Gum disease gel: could spermidine make deep cleaning more effective?
NCT ID NCT06792916
First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time
Summary
This study tests whether adding a spermidine-based gel to standard deep-cleaning (MINST) improves gum pocket reduction in adults with periodontitis. Participants receive either the gel plus cleaning or cleaning alone, and gum health is tracked for 12 months. The goal is to see if the gel helps gums heal better and reduces bleeding.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a spermidine-based gel applied locally to the gums
- What this could lead to
- If it works, this could offer a simple, non-surgical way to improve gum healing and reduce pocket depth in people with periodontitis.
- What could go wrong
- This is a very small early-phase trial with only 13 participants, so results may not apply widely. The gel may not provide additional benefit over standard care alone.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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AOU Federico II
Naples, Italy, 80013, Italy