Light-Activated therapy may boost gum disease treatment, especially for smokers
NCT ID NCT07697963
First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time
Summary
This study tests whether adding photodynamic therapy (PDT) to standard deep cleaning (scaling and root planing) improves gum disease treatment more than cleaning alone. The trial includes both smokers and non-smokers to see if the extra treatment helps smokers, who often have worse outcomes. Participants receive both treatments in different parts of their mouth, and the main goal is to measure how much gum pocket depth decreases.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Photodynamic therapy (PDT) plus scaling and root planing
- What this could lead to
- If PDT proves more effective than standard cleaning alone, it could offer a better way to control gum disease, especially for smokers who often respond poorly to traditional treatment.
- What could go wrong
- This is a very early-phase study with only 120 participants, so results may not apply broadly. PDT is an add-on treatment and is not expected to cure gum disease.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Early phase 1
The earliest testing in people: a first look at safety, in a very small group.
- Participants
-
120 people
The number who actually took part.
- Started
-
Jan 2015
- Finished
-
Dec 2015
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 65 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * at least two teeth with periodontal pockets up to 4 mm Exclusion Criteria: * less than two teeth with periodontal pockets
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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Other studies related to the condition(s) this trial covers.
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