Can botox beat ibuprofen for jaw pain from teeth grinding?
NCT ID NCT07732751
First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time
Summary
This trial compares Botox injections with ibuprofen pills to see which better eases jaw muscle pain and improves quality of life in people with sleep bruxism (teeth grinding). Forty adults with jaw pain are randomly assigned to receive either Botox injections into the masseter and temporalis muscles or a one-week course of oral ibuprofen. Researchers track pain levels, oral health-related quality of life, muscle tenderness, and jaw function over 20 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- botulinum toxin type A (Botox) injections into the jaw muscles
- What this could lead to
- If Botox proves better than ibuprofen, it could offer a longer-lasting treatment option for chronic jaw pain from teeth grinding.
- What could go wrong
- This is a small, early-phase trial with only 40 participants. Botox injections carry risks like temporary muscle weakness or bruising, and the results may not apply to everyone with bruxism.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for BRUXISM are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
New Cyprus Health and Social Sciences University
Güzelyurt (Morphou), Northern Cyprus, 99750, Cyprus
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Do wind instruments cause more jaw pain? survey targets amateur musicians
- Hands-On therapy plus pilates may unlock relief for teeth grinders
- Could spit reveal the stress behind teeth grinding?
- Ultrasound reveals how jaw pain treatments change muscles
- Face shape may predict botox success for teeth grinders
- Can a few therapy sessions ease jaw pain and improve sleep?