Can a simple mouthwash silence sensitive teeth?
NCT ID NCT07741032
First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time
Summary
This trial tests whether two experimental mouthwashes can relieve dentinal hypersensitivity—sharp pain from hot, cold, or air on teeth. About 118 adults with sensitive teeth will use one of the mouthwashes or a placebo, either once or twice daily, for up to 8 weeks. Researchers will measure changes in sensitivity to air and touch, as well as how the condition affects quality of life.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Two experimental mouthwashes: one with 3% potassium nitrate (KNO3) and one with 2% hydroxypropyl cellulose (HPC), both with fluoride, compared to a placebo mouthwash.
- What this could lead to
- If successful, these mouthwashes could offer a simple, at-home way to reduce tooth sensitivity and improve comfort when eating, drinking, or brushing.
- What could go wrong
- This is an early proof-of-concept study, so results may not hold up in larger trials. The mouthwashes might not outperform the placebo, and some people may not respond to treatment.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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proDERM
Harburg, Free and Hanseatic City of Hamburg, Germany
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