Gentler gum surgery could repair deep defects without cutting the gums

NCT ID NCT04444063

First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time

Summary

This study compares a new, less invasive gum surgery (NIPSA) alone versus the same surgery plus a bone graft and platelet-rich fibrin to repair deep bone defects caused by advanced periodontitis. The trial enrolls adults with stage III periodontitis who have at least one deep gum pocket. Researchers will measure how much the surgery improves tooth attachment, reduces pocket depth, and fills in bone defects over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
allograft plus platelet-rich fibrin
What this could lead to
If successful, this approach could offer a less invasive surgical option to repair deep gum defects and improve tooth support in advanced periodontitis.
What could go wrong
This is a small, early-stage trial with only 20 participants, so results may not apply to everyone. The added graft may not improve outcomes over surgery alone, and any surgery carries risks like infection or gum recession.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Faculty of Dentistry -Cairo Unversity

    Cairo, Egypt

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