Spinal cord stimulation may help restore movement after paralysis

NCT ID NCT04736849

Completed Disease control Sponsor: Peter J. Grahn, Ph.D. Source: ClinicalTrials.gov ↗

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This pilot study tests whether electrical stimulation of the spinal cord can improve motor function and reduce spasticity in people with spinal cord injury. Participants receive epidural and dorsal root stimulation during 10 rehabilitation sessions. The study measures changes in muscle activity, foot pressure, and trunk balance.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: electrical stimulation of the spinal cord via implanted leads
What this could lead to: If successful, this approach could help restore some movement and reduce muscle stiffness in people with spinal cord injury.
What could go wrong: This is a small early-stage pilot study with only 22 participants, so results may not apply to everyone. The stimulation involves surgery and carries risks like infection or lead movement.

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Conditions

The condition(s) this trial relates to.

palsy paraplegia quadriplegia spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PARALYSIS PARAPLEGIA SPINAL CORD INJURIES TETRAPLEGIA

Contacts and locations

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Locations

Mayo Clinic

Rochester, Minnesota, 55905, United States

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