Weight loss drug could ease heart failure in obese patients

NCT ID NCT05371496

ENROLLING_BY_INVITATION Symptom relief Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Mar 17, 2026 · Last updated May 18, 2026 · Updated 8 times

Summary

This study tests whether aggressive weight loss using semaglutide can improve symptoms in people with obesity-related heart failure with preserved ejection fraction (HFpEF). About 81 participants will receive either semaglutide or a placebo, and researchers will measure heart pressure during exercise. The goal is to see if losing weight eases the strain on the heart.

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Contacts and locations

Locations

  • Mayo Clinic in Rochester

    Rochester, Minnesota, 55905, United States

Conditions

Explore the condition pages connected to this study.