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Gentler gum surgery could repair deep defects without cutting the gums

NCT ID NCT04444063

Disease control Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time

Summary

This study compares a new, less invasive gum surgery (NIPSA) alone versus the same surgery plus a bone graft and platelet-rich fibrin to repair deep bone defects caused by advanced periodontitis. The trial enrolls adults with stage III periodontitis who have at least one deep gum pocket. Researchers will measure how much the surgery improves tooth attachment, reduces pocket depth, and fills in bone defects over time.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
allograft plus platelet-rich fibrin
What this could lead to
If successful, this approach could offer a less invasive surgical option to repair deep gum defects and improve tooth support in advanced periodontitis.
What could go wrong
This is a small, early-stage trial with only 20 participants, so results may not apply to everyone. The added graft may not improve outcomes over surgery alone, and any surgery carries risks like infection or gum recession.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Mar 2021

Finished

Oct 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with Stage III periodontitis patient having at least one tooth with two wall or combined two to three walled intraosseous defect more than or equal 3 mm deep (assessed by trans-gingival probing, radiographic examination) with clinical attachment level (CAL) more than or equal 5mm and pocket depth (PD) more than or equal 6 mm. * Defect not extending to a root furcation area. * Vital teeth * No history of intake of antibiotics or other medications affecting the periodontium in the previous 6 months. * No surgical periodontal therapy carried out in the past 6 months. * Able to sign an informed consent form. * Patients who are cooperative, motivated, and hygiene conscious. * Able to come for the follow up appointment's needed. Exclusion Criteria: * Any systemic disease that contra-indicates periodontal surgery or may affect healing. * Smokers * Pregnant females * Drug abusers

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Conditions

The condition(s) this trial relates to.

chronic periodontitis periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Intrabony periodontal defect Periodontitis chronic generalized severe

Contacts and locations

Locations

  • Faculty of Dentistry -Cairo Unversity

    Cairo, Egypt

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