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Could spit reveal the stress behind teeth grinding?

NCT ID NCT07702019

Knowledge-focused Sponsor: Giresun University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Jul 14, 2026 · Last updated Jul 15, 2026 · Updated 1 time

Summary

This observational study looks at whether people with bruxism (teeth grinding or clenching) have different levels of certain substances in their saliva, such as cortisol and immune markers, compared to healthy individuals. It also examines if these biological markers are linked to how much stress a person feels. Participants provide a saliva sample and fill out a stress questionnaire, helping researchers understand the connection between stress and bruxism.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

56 people

The number who actually took part.

Started

May 2025

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consisted of adults with clinically diagnosed bruxism and age- and sex-matched healthy control participants recruited from the Faculty of Dentistry. All participants underwent clinical examination, completed the Perceived Stress Scale (PSS-14), and provided unstimulated saliva samples for biomarker analysis.

Ages

25 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 25 to 50 years. * Systemically healthy individuals. * Presence of no more than four-unit fixed partial dentures. * Absence of clinical signs of oral inflammation. * Good oral hygiene. * Individuals diagnosed with bruxism according to the study diagnostic criteria (bruxism group) or healthy volunteers without signs or symptoms of bruxism (control group). * Ability and willingness to provide written informed consent. Exclusion Criteria: * Use of medications that may affect the nervous system or salivary gland function (e.g., benzodiazepines, antidepressants). * Psychiatric disorders. * Epilepsy. * Diabetes mellitus or other pancreatic diseases. * Current corticosteroid therapy. * Cushing syndrome or Addison disease. * Pregnancy. * Current smoking. * Alcohol or substance abuse. * History of facial trauma. * Rheumatic muscle or joint disorders. * Degenerative joint disease. * Migraine. * Use of medications affecting sleep or motor activity. * Recent history of occlusal splint therapy. * Salivary gland disorders, including Sjögren syndrome or autoimmune sialadenitis.

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Conditions

The condition(s) this trial relates to.

bruxism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bruxism

Contacts and locations

Locations

  • Giresun University Faculty of Dentistry

    Giresun, 28200, Turkey (Türkiye)

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