Could a simple liquid stop cavities without drilling?

NCT ID NCT06861725

Completed Disease control Sponsor: Cairo University Source: ClinicalTrials.gov ↗

First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time

Summary

This trial tests whether a liquid called silver diamine fluoride (SDF) can stop early cavities in molars as effectively as the standard treatment, a plastic coating called fissure sealant. Adults aged 20 to 45 with early, non-cavitated cavities will be randomly assigned to receive either SDF or sealant. Researchers will check the teeth at 1, 3, 6, and 12 months to see if the cavity has stopped growing or if new cavities form.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: silver diamine fluoride (SDF) and fissure sealant
What this could lead to: If SDF works as well as or better than sealants, it could offer a simpler, less invasive way to stop early cavities without drilling.
What could go wrong: This is a small trial with 76 participants, and SDF stains cavities dark, which may be cosmetically unappealing. Results may not apply to deeper or more advanced cavities.

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Conditions

The condition(s) this trial relates to.

dental caries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARIES ARRESTED DENTAL CARIES FISSURE SEALANT SILVER DIAMINE FLUORIDE

Contacts and locations

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Locations

Cairo university - Dentistry Facility

Cairo, Cairo Guv, 12613, Egypt

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