

This study looks at whether virtual reality (VR) therapy or a simple deep rest relaxation technique can help older adults feel less stressed and recover better after hip or knee replacement surgery. About 90 people aged 60 and older who recently had surgery will try one of these …

This trial tests whether two experimental mouthwashes can relieve dentinal hypersensitivity—sharp pain from hot, cold, or air on teeth. About 118 adults with sensitive teeth will use one of the mouthwashes or a placebo, either once or twice daily, for up to 8 weeks. Researchers w…

This trial compares a toothpaste with stannous fluoride against a popular potassium-based desensitizing toothpaste and a regular fluoride toothpaste. About 116 adults with sensitive teeth will brush twice daily for a week. The goal is to see if the stannous fluoride formula reduc…

This trial tests three ultrasound-guided treatments for myofascial pain syndrome in the upper neck muscle: dry needling, lidocaine injection, and oxygen-ozone injection. About 76 adults with neck pain lasting at least three months will receive one of these treatments weekly for t…

This trial tests whether different types of ultrasound therapy can ease pain and stiffness in people with knee osteoarthritis. Adults aged 45 to 65 with mild-to-moderate knee arthritis will receive ultrasound treatment, sometimes with a metformin gel applied to the skin. The stud…

This trial tests whether optimizing protein intake—through dietary counseling and whey protein supplements—can reduce household work limitations and overall disability in women with rheumatoid arthritis. Participants will aim for 1.0 gram of protein per kilogram of body weight da…

This trial tests whether a wide-awake local anesthesia technique called WALANT can match the results of general anesthesia for shoulder manipulation in people with frozen shoulder. Adults who have had symptoms for at least six months without improvement are randomly assigned to o…

This trial tests a small implantable device, the Calypso Knee System, designed to act as a shock absorber for people with knee osteoarthritis pain on the inner side of the knee. The study includes adults aged 25 to 65 who have not gotten relief from at least six months of non-sur…

This trial compares Botox injections with ibuprofen pills to see which better eases jaw muscle pain and improves quality of life in people with sleep bruxism (teeth grinding). Forty adults with jaw pain are randomly assigned to receive either Botox injections into the masseter an…

This trial asks whether photobiomodulation — a type of low-level laser therapy — can lessen pain and swelling after endodontic (root-end) surgery. Thirty-four adults needing surgery on an upper tooth will be randomly assigned to receive either the laser treatment or a sham proced…

This trial tests whether adding trunk (core) stabilization exercises to a standard foot exercise program can improve dynamic balance and foot function in young adults with pronated (flat) feet. Thirty participants aged 18–25 with bilateral flat feet will be randomly assigned to e…

This trial tests whether shining red and infrared LED light on the jaw and neck muscles can reduce pain and improve movement in people with temporomandibular joint (TMJ) disorders. About 32 adults with TMJ pain will receive either real LED therapy or a placebo treatment over six …

This trial tests whether stem cells from children's shed baby teeth can replace the standard hip bone graft for repairing a cleft in the upper jaw. Twenty children aged 7 to 12 with cleft lip and palate will receive either the stem cell graft or a traditional bone graft from thei…

This study tests whether an implantable device called the Calypso Knee System can relieve pain and improve function in people with knee osteoarthritis that has not responded to at least six months of non-operative treatment. The device acts as a shock absorber to offload the inne…

This trial tests whether adding clamshell exercises — a hip-strengthening move — to standard physical therapy can better reduce pain and improve knee function in people with patellofemoral pain syndrome (pain around the kneecap). Forty adults aged 18 to 45 with this common knee c…

This trial investigates whether eccentric isokinetic exercise — a type of controlled, lengthening muscle contraction performed on a special machine — can reduce pain and improve shoulder function in people with rotator cuff tendinopathy. Fifty adults aged 20 to 50 with confirmed …

This trial investigates whether combining Tui-na, a traditional Chinese massage technique, with an oral herbal formula called Du-Huo-Ji-Sheng-Tang can reduce pain and improve function in people with knee osteoarthritis. Participants aged 50 and older with knee osteoarthritis will…

This trial tests whether a long-acting anesthetic called liposomal bupivacaine can reduce pain after gum surgery better than the standard medium-acting anesthetic. Adults scheduled for gum surgery on 2 to 5 teeth will receive one of the two anesthetics injected near the surgical …

This trial tests whether adding a small dose of hydromorphone to a standard numbing medicine (ropivacaine) improves pain control after total knee replacement. About 90 adults undergoing knee surgery will receive either the combination or the numbing medicine alone via a nerve blo…

This trial investigates whether adding graded motor imagery (GMI) therapy—a sequence of left/right discrimination, mental imagery, and mirror therapy—to standard physiotherapy can improve pain, movement, and function in people with shoulder impingement syndrome. Thirty adults age…

This trial tests whether intermittent or continuous blood flow restriction (BFR) training works better for easing pain, improving strength, and boosting function in women aged 40–49 with grade II knee osteoarthritis. Participants will perform low-load exercises while a cuff aroun…

This phase 2 trial tests whether giving the sedative dexmedetomidine during pituitary tumor surgery can dampen the body's stress response and improve early recovery. About 64 adults with non-functioning pituitary adenomas undergoing endoscopic transsphenoidal surgery will be rand…

This trial compares two irrigation solutions used during regenerative endodontic treatment for immature permanent teeth with infection. Forty children aged 9 to 16 will receive either octenidine or EDTA as a rinse, and their pain levels will be tracked for a week. The goal is to …

This trial tests whether warming up dental filling materials before placement can reduce inflammation inside the tooth and lessen pain after treatment. Thirty adults with deep cavities will receive fillings at different temperatures — one group gets a special flowable composite p…

This study compares Mobithron, a supplement containing hyaluronic acid, collagen, and Boswellia, to standard glucosamine for easing pain and improving function in people with knee osteoarthritis. Adults aged 50 to 75 with knee osteoarthritis take either Mobithron or glucosamine d…

This trial tests whether an all-in-one dental isolation system called Isolite is more comfortable for children than the traditional rubber dam during cavity treatment. Sixty-six kids aged 8 to 12 will try both methods in random order, and researchers will measure pain, comfort, a…

This study asks whether the phase of the menstrual cycle influences pain and anxiety during a deep dental cleaning in premenopausal women with moderate gum disease. Researchers will compare pain scores and anxiety levels when treatment is done just before or just after menstruati…

This trial tests two non-surgical injectable treatments for a gummy smile, where too much gum shows when smiling. Twenty adults with a gummy smile of 3 mm or more received either botulinum toxin (Botox) or a hyaluronic acid filler. The study measures how much the gum exposure is …

This study tests whether adding individual and family education to standard scoliosis-specific exercises can reduce stress, improve body image, and increase quality of life in adolescents with idiopathic scoliosis. About 42 teens aged 10–18 will be randomly assigned to receive ei…

This trial investigates whether custom foot orthoses (shoe inserts) with or without special wedges can reduce pain and improve foot function in people with plantar heel pain (plantar fasciitis). Participants are randomly assigned to one of three orthosis types and are monitored d…

This trial compares two ways of giving the anti-inflammatory drug piroxicam to control pain after root canal treatment: a standard oral pill versus an injection into the ligament around the tooth. Adults with a toothache caused by irreversible pulpitis will receive one of the two…

This study tests whether adding instrument-assisted soft tissue mobilization (IASTM) to standard therapeutic exercises can better reduce pain, improve knee range of motion, and boost daily function in people with knee osteoarthritis. Fifty adults aged 40 to 60 with knee OA will r…

This trial tests two ways to deliver a steroid injection for adhesive capsulitis, or frozen shoulder — a condition that causes pain and stiffness. One method injects into the shoulder joint, the other into the tissue around it, both guided by ultrasound. Researchers want to see w…

This study tests whether using cooled liquid to clean the inside of a tooth during root canal treatment can reduce pain afterward. It includes adults with certain tooth conditions who need a root canal. The approach involves comparing cooled versus room-temperature irrigation to …

This trial tests whether adding dry needling or kinesio taping to standard strength training can improve pain, mobility, and quality of life in people with knee osteoarthritis. Fifty participants aged 45–65 with moderate-to-severe pain will be randomly assigned to one of three gr…

This study compares two hands-on therapy techniques—joint distraction and passive end-range overpressure—for people with knee osteoarthritis. Participants, aged 40 to 60 with moderate knee pain, receive one of the two treatments over four weeks. The goal is to see which approach …

This trial investigates whether histotripsy, a focused ultrasound technique, can reduce pain in people with plantar fasciitis that has not responded to standard treatments like shock waves, orthotics, or steroid injections. Participants receive two ultrasound sessions and report …

This trial compares two ultrasound-guided nerve blocks—interscalene and supraclavicular—for controlling pain after outpatient arthroscopic rotator cuff repair. About 108 adults undergoing surgery will receive one of the two blocks, and researchers will measure how much opioid pai…

This study looks at how corticosteroid injections into the knee joint affect pain, movement, and daily function in children and teens with juvenile idiopathic arthritis (JIA). Researchers measure changes before the injection, two weeks after, and two months after. The goal is to …

This trial compares two minimally invasive treatments—Antivet and Opalustre—for improving the appearance of mild enamel fluorosis, a condition that causes tooth discoloration. Adults aged 20 to 35 with mild fluorosis on their front teeth are randomly assigned to receive one of th…

This study investigates whether adding osteopathic visceral manipulation (OVM) — gentle mobilization of the liver and diaphragm — to a standard physical therapy program can reduce pain, improve range of motion, and lessen disability in people with right shoulder adhesive capsulit…

This trial tests whether a corticosteroid injection given before root canal treatment can reduce pain and inflammation afterward. One hundred adults with symptomatic pulpitis (tooth nerve inflammation) are randomly assigned to receive either standard root canal treatment alone or…

Dental fluorosis can leave chalky white spots on front teeth, affecting appearance even when the enamel is intact. This trial compares two gentle treatments—resin infiltration and enamel microabrasion followed by a calcium-phosphate paste—for masking those spots. Researchers meas…

This study looks at how well people stick to two different home-based programs after total knee replacement surgery: standard physiotherapy exercises and a program that adds music-assisted progressive muscle relaxation. Researchers want to see if adding relaxation improves adhere…

This trial investigates whether a manual therapy called the Jones Technique, a combination of ultrasound and TENS, or both together can reduce neck pain caused by muscle knots in the upper back. The study includes women aged 18 to 40 with active trigger points and neck pain lasti…

This study tests whether injecting dextrose (sugar water) into painful muscle knots, called myofascial trigger points, can reduce pain. Adults with trigger point pain in the upper back and neck are randomly assigned to receive an injection of normal saline, 5% dextrose, or 15% de…

This trial compares two hands-on treatments for chronic tennis elbow (lateral epicondylitis): manual cross friction massage and instrument-assisted soft tissue mobilization (IASTM). Adults aged 18 to 60 with elbow pain lasting at least six months will receive one of the two techn…

This study compares two common therapies—dry needling and cupping—for people with myofascial pain syndrome, a condition causing persistent muscle knots and pain. Participants receive either dry needling or cupping, and researchers measure changes in pain intensity, number of trig…

This study tested whether an injection of platelet-rich plasma (PRP) made from a patient's own blood can reduce pain and clicking in the jaw joint (TMJ) and improve mouth opening. Thirty adults with a slipped jaw disc were randomly assigned to receive PRP, a steroid with anesthet…

This study compares two injection treatments for frozen shoulder (adhesive capsulitis). One group receives a standard steroid injection, while the other gets the same steroid plus extra saline to gently stretch the shoulder capsule. Researchers will measure pain, range of motion,…

This study tests whether taking ibuprofen before a root canal can improve the effectiveness of local anesthesia in people with severe tooth inflammation (irreversible pulpitis). Participants will receive either ibuprofen or a placebo before the procedure, and pain levels will be …

This study compares two treatments for frozen shoulder (adhesive capsulitis): applying an anti-inflammatory gel through ultrasound (phonophoresis) versus a muscle relaxation exercise technique (post-isometric facilitation). About 45 adults aged 30–40 with the second stage of froz…

This study compares acute pain after partial knee replacement (unicompartmental knee arthroplasty) between patients who go home the same day and those who stay in the hospital. Researchers track pain scores and knee function in 244 adults aged 50 to 75. The goal is to see whether…

This trial investigates whether adding therapeutic ultrasound to a standard exercise program helps people with shoulder impingement syndrome feel less pain and move better. About 120 adults aged 30 to 75 with shoulder pain will receive either active ultrasound or a placebo ultras…

This study tests whether a mindfulness-based psychoeducation program can help people hospitalized with lumbar disc herniation. The program includes eight sessions covering mindfulness, pain education, and emotional awareness. Researchers will measure changes in mindfulness, autom…

This study tests whether an ultrasound-guided injection of local anesthetic into the space behind the knee (called the IPACK block) can reduce pain and improve function in people with advanced knee osteoarthritis. Researchers will measure pain, disability, and quality of life at …

This study compares two common treatments for De Quervain's tenosynovitis, a painful wrist condition: a single steroid injection versus a minor surgical release. Researchers will track pain levels in 100 adults over six months to see which approach offers better relief. The goal …

This trial investigates whether acupuncture can reduce pain and improve function in people with spinal cord injury. Participants receive either acupuncture with electrical stimulation plus ear acupuncture, or standard care alone, for eight weeks. The study measures pain levels, q…

This study compares two ultrasound-guided injection treatments for adhesive capsulitis, also known as frozen shoulder. One group receives a steroid and numbing medicine injected directly into the shoulder joint, while the other group gets the same medicine injected near the supra…

This clinical trial tests a gel called ABIO3419, injected into the knee joint, to see if it safely reduces pain and improves function in people with knee osteoarthritis. The study compares ABIO3419 to another treatment and measures pain relief over three months. Participants are …

This study investigates whether adding dance-based exercises to standard scoliosis therapy improves physical fitness, body image, and quality of life in adolescents with mild scoliosis. Twenty-four teens aged 10–18 with a spinal curve between 10 and 30 degrees will be randomly as…

This study looked at Smith-Lemli-Opitz syndrome (SLOS), a rare genetic condition that affects cholesterol production and causes birth defects and intellectual disabilities. Researchers enrolled 130 patients and their mothers to learn more about the disease's progression, genetic …

This study looked at whether teaching mothers about their family health history can help them encourage healthier eating and exercise in their families. About 310 adults with at least one child took part. Researchers gave them a Family Health Package with personalized risk info a…

This study looks at how often women develop intrauterine adhesions (scar tissue inside the uterus) after having fibroids removed through laparoscopic or open surgery. Researchers will check for adhesions using a small camera inserted into the uterus three months after surgery. Th…

This study looked at nearly 1,400 people with rare conditions like PPNAD, Carney Complex, and Peutz-Jeghers syndrome. The goal was to find the genetic causes and link them to specific symptoms. Researchers used clinical exams and genetic testing to better understand how these dis…

This study investigated whether environmental exposures during military service increase the risk of developing myositis, a rare autoimmune disease that attacks muscles. Researchers compared 37 military personnel with and without myositis using questionnaires and blood samples. N…

This study is building an international registry of people with GNE myopathy, an ultra-rare muscle disease that causes progressive weakness and often leads to wheelchair use. Participants will complete online questionnaires about their symptoms, medical history, quality of life, …

This study looked at whether certain natural proteins in saliva are linked to severe tooth decay in young children. Researchers compared 50 Turkish children aged 3-6 with and without severe cavities. They measured levels of antimicrobial peptides in saliva to see if differences e…

This study follows up to 5,000 people with autoinflammatory diseases (like NOMID, CANDLE, and juvenile dermatomyositis) and their healthy relatives. Researchers will collect medical history, blood samples, and imaging over 2-5 day visits to learn how these diseases work and find …

This study looks at how smoking affects proteins linked to blood vessel formation in gum disease. Researchers will measure levels of KLF2, FBXW7, and other markers in fluid from around the teeth and in saliva from adults who are smokers or non-smokers, with healthy gums, gingivit…

This study looks at how a simple monitor called the Pleth Variability Index (PVI) changes during laparoscopic-assisted vaginal hysterectomy. Researchers will track PVI at six key moments when the patient's body position changes, such as tilting the head down or raising the legs. …

This study looks at whether smoking and advanced gum disease (Stage III periodontitis) are linked to changes in three saliva markers: TNF-α, FoxO-1, and SIRT-1, which are involved in inflammation and stress responses. Researchers will compare saliva samples from 80 adults divided…

This observational study looks at how different foot arch heights—flat, high, or normal—affect leg muscle tone, strength, and balance in healthy young adults aged 18 to 25. Participants are grouped by arch type and undergo tests for static and dynamic balance, muscle tone, and st…

This trial compares two different sequences of nickel-titanium (NiTi) archwires used in braces to see which one aligns teeth faster, causes less discomfort, and leads to less root shortening. It involves 60 people aged 12-35 who need full orthodontic treatment for crowding. Parti…

This study looked at how gum tissue heals when taken from two different areas of the palate (roof of the mouth) to treat receding gums. Forty healthy adults aged 20-40 had a gum graft taken either from the front or back of the palate. Using 3D scans, researchers measured volume c…

This study investigates whether proteins from the Hippo signaling pathway—known to control cell growth and bone health—are present at different levels in the gum fluid of people with healthy gums, gingivitis, or periodontitis. Researchers will collect fluid samples from 75 partic…

This study looks at families where one sibling has a rheumatic disease (like rheumatoid arthritis or lupus) and the other does not. Researchers compare their blood, genes, and environmental exposures to find clues about why one got sick. Over 1,000 participants are involved, incl…

This study follows nearly 90,000 farmers and their spouses to track long-term health effects of pesticides, crops, and animals. Participants report new medical conditions, which researchers then confirm through medical records and genetic samples. The goal is to better understand…

This study asks whether pioglitazone, a widely used diabetes medication, might reduce bone density in people with type 2 diabetes. Researchers will compare bone mineral density and bone turnover markers in adults aged 30-55 who take pioglitazone versus those who do not. The goal …

This study looks at whether blood tests called bone turnover markers can quickly show if osteoporosis drugs are working in postmenopausal women. Forty women will receive either bone-strengthening or bone-building medications for six months. The goal is to see if these blood tests…

This trial asks whether two common cleaning methods—mechanical polishing with a paste or applying a 35% hydrogen peroxide gel—change the readings of a laser device (DIAGNOdent) used to spot early tooth decay on the chewing surfaces of back teeth. In each participant, one side of …

This study tested whether educational podcasts and videos created by artificial intelligence could improve knowledge about osteoporosis and digital health literacy. Sixty adults aged 45 and older with osteoporosis or at risk for it received either audio or video content based on …

This study tested whether letting doctors practice on a 3D virtual reality model of a patient's spine before a real injection makes the procedure faster and safer. Thirty adults with difficult-to-treat back pain took part. The main goal was to see if VR training reduced procedure…

This study explores whether a single bout of exercise can protect against muscle damage from a later session—a phenomenon called the repeated bout effect—in people with neuromuscular diseases. Unlike healthy individuals, patients with these conditions may experience muscle damage…

This study looks at whether it is safe and possible to do a special exercise test (MRI combined with a bike workout) in 20 people who already have a specific type of pacemaker. The goal is to see how different pacemaker settings affect the heart's pumping ability during light exe…

This trial asks whether the barbell back squat or the barbell hip thrust is better for building glute muscle and strength. About 39 young, untrained adults will train twice a week for nine weeks with one of the two exercises. Researchers will measure muscle size with MRI and stre…

This study looked at three substances in saliva—Adseverin, 1-alpha defensin, and sRANKL—to see if they differ between people with healthy gums, gingivitis, or periodontitis. Researchers collected saliva from 60 non-smoking, systemically healthy adults and measured these biomarker…

This study looks at how scar tissue (fibrosis) forms in the heart in conditions like aortic stenosis, heart damage from chemotherapy, and carcinoid syndrome. Researchers will use special PET scans to see active scarring early. About 180 adults will take part to help improve detec…

This study looks at how gum disease, from mild gingivitis to more severe periodontitis, changes the activity of certain genes and proteins involved in inflammation and cellular cleanup. Researchers will collect small gum tissue samples from people with healthy gums, gingivitis, o…

This study looks at whether a painful hand condition called De Quervain's tenosynovitis, linked to heavy smartphone use, affects hand grip strength and quality of life in teenagers. Researchers will compare two groups of smartphone-addicted adolescents: those with the condition a…

This observational study looks at whether two proteins found in saliva—Gasdermin E and Granzyme B—are present in different amounts in people with periodontitis (a severe form of gum disease) compared to those with healthy gums. Researchers will collect saliva samples and measure …

This study investigates whether chronic neck pain changes how the neck works in people with temporomandibular disorders (TMD), and whether those neck changes relate to jaw function, mouth opening, and jaw pain. Researchers will compare 67 adults with TMD—some with chronic neck pa…

This study tests whether the way a clear aligner's edge meets the gumline changes the types of bacteria living in the gum pocket. 36 people in the finishing phase of orthodontic treatment wore aligners with two different edge designs at the same time—one covering a bit of gum, th…

This trial investigates whether combining group and individual educational sessions helps patients with chronic inflammatory rheumatism (like rheumatoid arthritis or spondyloarthritis) learn safety skills better than individual sessions alone. Participants are starting their firs…

This study investigates whether stress inside gum cells plays a role in periodontal disease, which causes inflammation and damage to the tissues supporting the teeth. Researchers measured markers of cell stress and inflammation in fluid and tissue samples from 72 non-smoking adul…

This study looks at how the thigh muscles control the movement of the knee cap in people with long-term knee cap pain. Researchers will use MRI scans to compare knee movement in people with pain and healthy volunteers. In a second session, they will temporarily numb a thigh muscl…

This study looks at why gum disease (gingivitis) develops at different rates in different people. Healthy adults aged 18 to 35 will stop brushing and flossing for 3 weeks to allow mild gum inflammation to develop, then resume normal hygiene to recover. Researchers will take clini…

This study looks at people with neurofibromatosis type 1 (NF1) and their families to find out why some have more severe symptoms than others. Researchers will collect medical history, blood samples, and images to study genes and physical traits. The goal is to identify genes that…

This study looks at whether adolescents with scoliosis have weaker breathing muscles, weaker limb muscles, and poorer balance compared to their healthy peers. Researchers will measure these factors in teens aged 10-20 with mild to moderate scoliosis and in a similar group without…

This study investigates whether specific proteins involved in inflammation are present at different levels in people with healthy gums, gingivitis, or periodontitis. Researchers will collect saliva, gum fluid, and gum tissue samples from 75 adults and measure the levels of these …

This study looked at 719 people, including patients with autoimmune connective tissue diseases like myositis, their blood relatives, and healthy volunteers. Researchers collected blood samples and medical histories to find genetic and environmental factors that may trigger these …

This study looks at how lung function, respiratory muscle strength, balance, and quality of life relate in Paralympic athletes. Researchers will measure breathing capacity, muscle strength, and balance in 24 athletes from sports like athletics, swimming, archery, and wheelchair b…

This study looks at how natural variations in the frontal sinus recess—a narrow passage that drains the frontal sinus—might affect endoscopic sinus surgery for people with frontal sinus disorders. Researchers will use CT scans and surgical observation to map these variations in 4…

This study looks at how smoking and gum disease (periodontitis) affect certain proteins and genetic markers in the body. Researchers will compare these markers in smokers and non-smokers with and without gum disease, before and after a standard deep-cleaning treatment. The goal i…

This study explores how weight-loss surgery changes the body's protein needs and whether fast-absorbing milk proteins can help preserve muscle mass and strength. Researchers will measure nitrogen balance and muscle function in 25 adults with severe obesity before and after gastri…

This study looks at whether using an activity tracker with motivational feedback helps people become more active after knee replacement surgery compared to using a tracker without feedback. About 152 adults aged 40-85 scheduled for knee replacement will take part. The goal is to …

This study tested a school program called SocLaLola that uses a comic book to teach children aged 8-11 about pain. The goal was to see if it improves kids' understanding of pain and reduces their fear of moving. Eighty-two students from two primary schools took part. The program …

This study looks back at medical records of people who had an allogeneic stem cell transplant to see whether romiplostim helped their platelets recover faster. Platelets are blood cells that help clotting, and low counts are common after transplant. The researchers will compare p…

This study looked at 324 people with hearing loss and an inner ear problem called enlarged vestibular aqueducts. Researchers collected DNA, hearing tests, and scans to find genes that may cause the condition. The goal was to learn more about why it happens, not to test a treatmen…

This observational study looks at how people's beliefs about pain—whether they see it as psychological or organic—relate to fear of movement, pain catastrophizing, pain knowledge, and disability in individuals with chronic shoulder pain. Researchers will assess 109 adults aged 18…

This study looks at whether gum disease (periodontitis) is linked to higher levels of inflammation in people who have had a heart transplant. Inflammation is known to play a role in the long-term health of a transplanted heart. The researchers measured gum health and took blood s…

This study looks at whether anxiety about climate change is linked to worse sinusitis symptoms and lower quality of life in adults with chronic rhinosinusitis. Researchers will ask about 134 adults to complete questionnaires measuring sinus symptoms, quality of life, and climate …

This study looks back at medical records of people with two rare genetic conditions—ENPP1 deficiency and the early-onset form of ABCC6 deficiency—to map how these diseases progress over time. By collecting information on symptoms, imaging, and growth, researchers hope to better u…

This study follows boys with Duchenne muscular dystrophy who have small mutations in their genes, a group that is less understood than others. Over one year, researchers will use muscle MRI, genetic tests, and motor and respiratory assessments to see how the disease progresses. T…

This observational study will look at 138 adults with hemophilia and joint damage to understand how central pain mechanisms and psychological factors like anxiety affect pain interference in daily activities. Researchers will measure pain intensity, sleep quality, and pain self-e…

This study looks at how a common jaw joint problem (TMJ disc displacement) might be connected to changes in the neck bones. Researchers will use X-rays and MRIs to measure the shape and posture of the upper neck vertebrae in 115 people with TMJ issues. The goal is to better under…

This study examined 318 adults to see if coffee drinking habits are linked to gum health. Participants were grouped by gum condition (healthy, gingivitis, or periodontitis) and asked about their coffee intake. Researchers measured plaque, bleeding, and gum pocket depth to find an…

This study tests whether a smartphone-based digital assessment can measure rheumatoid arthritis activity as well as a standard doctor-performed exam. Adults with rheumatoid arthritis will complete a digital questionnaire, record guided videos of their joint movements, and then ha…

This observational study looks at how people with spinal cord injuries maintain balance while performing a stationary wheelchair wheelie. Participants will be asked to hold a wheelie for at least 20 seconds while sensors track their body movements and balance. The goal is to unde…

This study tests whether ultrasound can map blood vessels in the lower jaw before gum recession surgery. Four adults with gum recession will receive a coronally advanced flap procedure, and researchers will compare ultrasound images taken before surgery with what they see during …

This trial tests whether taking cordyceps supplements alongside fartlek training — a type of speed-play workout — can reduce muscle damage, inflammation, and oxidative stress in competitive soccer players aged 18–20. Over four weeks, researchers measure blood markers of muscle in…

This study uses ultrasound to measure the hips of healthy newborns between 32 and 46 weeks gestational age. The goal is to create a growth chart showing normal hip measurements, which could help doctors better diagnose developmental dysplasia of the hip (DDH) in infants. Research…

This project creates a central repository of medical records, genetic test results, and patient-reported information from people with Duchenne or Becker muscular dystrophy, as well as carriers. Anyone aged 4 weeks or older with a confirmed diagnosis can join. The goal is to provi…

Osteoporosis is a common complication after spinal cord injury, raising the risk of broken bones. This study surveys 94 adults with chronic traumatic spinal cord injury to measure their awareness of osteoporosis and identify factors — such as education level or healthcare visits …

This study uses ultrasound to measure diaphragm movement and breathing in 15 adults receiving a stellate ganglion block — a nerve injection for certain pain conditions. The goal is to see how often the block temporarily paralyzes one side of the diaphragm. Researchers also check …

This study investigates whether the severity of periodontitis (a serious gum infection) differs between Egyptian men and women. Researchers will examine 380 participants aged 20 to 40, all with periodontitis, using a clinical exam and a detailed questionnaire about oral hygiene, …

This observational study investigates whether levels of certain enzymes (ACE and ACE2) in saliva and blood are linked to the severity of gum disease in adults with cardiovascular disease. Researchers will compare these enzyme levels across different stages of gum disease—from gin…

This study looks back at 21 children and teens diagnosed with a rare type of lymphoma that starts in the bone. Researchers are collecting medical records to describe how the disease presents, how it was treated, and how well patients did over time. The goal is to learn more about…

This study compares two popular ways to straighten teeth in adults with mild-to-moderate crowding: clear aligners and traditional fixed braces. The main question is whether the two methods differ in how they affect the bone that surrounds the teeth. Using 3D X-ray scans and digit…

This study investigates whether systemic ozone therapy, used for conditions like chronic pain and osteoarthritis, damages the corneal endothelium—the eye's inner layer that keeps the cornea clear. Researchers will compare 48 patients receiving ozone therapy with 48 healthy matche…

This study aims to discover new genes and mutations that cause isolated forms of amelogenesis imperfecta and dentinogenesis imperfecta—inherited conditions that affect tooth enamel and dentin. Researchers are using whole exome sequencing on participants who have these tooth disor…

This study tracks how often swallowing difficulties (dysphagia) and voice changes (dysphonia) happen after anterior cervical spine surgery — a common procedure to treat a narrow spinal canal. Researchers will follow 36 patients for one year after surgery, using questionnaires and…

This study examines nanofat—a processed form of a person's own fat—to see if it could be used as a cell therapy for rhizarthrosis, a common and painful form of thumb osteoarthritis. Researchers will collect fat samples from healthy volunteers and analyze the cells and sterility i…

This study looks at how young people with conditions like cerebral palsy, spina bifida, and spinal cord injury move from pediatric to adult medical care. Researchers will review medical records from the past 10 years and interview patients who have already made the switch. The go…

This study explores whether electrically stimulating the leg muscles of people with spinal cord injury can improve cognitive function. Participants will receive 12 weeks of neuromuscular electrical stimulation (NMES) to their quadriceps, three times a week. Researchers will measu…

This study looks at how working from home affects posture, neck and back pain, and internet use. Researchers will measure spine angles and muscle structure in adults who work remotely, and assess their internet addiction levels. The goal is to understand if increased screen time …

This study investigates how gum disease—from mild gingivitis to severe periodontitis—affects specific proteins inside gum tissue cells that help control cellular cleanup and communication. Researchers will collect small gum samples from people with healthy gums, gingivitis, or pe…

This study looks at whether certain genetic variations (in COMT, MAOA, and SLC6A4) influence how well a standard dental numbing injection works for people with a painful tooth condition called irreversible pulpitis. Participants received a numbing shot and had their pain levels m…

This study looks at two ways to examine the uterine cavity after women have had hysteroscopic surgery for conditions like polyps, fibroids, or a uterine septum. One method is a non-invasive 3D ultrasound; the other is an office hysteroscopy, which involves inserting a small camer…

This study follows about 25 adolescents aged 12–17 with X-Linked Hypophosphatemia (XLH) who are being treated with burosumab and are nearing the end of their skeletal growth. Researchers will track symptoms, activity levels, and overall burden through surveys and interviews over …

This study looks at how mepolizumab (Nucala), a treatment for severe eosinophilic asthma, impacts emotions and mental well-being in patients and their partners. Researchers will track changes in feelings like anxiety, depression, and stress using questionnaires and interviews. Th…

This study compares two methods of preparing the bone for dental implants: high-speed drilling with cooling water versus low-speed drilling without water. Fifty healthy adults needing implants will be randomly assigned to one of the two techniques. Researchers will measure bone l…

This study looks at people with musculoskeletal conditions (like back or joint problems) who take part in a work-specific rehabilitation program called RehaJET. The goal is to see whether a 3-week or a 4-week program leads to better work ability and job outcomes. Researchers will…

This study measures levels of a substance called adropin in the gum fluid and blood of people with periodontitis (severe gum disease) and compares them to healthy gums. Researchers want to see if adropin changes after standard non-surgical gum treatment, and how it relates to a k…

This trial tests different doses of a fluorescent dye called IC-Green in people having arthroscopic rotator cuff repair. The dye binds to blood proteins and makes blood vessels visible under a special camera. The goal is to find the best dose for seeing blood flow in the torn ten…

This registry study collects detailed information from 45,000 adults undergoing fast-track hip or knee replacement at eight Danish hospitals. Researchers track patient health before surgery and complications afterward, including hospital stays, readmissions, and deaths within 90 …

This observational study investigates how different levels of gum health influence asprosin (a hormone) and total oxidant/antioxidant levels in people with type 2 diabetes. Researchers will collect fluid from around the gums and blood samples from 67 participants to compare these…

This study tests three different force levels (2 kg, 5 kg, and 11 kg) of the 'crossed hands' myofascial release technique on healthy adults. The goal is to see how each force affects muscle stiffness, thickness, pain sensitivity, and lower back and hip mobility. By finding the mo…

This study investigates whether people with late-onset Pompe disease have a higher risk of severe blood vessel problems in the brain and aorta. Researchers will collect medical and genetic data from adults with Pompe disease and from those who have had a brain aneurysm or bleedin…

This study looks at how well people with temporomandibular disorder (TMD) can sense the position of their neck, how sensitive their jaw muscles are to pressure, and the angle of their head posture. Researchers will compare 30 adults — half with TMD and half healthy — to see if th…

This study looks at people with chronic constipation to see if a specific muscle problem called puborectalis syndrome can be better identified using three different tests: defecography, high-resolution anorectal manometry, and pelvic floor ultrasound. Researchers will compare res…

This study follows children aged 2 to 18 with confirmed ENPP1 deficiency or early-onset ABCC6 deficiency to understand how these rare diseases progress. Researchers will measure blood markers, check for calcification in arteries and organs, and track bone health and movement over…

This observational study looks at how anthracycline chemotherapy affects inflammation, oxidative stress, and heart function in adult women who had breast cancer. Researchers measure blood markers and use echocardiograms to assess heart changes about 10 years after treatment. The …