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Gum disease repair: could a hyaluronic acid gel rival the gold standard?

NCT ID NCT04274244

Completed Disease control Sponsor: University of Valencia Source: ClinicalTrials.gov ↗

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This study tests whether a gel made from cross-linked hyaluronic acid (Hyadent BG®) can help regrow bone and gum tissue destroyed by chronic gum disease, comparing it to a standard treatment called Emdogain®. About 53 adults with moderate periodontitis will receive one of the two gels during a minimally invasive surgical procedure. Researchers will measure changes in gum attachment and bone levels over time to see which approach works better.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
cross-linked hyaluronic acid 1.8% gel (Hyadent BG®)
What this could lead to
If effective, this gel could offer a simpler, less costly option to regenerate bone and gum tissue lost to periodontitis.
What could go wrong
This is a small, early-phase comparison study. Results may not apply to all patients, and the gel may not work as well as the standard treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alveolar Bone Loss chronic periodontitis periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC PERIODONTITIS PERIODONTAL BONE LOSS

Contacts and locations

Locations

  • University of Valencia

    Valencia, Valencia, 46010, Spain

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