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Battle of the smile fixers: which treatment brightens Fluorosis-Stained teeth best?
NCT ID NCT07707349
First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time
Summary
This trial compares two minimally invasive treatments—Antivet and Opalustre—for improving the appearance of mild enamel fluorosis, a condition that causes tooth discoloration. Adults aged 20 to 35 with mild fluorosis on their front teeth are randomly assigned to receive one of the two treatments. Tooth color is measured before and after treatment using a special device to see which option works better.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Antivet (microabrasion) or Opalustre (enamel microabrasion)
- What this could lead to
- If one treatment proves more effective, it could offer a better option for improving the appearance of discolored teeth due to fluorosis.
- What could go wrong
- This is a small trial with only 59 participants, and results may not apply to everyone. Both treatments are minimally invasive, but individual results vary.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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59 people
The number who actually took part.
- Started
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May 2026
- Finished
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Jul 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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20 to 35 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Patients aged from 20-35 years old. 2. Patients free from any systematic diseases. 3. Patients agreed to the informed consent and are compliant to the follow-up periods. 4. Teenagers and young adult patients refrained from tobacco products throughout the current study period. 5. Patients with hypominerlized maxillary and mandibular ante- rior teeth (incisors and canines) were included. 6. Teeth with Degree 1 (mild) according to the Wetzel and Reckel scale. Exclusion criteria 1. Patients with special health care needs or any systemic disease that may delay normal healing. 2. Patients having bad oral hygiene. 3. Patients who could not be committed to the follow-up period. 4. Patients suffering from untreated, periodontal diseases 5. Participants with caries lesions or defective restorations in the anterior teeth. 6. Sensitive and fractured teeth. 7. Participants who had a history of dental bleaching. 8. Patients participating in other dental studies. 9. Patients suffering from hypoplasia, amelogenesis imperfecta, dentinogenesis imperfecta, tetracycline stains, fluorosis, or badly broken and missing teeth due to MIH.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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October University for Modern Sciences and Arts
Giza, Sixth of October, 12566, Egypt
More trials for these conditions
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