Cure My Disease

Don't miss your cure!

 Log in / Sign up

Could a simple liquid stop cavities without drilling?

NCT ID NCT06861725

Disease control Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time

Summary

This trial tests whether a liquid called silver diamine fluoride (SDF) can stop early cavities in molars as effectively as the standard treatment, a plastic coating called fissure sealant. Adults aged 20 to 45 with early, non-cavitated cavities will be randomly assigned to receive either SDF or sealant. Researchers will check the teeth at 1, 3, 6, and 12 months to see if the cavity has stopped growing or if new cavities form.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
silver diamine fluoride (SDF) and fissure sealant
What this could lead to
If SDF works as well as or better than sealants, it could offer a simpler, less invasive way to stop early cavities without drilling.
What could go wrong
This is a small trial with 76 participants, and SDF stains cavities dark, which may be cosmetically unappealing. Results may not apply to deeper or more advanced cavities.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

76 people

The number who actually took part.

Started

Apr 2025

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patient consulting in the outpatient clinic. 2. Patients with enamel caries in molars permanent teeth, according to ICDAS 1 and 2. 3. Provide informed consent. 4. Co-operative patients approving to participate in the trial. 5. Patient age (20-45 years old). Exclusion Criteria: 1. Tooth mobility. 2. Signs of pulpal infection. 3. Severe medical conditions that would not allow management in the clinic. 4. Hereditary developmental defects, such as amelogenesis imperfecta or dentinogenesis imperfecta. 5. Known allergies or sensitivities to dental materials, including SDF and fissure sealant. 6. Inability to return for recall visits. 7. Patients with bad oral hygiene 8. Refuse to participate in the study.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Caries arrested are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

dental caries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Caries arrested Dental caries Fissure sealant Silver diamine fluoride

Contacts and locations

Locations

  • Cairo university - Dentistry Facility

    Cairo, Cairo Guv, 12613, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.