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Blood-Derived injection may heal stubborn knee tendon pain — trial puts it to the test

NCT ID NCT01843504

Disease control Sponsor: University of Wisconsin, Madison Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This trial investigates whether a single injection of platelet-rich plasma (PRP), made from a person's own blood, can reduce pain and improve function in chronic patellar tendinopathy (knee tendon pain). The study includes 29 adults aged 18–65 who have had tendon pain for over three months and have not improved with physical therapy or other common treatments. Researchers will use ultrasound imaging to track tendon changes over 32 weeks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a single injection of platelet-rich plasma (PRP) made from the participant's own blood
What this could lead to
If effective, PRP injections could offer a non-surgical treatment option for chronic patellar tendinopathy, reducing pain and improving knee function.
What could go wrong
This is a small Phase 2 trial with only 29 participants, so results may not apply broadly. PRP injections can cause temporary pain or swelling at the injection site.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

29 people

The number who actually took part.

Started

Feb 2014

Finished

Feb 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. age18-65 2. chronic (\>3months) patellar tendon pain; 3. clinical exam findings consistent with PT; 4. self-reported failure of supervised physical therapy; 5. self-reported failure of at least 2 of the most common treatments (NSAIDs, relative rest, ice, bracing) for patellar tendinopathy. Exclusion Criteria: 1. inability to comply with follow-up requirements of study, 2. history of bleeding disorders, low-platelet counts, other hematologic conditions; 3. knee pain due to another possible etiology(e.g., degenerative joint disease); 4. current or recent use of anticoagulation or immunosuppressive therapy; 5. known allergy to acetaminophen or Lidocaine; 6. self-reported pregnancy; 7. worker's compensation injury; 8. pending litigation; 9. concurrent opioid use for pain

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Conditions

The condition(s) this trial relates to.

chronic prostatitis disease of the tendon Patella Fracture patellar tendinitis tendinosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic patellar tendinopathy Chronic PT

Contacts and locations

Locations

  • UW Sports Medicine Clinic at Research Park

    Madison, Wisconsin, 53711, United States

  • Wisconsin Institute of Medical Research

    Madison, Wisconsin, 53705, United States

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