Can new biomaterials regrow bone in advanced gum disease?
NCT ID NCT07738705
First seen Jul 31, 2026 · Last updated Jul 31, 2026
Summary
This trial tests different combinations of biomaterials used during gum surgery to treat class II furcation defects—areas where bone loss has occurred between the roots of molars. The goal is to see which combination best encourages bone regrowth and improves gum thickness. Adults with advanced periodontitis and at least one affected molar may participate. The study measures bone gain and gum changes using 3D imaging over six months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Surgical procedure using different biomaterial combinations (NovaBone, allograft, microderm or collagen membranes)
- What this could lead to
- If successful, this could identify a better biomaterial combination to regenerate bone and gum tissue in people with advanced gum disease, potentially improving tooth retention.
- What could go wrong
- This is a small, early-stage trial with 48 participants, so results may not apply broadly. Surgery carries risks like infection or poor healing, and the outcome depends on individual response.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
LECOM School of Dental Medicine
Bradenton, Florida, 34211, United States
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Other studies related to the condition(s) this trial covers.
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